<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10080

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMDHGINVDDLFGESGSLELGLSPTAPKGLAQRLDEMRLLGCCQKIAWSRLGCIAYISRDGLTVNVRYLHCQPSDGRWCLSEDTPLFPVTEAHGSHPLVHICWNESGSELAVVDSSGRVSIYSISIALNSIAGQRQAAFDPDDEINQVVGMTWLNTQRSVHAFLQAAKVNGRWAYSPFRRRPIGPFHPANKAALVCVTRSGLIKLLYQNPDSRWAEISAELKNTSYSDRLLTHASLVATQAGIIVTTHSVCQKICVYRVHVSWNPPQWDPSTPKQSNLFPVPSFRFAHGNVETPSGIWNTYRNTGENEEAPSSTNSIYALMHLEIIPGAVDNPAGSTANPWILAVYSNPLAATPDHTGQNGSASIIVRWQLEAASQNLHPKFDEVVSKKNHNAQVKPKMELCRLEDIHFDKYVISVDQAEYGTVLAITYDDSSITFYDPKTMAVFNGTDDNSTVTCLTQAGFHSPPEVSGLQISFSPSACAAVMLDSEGQTQLRLMEHSYGAENSLFDESKFSAAIAALTLAFCRGCGSDINTDDILMLVMRQLSSEAQTAFLNEVYRALPINCNFTVDQDKLMNHPYIPRCLSLQAALGFRDRYKPRIFTSAVPWAILHLRHGAVLFAYFFQYIKGIQTDPHDSGVLRMVLGNTRWVLDFSQYILNEVFDLADEFESVLSDQEAFTQKLKTTTSLPLIILLSSMSRTFLRFICRGLRGVHSGYNPSAANLVGDSRIYYSETCHLLDTSPVRIDVYEKFLAGVDSAVRHAYHGAGFGDTERPGPEKELLVNARIPPVLMNAVSAIFRSVVPAVRGEVDRLTIYLGDYTWLGVGDDKRTEVYRRTRDVDILKKIPLRAVVADIGSGANNTSTATSTATNDNNKTGAGQRIRRCIRCCEVSSDTHPPRSLPAFQMIARLGLLRSCICGGMWALEARSPAGQLDGSPAPGSGLQTELRTPGLIQGS
Length956
PositionTail
OrganismAspergillus cristatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.143
Instability index37.64
Isoelectric point6.26
Molecular weight105229.23
Publications
PubMed=27267057

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10080
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     299.22|      94|     206|     411|     513|       1
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  411-  513 (148.76/118.98)	HFDKYV..ISVDQAEYGtVLAITYDDSS..ITFYDPKTMAVFNGTDDNSTVTcltqagfhSPPEVSGLQISFSPSACAAVMLDSEGQTQLRLMEHSYGAENSLFDES
  623-  720 (150.46/98.89)	YFFQYIkgIQTDPHDSG.VLRMVLGNTRwvLDFSQYILNEVFDLADEFESVL........SDQEAFTQKLKTTTSLPLIILLSSMSRTFLRFICRGLRGVHSGYNPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     228.56|      64|     206|      46|     136|       2
---------------------------------------------------------------------------
   54-  120 (114.28/77.02)	LGCIAYISRDGLtvnVRYLHCQPSDGRWCLSEDTPL..FPVTE...AHGSHPLVHICWN...ESGSELAVVDSSG
  166-  204 (41.92/33.23)	.................FLQAAKVNGRWAYS...PFrrRPIGP...FHPANKAALVCVT...RSG..........
  278-  318 (34.55/ 7.90)	................................QSNL..FPVPSfrfAHGNVETPSGIWNtyrNTGENEEAPSSTN
  901-  929 (37.82/ 8.19)	LPAFQMIARLGL...LRSCIC...GGMWALEARSP........................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.23|      36|     148|     581|     618|       3
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  581-  618 (62.46/49.89)	YIPRCLSLQAALGFRDRYKPriFTSAVPWAILHLRHGA
  732-  767 (64.78/45.02)	YSETCHLLDTSPVRIDVYEK..FLAGVDSAVRHAYHGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.23|      53|     517|     326|     383|       4
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  326-  383 (86.09/69.27)	LEIIP.GAVDNPAGSTANPWILAVYSnplaATPDHtGQNGSASIIVR.WQLEAASQNLHP
  843-  897 (84.14/53.71)	LKKIPlRAVVADIGSGANNTSTATST....ATNDN.NKTGAGQRIRRcIRCCEVSSDTHP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10080 with Med16 domain of Kingdom Fungi
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