<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10081

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTITTTAPSPSSAEQWRLFLGQCLKHRIDANEFKNLSTLLAARCQVAEPVLVDVLCDVRAVGAAAGVKWDPLVPVYIDCLCKTERVRISSVLGGLLKRSSILPQSQPQSQSSDESEKSKQQKKNGYTLMTDIRVIQDVMLAVSTGNSTPRTAAEAMDIFSAAVDWIRTVVAWHQQHQQTGGLMGSPDVVSLFESLGILLAALSGTPKGLDVLSSDNEGLKIKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFNLYGEPASKSLDMTMMDGMNVNALQFEASVMDGPVINSRAGLYVYINSMLVGRPLIDDNMLLSYLVNRYGGHYKVLIEEMITASFDALSNAMYRNESNRTMFIFRSFLVNKLPAFFATMLAASMVSIPMELCISNALGRLDPNTFPSFSQMFSMQGNTVLSDVRQEFLFACASHRLIPESSIERLLGENPMQAVPVGYVKDDLVSQIYANPERAEQLINDIESTEGNANAIVGAITEVIHQLCNQKESMTLKNICNSLSRRPQALDVILLFRSTKQILQPLCTLLDNWHWDGDQGENQPVYDEFGSILLLILNFKYRYDLKPYELGISSDDSFVLKLLDRGSCSQKLEDLTEKQNKDLGAWIGALFIAEVISEETMSNCSPQEFYLLVTTLFSQSLGACEAGKLEFETLKGGFEYLLEPFLLPSLVVALGWLGNRIWESENEPTIALKTLHSLVSPTSISGEAQAIHQTVLSMTARTLEEQLKDVRARHPSRTDIKPILDALEPHLSFQRTGSCHRTELESWTHSGNGGAGGLLGSIRNTFQSLVLWSTNPEISMAPPSYTHRQVVAGVRMLGASRVLRALEEELKLQTEAGSGDLALDVAAMIVSAPMLESFTADQMHYHPPDNKDQSQQSKQQQAATNLRIPVLTLRDALSIRHQDVPRVSEKDPLRAEMIVRLYRRVNAVTAPTAQVPSLDVSNILGNMSVTDQSAQQQAQSQSQTQQQSQQQQQAQQQAQSQEQQQQNQMDLDANAGDGDFSHMLDTAAAAAGDGGGGMDGMGMGTGLDTSIDDVLNAADIAAVGNPEFLDLDMEGMF
Length1064
PositionTail
OrganismAspergillus cristatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.153
Instability index49.34
Isoelectric point4.91
Molecular weight116891.58
Publications
PubMed=27267057

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10081
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.95|      15|      15|     962|     976|       1
---------------------------------------------------------------------------
  872-  885 (22.67/ 8.26)	YHPPDNKDQS.QQSK
  962-  976 (30.21/13.03)	QQQAQSQSQTQQQSQ
  982-  995 (27.07/11.05)	QQQAQSQEQ.QQQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.70|      15|      29|     288|     302|       2
---------------------------------------------------------------------------
  288-  302 (26.89/15.71)	INSRAGLY.VYINSML
  318-  333 (23.81/13.20)	VNRYGGHYkVLIEEMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.30|      19|      22|     182|     203|       3
---------------------------------------------------------------------------
  184-  202 (33.24/20.76)	GSP...DVVSL.FESLGILLA.AL
  204-  227 (20.07/ 7.06)	GTPkglDVLSSdNEGLKIKLGqAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.96|      14|      20|    1000|    1013|       4
---------------------------------------------------------------------------
 1000- 1013 (28.62/17.15)	ANAGD..GDFSHM.....LDT
 1016- 1036 (17.34/ 7.52)	AAAGDggGGMDGMgmgtgLDT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10081 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PTAQVPSLDVSNILGNMSVTDQSAQQQAQSQSQTQQQSQQQQQAQQQAQSQEQQQQNQMDLDANAGDGDFSHMLDTAAAAAGDGGGGMDGMGMGTGLDTSIDDVLNAADIAAVGNPEFLDLDMEGM
938
1063










Molecular Recognition Features






MoRF SequenceStartStop




NANANA