Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | MEAQPPEQPQQQPSPTLTNPRFTLELEFVSSLANPYYLSHLAVTYPNLLGISRSSDETGNEDTDTPADPDAQAFAAYLAYLYSYWKTPEYAQFLTHPGPTLRALRLLQEETFRRDVIRPQVIEGLAGLGLVGEQQQQQQEGAQEGGDEQGQEGAEKQDGV |
Length | 160 |
Position | Middle |
Organism | Aspergillus cristatus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.719 |
Instability index | 59.55 |
Isoelectric point | 4.25 |
Molecular weight | 17754.21 |
Publications | PubMed=27267057 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription, DNA-templated GO:0006355 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10071 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 218.66| 67| 81| 4| 72| 1 --------------------------------------------------------------------------- 4- 72 (112.56/62.28) QPPEQPQ..QQPSPTLTNPRFTLELEFVSSLANPYYLSHLAVTypNLLGISRSSDETG.NEDTDTPADPDAQ 86- 155 (106.10/53.05) KTPEYAQflTHPGPTLRALRLLQEETFRRDVIRPQVIEGLAGL..GLVGEQQQQQQEGaQEGGDEQGQEGAE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DPDAQAFAAYLAYLYSY 2) QEGGDEQGQEGAEKQDGV | 68 143 | 84 160 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab