<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10073

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNVNVGGAGQEPGIHESKNGLSNPGGPGSSTELRNGATHVNGVSGTASDQLWKEEASAASGEPPALMHITQGFFPFSMLVNRSVQQCWNDLSELIAELAEMQVPSQDQSSFTPHGKSSGNQNSANVQKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDLQGFIRTRHQAYAGALQWVGDMKRDLVMAQVANPDLKTALEVLSRGRVMAMSDLGYKPPKPLTAKRTLKKLQKLNKIISIRLTLHDQVPRAFQTYRVHDGRVTFSVPGEFELDLSVGEENKSSQFFFVDIRFLFSPSSAIPKGRVLNELDIRINDVLRDSGLTGCFDLLHSLVLTFKINVLFKQAIDLARGLWSDVLRVELLHRTLIVQYWALQLGAKSWLEVGIKSGRRRGSHGNPGVPCLGLRWMRDGQEVGNADIEFDTENLSMECLLRSVIALHVSHILSSVYTSVSENSLFSTGTLSLRAQLSRIEPGDCQLDIQLTASRRLRVTIEPMSGASILSAAPSILDRPDSDRGPDKSLTDEIASRVARIRCSSAIEEIESNLRILGFETVNPRFLKVDIRRIFPSNVIRFTFFRHHLWEPNWLIAATSSMDSDNWWVIQLRATLSANKHPTLGAQNTSMLRSAQVISSRFLAAQQHTSYAACADLGHCLTGILAIYANARFLAELQCIHFHPPLHKLQIETGLRTPDIFIRYEASNLPPALRIAQPAGLKKFYIKNTIRVSFHGVDPHKNLAILVAYGSLAMPVKSLGTLVSKWDPSIVFRQKGGGFAIRLLAPAGQVVIVDLIEKLQRLERILSIIESLQRKKMDVLSLSLSRIAFSYGPGKALRANINVNTSGPSSSADTDLAGIPSKAESVFLQRLGIAFDYPNPHRRIQESLTTSLNSASSEAGLDSFFELLTLTLPLLRALDQITINPSHNEPLKAQVTVRNAKTYQIHYPIAKFRFQLVAGQHLNRMTWILKDVSGTQDRSHQNQITGSLREKLYNAKGDGWRGLGTGMVAEVDKVSNLILELDGCFSDSRSTIATPGHSAVGHGTRNVGQQQAVGQGGPGQTSKAGVPSSRGLPAVGAPGRKPEQKASDDVIMID
Length1094
PositionTail
OrganismAspergillus cristatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.158
Instability index44.42
Isoelectric point9.44
Molecular weight120281.32
Publications
PubMed=27267057

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10073
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     965.30|     322|     373|     296|     663|       1
---------------------------------------------------------------------------
  296-  663 (502.03/480.08)	FFVDIRFL.FSPssaiPKGRVLNELDIRINDVL...RDSGLTGCFDL.....LHSLVLTFKINVLFkQAIDLarglwsdvlrvellHRTL..IVQYWALQLGAKS.......WlEVGIkSGRRRGshGNPGVPCL...GLRWMRDGQEvgnaDIEFDTENLS.MECLLR...SVIALHVSHILSSvytsvsenslfSTGTLSLRAQLSRIEPG.DCQLDIQLTAsrrlrvtIePMSGASILSAAPSI.LDRPDSDRGPDKSLTDEIASRVARIRCSSAIEEIE...SNLRILGFETVNPRF...LKVDIR.RIFPSNVIRFTF..FR......HHLWEPNWL...IAATSSMDSDNWWVIQLRATLSANKHPTLGAQNTSMLRSAQVISSRFLAAQQ..HTSYAACADLGHCLTG
  673- 1041 (463.27/343.86)	FLAELQCIhFHP....PLHKLQIETGLRTPDIFiryEASNLPPALRIaqpagLKKFYIKNTIRVSF.HGVDP..............HKNLaiLVAYGSLAMPVKSlgtlvskW.DPSI.VFRQKG..GGFAIRLLapaGQVVIVDLIE....KLQRLERILSiIESLQRkkmDVLSLSLSRIAFS...........YGPGKALRANINVNTSGpSSSADTDLAG.......I.PSKAESVFLQRLGIaFDYPNPHRRIQESLTTSLNSASSEAGLDSFFELLTltlPLLRALDQITINPSHnepLKAQVTvRNAKTYQIHYPIakFRfqlvagQHLNRMTWIlkdVSGTQDRSHQNQITGSLREKLYNAKGDGWRGLGTGMVAEVDKVSNLILELDGcfSDSRSTIATPGHSAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.73|      11|      14|      22|      32|       3
---------------------------------------------------------------------------
   22-   32 (20.03/12.57)	ESKNGLSNPGG
   38-   48 (19.70/12.22)	ELRNGATHVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.51|       8|      29|     157|     167|       5
---------------------------------------------------------------------------
  157-  167 (10.45/14.21)	QWsrqAADVSR
  187-  194 (17.06/10.15)	QW...VGDMKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.62|      11|      17|     251|     263|       7
---------------------------------------------------------------------------
  251-  263 (15.13/15.99)	RLTLhdQVPRAFQ
  271-  281 (20.48/12.17)	RVTF..SVPGEFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10073 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) STIATPGHSAVGHGTRNVGQQQAVGQGGPGQTSKAGVPSSRGLPAVGAPGRKPEQKASDDVIMI
2) VVMDNVNVGGAGQEPGIHESKNGLSNPGGPGSSTELRNGATHVNGVSGTASDQLWKEEASAASGEPP
1030
4
1093
70










Molecular Recognition Features






MoRF SequenceStartStop




NANANA