<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10070

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGNITNVHVIDGFSSIHWRIYTEEPGITNHPSEAPTNGHTILKHLSRLKDLELRLRNLGCLVSCYPRRLGLWIFSPNSNFDSLAPLSQSNDGLSRLQVGSLTLKVSASGSVSSRELVRTLSAEPQAPNVNTAGSQRSQNVPNPPRRIEGYGTSAAIYASFISAVTGAISLQLIRRHGAIPLGSRTLFTAVEKDGYETRIANDSPIAIPSLSTLHIQLTSGGKLTVALQTIAQHGMSRLQSPKNDPDEPRDAQPGLDIWLSPSGTVARLVSFSASTQDSISPNASGSNGTLGLAAAKRTQWKQSVLEWLGNFGLPVDSHEENLWIEVEVWEPFYSRLAGEIFRQSEEGPTALPLKRILWPARYCFRRTKSIALDASYGKEDSCHLADSPLGLAEEWHGTGNFVHEEANSIAPSGGFQNQPMRDPEISPSKAEFPEPMESLSRIAQYPDLQATSLVYPTPPDGATAISSDVFADQPDLPLPQSQLGDQQKPKQASFKEQSDPDIPIGFGPSAGLTVGSGLYDTNGDDDLFGEMNDRDFGTRGITDADFSFFDDPDFEDMGGASATDHIQSSPNIAETNLEEDNEQPSPDVPLPDIHVPTTVEETNAPQTDVAEQEAEIPSTKQETPKAHMSSPREENSQPISPPLSPVEVKKILFSGPDDGDQSTIKREKKQSHFTPVSFKQNIGDWNQKYGAEGRFWFSAPGTSTAMEPVNPPSDIPTIGLPRRSGKAAVKFDNAAKVTDEQDILSGGAKGSLHSTSDSSSVSSEDDDSDEVMSERERSPVNLTRKRKRAQSNTSGSVAQALEHPLIENPQLVSANKAENSTFLGNLLSTFSDWSLLGYFSVSQNQHPPTISQKEEQIQVAQLLVDQITQSSLDHVFDGKVGLSGLDNEMYPLRNILEDTVFTDEVDRLDLKGYASLQHGSPSLPTSDGLTPRQVPQRKDAAKGVISKLLPPHLRIRRGKDYLEALPPAVSFWETFDLEPAHGPKDISAYCIHPRATADAADAFLERLGLLYSACNLGNHVRGDMCFESGLGSWNMELSGSSNYRSTMQSLRDLCKELGDALSGSQSRTENFVVYVINPFTHAAALADICAAFWQLFQKYIMGTDKQQVGKLNELVLQIIPISFVMSPESIVVPSQSDYLSLALEVYSRCPPKDSESNLVHCAPPVLLTEPGPKAINFKLVPERLSPLQDGKSLHIACSRSLDQRWITVAWSDNTGALQRMMSYCLRYRNSGAARGISDVRNEIWGATQTIMDRIQARWKIIIVNTEPVDQDELDTWTNLAEQHNKSKSIPLELMILHVNATTDFSLEPPSLLIPTSVFNAQASSTPVATPGPSAASPDQYGNATTPTSGGNAPMSAATPDVQPESELDFFLTDIRDESWGVILSHRLNSSPHLTEYRPALASGYLLRRKGPTDGDGVFATNVNLIYAQRPTSSHGALLKEVLGMYHDLAILARARGTRCVQRNTLPWHIATAVRAQELLSYVF
Length1487
PositionKinase
OrganismAspergillus cristatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.414
Instability index54.03
Isoelectric point5.11
Molecular weight162373.46
Publications
PubMed=27267057

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10070
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.39|      48|      51|     489|     539|       1
---------------------------------------------------------------------------
  431-  481 (65.50/35.63)	....PSKAEFPEPMESLS.RIAQYP..DLQATS..LVYPTPPDGataissDVFADQPDLP
  489-  539 (83.00/55.61)	DqqkPKQASFKEQSDPDI.PIGFGPSAGLTVGS..GLYDTNGDD......DLFGEMNDRD
  547-  584 (41.89/20.26)	D......ADFSFFDDPDFeDMG.GASATDHIQSspNIAETNLEE......D.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.12|      44|     406|     183|     321|       2
---------------------------------------------------------------------------
  238-  289 (69.58/102.72)	GMSRLQSPKNDP.DEPRDAQPgldiwlSPSGTVArlVSFSAST.....QDSISPNASG
  705-  754 (69.54/11.02)	GTSTAMEPVNPPsDIPTIGLP......RRSGKAA..VKFDNAAkvtdeQDILSGGAKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.36|      37|     407|     987|    1023|       4
---------------------------------------------------------------------------
  987- 1023 (64.72/43.29)	PKDISAYCIHPRATADAADAFLERLGLLYSACNLGNH
 1402- 1438 (63.65/42.44)	PALASGYLLRRKGPTDGDGVFATNVNLIYAQRPTSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.66|      30|     407|     183|     213|       5
---------------------------------------------------------------------------
  183-  213 (47.31/34.08)	IPLGSRTLFTAVEK.DGYETRIAnDSPIAIPS
  592-  622 (48.35/29.93)	VPLPDIHVPTTVEEtNAPQTDVA.EQEAEIPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.84|      47|      48|      36|      83|       9
---------------------------------------------------------------------------
   29-   79 (70.54/42.24)	PGiTNhpSEAP.TNGHTILKHLsRLKDLELRLRNLGCLVS.CYPRRLGLWIFS
   80-  130 (61.29/32.39)	PN.SNfdSLAPlSQSNDGLSRL.QVGSLTLKVSASGSVSSrELVRTLSAEPQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10070 with Med13 domain of Kingdom Fungi
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