<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10076

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPLSSAGAQPRGQHPLRAVNTASGQPNTFQAFAQSEANLPTPVSQAQFRQQPTVIDLTGGEDAQEREPPAKRPRLDIPTGTSSRTASPVPGVSGVGGGDLRSAPGGPTTPRPPSTTSWRGRPVWSFQSLVSETPGVGDVNGDNAAALAQGGKPASPPPLPTPPWRFAQRSSSSRSEDNSPVKAVQTTPYRIETPAAAPALIGEKVADFSPWTGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFASAFEKRQGHNTVATSSTFKPPPRVTLTDNKRESWLRDLANPAVPLRRLSRTIPHGIRGKVLLDQCLGKRVPVARAVWLAKCVGANEIRAFKRKGTSGPLAIGLEAKWVRDWTVNVQQFLESVIAACGTADWKMKMTYAVSLIARLFHENLLDHDHYIGWFLSCLEAAPLKTLPVWLLMLGIYWDSIMRYRKRGCRLAELLLAKLIQVSKSEHAGALKPLIDRLSLYVKRLVREHTSSAILPTSWATYRDFVSSSLDLDDKVDRAIFQSIAERNVRVQRPMRCQSAAHRSGQQQQQHIIRLFDSIRTAHDVSSVSVVCLDTFEDRATLIYKLLEWTATPFRHGLRRVYIAVRLLRKWKMAGIDVDSHILGFLSDSPKANENMDMVYHAISELVRSQTFSVGRYLQWLMAKGVSRDSLSDHRVIPGGVGLLSQLPVSHLPEHVSNLRDTLLVRVGIASSEEATIISQVKSSIATRLPKVFGGFETGSIPDASYQSLTWAVKSEIGQWIRRAVAQHCRDPTKSISGVPFLADLKVSSLTPDEFYKIRSLLESFGDISMLADVVKQAASSDDNIVLASAADTVNYHCDSFNVIGAATDLFRRLVDAYSLLKRLGTADLDLIYSLIELGLQLPNEYNTVGILRQDLSRIENRSAQAAPSPLSDHIPDTVNETDSSFLEKLDQFLSSGSGMDEPTMDAIFDALVKILDMGDGQTKLSANDACRYLAHLRPFHPKHFDTRLVRWVCGALKMSDRAEFFKSLPPLIGVGCVTIQAFLSLVKKLLQVKPASIPNVDELQMDLFELLAPSATQDGCRDLVTYRFYLAQHEFRTKHLEETLEVIRGAVASIGQKEGLSSGPTRNHLETSMVILLCDLLTNEPGNAAQQSMQKLTDQHPAFLVALQNALDRLLGLDSPGQAENNLSEAERVISMTSDFSLPFCQLKLQMLFNAASGEEVKNGVVDVMFKMAVEDSRSKRSNWVGLVTLMNQDAVRQIRERAEKEFLSVPMLPLEASVDEDGSPSVNYTNAIETARIYLMIIEELAYSVPESGVPSIAPVLVEKMDLLLNKFVIMQTNSTNFAENRNDTSEGGQQNTARSNFERGLAFWFSVLLRMVVIHRSAFTSSIRPTGLQEQTRILISIFSIALARFPNSLLRLFPTADYFPRPHQPEDYRPCPGILLQTHALDVAASLIDTFPDEARHHCARFLKEKCPPFAQFQNDSRFIYLLGPLPGYGAAANSAQPASLPSPAASGSTPTPSQAQATAAAAPSPGLSAGVSSAEGPNCSLRLQHRGRIVGAYQIRPWELLEDAAPLAGVNDTAISLRYFDARRIRA
Length1587
PositionKinase
OrganismAspergillus cristatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.204
Instability index46.56
Isoelectric point8.41
Molecular weight174736.12
Publications
PubMed=27267057

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10076
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     639.11|     153|     319|    1065|    1217|       1
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 1065- 1217 (241.02/141.17)	PSATQDGCR..DLVTYRFYLAQHEFRTKHLEETLEVIRGAVASIGQKEGLSSGPTRNHLETSMVILLCDLLTNEPGNAAQQSMQKLTDQHPAFLVALQN..ALDRLLG.LDSP....GQAENNLSEAERVISMTSDF..SLPF...CQLKLQMLFNAASGEEVKNGV
 1227- 1381 (177.51/101.81)	EDSRSKRSNwvGLVTLMNQDAVRQIRERAEKEFLSVPMLPLEASVDEDGSPSVNYTNAIETARIYLM..IIEELAYSVPESGVPSIA...PVLVEKMDL..LLNKFVI.MQTNstnfAENRNDTSEGGQQNTARSNFerGLAFwfsVLLRMVVIHRSAFTSSI....
