<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10068

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSASLVAWQTFLARCIKSRLDPETFTTYLEVLENQAPLPAPRIVNLFLAPREGSDFVPDPLVLQYVQILLSSGKVNVPTLLRGLWKVSSFRDLVDGGDEAQKEGAEEAVEKKATGRWKSSYTTEETLFYRITKNISTGTAPRDLQETVELISICIQWMDTVLAASQTAHTMLNLSQAHAAEMNAQHMALGTLVIAVVENARVVHALGRRAVPRPARKKLGKALEGFVPLLLQSNGPAAARLEVFRADTLVALEPIEIKEPKAGAEKDIEDILADGLQLGVDSMVVEEMPVINTRAGLYVYFNSLLVARPLIDDNAIFAYLHNRYQGDIRSTMIGIILAAFDILANAQFRNERASTSILRSFLINKIPLLLSSLSSSLFPPLTPEYCITEALSHVDTNAFPTISNMFDETPSSNIFSDSVRTDFCFACCLHGLIEESNIVELLGDEPMQSLPAGGRYVKDDLIQQCLSDPERAERLIDELQLMDGNVGAASQAIVEVIARLCSNKETMSLKGLCSKLVRIPSSLDVILLFDKPASFLQPICDLLDNWSYDEDQGEYQPVYEEFGSILLLVLSFANRYNLSTVDIGIRNQDSFVARLLNQGHLSRKMEILPETEQTHLDGWIKGLFDNESGGLGDELMSSCPPQDFYLLVPTLFHEIVLGVSTKNLSEEALKGGLEYLVDTFLLPALVPGITWLAAHLWESRESSKAVLQILSALITSSTSISNNTEASQMLNSILNIVAKKLEHSLRWLQRAEPSRQDIEPLSKIVRDNLNWERTGAAGHTELESWTAQASGGLAVSVKTTLAGLVLWGVNPTLNSSPANYTHRQILAAVKMLTAQRVLGALIEELKAQTATGNGSVALDAACAIVCAPEAASWETGMQTDIMGASTITPLQRRMTLREALKIAADGTPKMHKTDPFTAETIVRLYRKVEAQMIMPMPQHDALGALGLSTSIEEAVDAMANDALHGDRLGDGMGGGTDLDLGLGMGDANGDLMQGLMGGSGDLGDDLLGFGGSDGMGF
Length1017
PositionTail
OrganismRhynchosporium commune
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Rhynchosporium.
Aromaticity0.06
Grand average of hydropathy0.020
Instability index45.54
Isoelectric point4.82
Molecular weight110712.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10068
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.83|      20|      23|     965|     985|       1
---------------------------------------------------------------------------
  965-  985 (36.29/26.15)	GDRLGDGMGGGTDL..DLgLGMG
  989- 1010 (35.54/20.31)	GDLMQGLMGGSGDLgdDL.LGFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.26|      21|      25|     739|     759|       2
---------------------------------------------------------------------------
  739-  759 (35.23/21.21)	KKLEHSLRWLQRAEPSRQDIE
  763-  783 (35.02/21.04)	KIVRDNLNWERTGAAGHTELE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.55|      21|     168|      37|      64|       3
---------------------------------------------------------------------------
   37-   64 (25.35/36.11)	PLPAPRIVNLFLaprEGsdFVpdPLVLQ
  212-  232 (39.20/23.90)	PRPARKKLGKAL...EG..FV..PLLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.34|      38|     157|     434|     482|       4
---------------------------------------------------------------------------
  441-  480 (61.28/55.18)	LLGDEP.MQSLPAggRYVKDDLIQ..QCLSDPERAERLIDELQ
  806-  846 (56.06/25.04)	LWGVNPtLNSSPA..NYTHRQILAavKMLTAQRVLGALIEELK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.84|      52|     285|     601|     668|       5
---------------------------------------------------------------------------
   79-  146 (71.11/35.53)	TLLRGlWKVSSFRDLVDG.GDEAQKEGAEEAVekkatgrwkssYTTEETLFYRITKNISTgtapRDLQE
  614-  666 (90.73/56.14)	THLDG.WIKGLFDNESGGlGDELMSSCPPQDF...........YLLVPTLFHEIVLGVST....KNLSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.55|      17|      18|     275|     292|       6
---------------------------------------------------------------------------
  275-  292 (24.80/20.67)	GLQLGVDSMVVEEmPVIN
  296-  312 (29.75/19.15)	GLYVYFNSLLVAR.PLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.70|      22|      25|     897|     918|       7
---------------------------------------------------------------------------
  870-  884 (21.42/ 8.49)	......AASWETGM.QTDIMGA
  897-  918 (37.37/19.32)	REALKIAADGTPKMHKTDPFTA
  923-  944 (38.91/20.37)	RLYRKVEAQMIMPMPQHDALGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      12|      18|     370|     381|       8
---------------------------------------------------------------------------
  370-  381 (20.35/12.62)	LSSLSSSLFPPL
  391-  402 (21.44/13.72)	LSHVDTNAFPTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.98|      11|      18|     529|     539|       9
---------------------------------------------------------------------------
  529-  539 (20.05/12.14)	FDKPASFLQPI
  548-  558 (20.92/12.98)	YDEDQGEYQPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.30|      17|      26|     315|     331|      10
---------------------------------------------------------------------------
  315-  331 (30.91/21.09)	AIFAYLHN.RYQGDIRST
  338-  355 (24.38/15.20)	AAFDILANaQFRNERAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.41|      25|      26|     684|     709|      11
---------------------------------------------------------------------------
  684-  709 (35.85/34.69)	ALVPGITWLAAHLwESRESSKAVLQI
  712-  736 (38.56/29.33)	ALITSSTSISNNT.EASQMLNSILNI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10068 with Med5 domain of Kingdom Fungi
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