 1383- 1531 (220.58/128.50)	PTGLQEQTR..ILISI.FSIALARFPNSLLR..LFPTADYFPRPHQPEDYRPCPG.ILLQTHALDVAASLIDTFPDEARHHCARFLKEKCPPF.AQFQNdsRFIYLLGpLPGY....GAAANSAQPA.SLPSPAASG..STP....TPSQAQATAAAAPSPGLSAGV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     428.04|      84|     320|     636|     719|       2
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  636-  719 (140.31/81.73)	FLSDS.....PKANE.NM...DMVYHA...ISELVRSQT.FSVG...RYLQWLMAKGVSRDSLS..DHRVIPGGVGLLSQLPVSHL.PEHVSNLRDTLLVRVG
  739-  817 (108.59/61.49)	RLPKV.....FGGFE.TGsipDASYQS...LTWAVKSE....IG......QWI.RRAVAQHCRD..PTKSI.SGVPFLADLKVSSLtPDEFYKIR.SLLESFG
  864-  935 (75.48/40.35)	RLVDAysllkRLGTA.DL...DLIYSL...I.ELGLQLP....N...EY....NTVGILRQDLSriENRSAQAAPSPLSD....HI.PDTVNETDS.......
  944- 1027 (103.66/58.34)	FLSSG.....SGMDEpTM...DAIFDAlvkILDMGDGQTkLSANdacRYLAHLRP...FHPKHF..DTRLVRWVCG...ALKMSDR.AEFFKSLPP..LIGVG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     226.73|      42|      43|      79|     120|       3
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    8-   53 (54.96/27.75)	GAQPRGQHPLRavnT.ASGQ.PNTFQ.AFAQSEA...nlP...TPVSQAQ..FRQQP
   54-   91 (47.49/22.83)	TVIDLTGGE............DAQEREPPAK..RprldiP...TGTSSRT..ASPVP
   92-  135 (71.84/38.87)	GVSGVGGGDLR...S.APGG.PTTPRPPSTTSWR...grP...VWSFQSL..VSETP
  136-  183 (52.44/26.08)	GVGDVNGDNAA...AlAQGGkPASPPPLPTPPWR......faqRSSSSRSedNSPVK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     432.31|     136|     222|     253|     399|       4
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  254-  359 (141.56/101.47)	.............................................................................HRSGLQMLSSVFaSAFEK.RQGHN...TVATS....STFKPPPRVTLTDNKRESWLRDLANPAVPLRRLSRTIPHGIRGkVLLDQCLGKRvpvARAVWLAKCVGANEIRAFKRK
  360-  477 (175.47/121.85)	GTSGPLaIGLEAKWVRDWtvnVQQFLESVIAACGTADWK..............................................................mkmTYAVS....LIARLFHENLLDHDHYIGWFLSCLE.AAPLKTL..PVWLLMLG.IYWDSIMRYR...KRGCRLAELLLAKLIQVSKSE
  480-  617 (115.27/67.91)	GALKPL.IDRLSLYVKRL...VREHTSSAILPTSWATYRdfvsssldlddkvdraifqsiaernvrvqrpmrcqsaaHRSGQQQQQHII.RLFDSiRTAHD...VSSVSvvclDTFE..DRATLI.YKLLEW......TATPFRHGLRRVYIAVR....................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10076 with Med12 domain of Kingdom Fungi
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