<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10061

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDHRSSNGSHTNHDRHQRPNGSNEAMEKMQEKGKAREPYHSTAQPGSTMLNGLNGKMPEYLRHGDAKIDHSQNLKAHMNRLPEEIAHIAENYFPLSTLISRLAQKTHVDVLNTIQELGQMPAPVSAVNGNASYHGSVEDSSTENVSKKLRLLNFATSSHEAWTKALVITGWSRKAEEVTHLIDVRIHLEAQKQLYTQAIDLMAENKRALHNFRLPNPDLKTALEVLTTGKASWMPDLNYIQPPPLTAKEVLRSLEKLNTLLSIRLNLNDYESIPWQFKDFTIKSGRVTFTVPGEFEIDLTIADEDPESQYWYIDFRFCFQPSSASMSPGIRWHLENKVNEILLKDGLSGCYKYLHELILTYKINEFRRQAVTLARSTWIDTLRVEILNRPISIQYWLNRYSDHRNPKGVLTKGTKSWIILGVHSGKRKDGRQDPKATSRLFIRWFRESKEVKDVDVPFDVTNISAESLLKSIVAKHIDYILTSIYTNLVVKPLFANRELELSLKISHDNPTTSELRIQLTNEQHVTIRIDPISGRFVFGPMGRTFATFEAGLNDRIRDPANEGHTWIERLRMFLITEDLTTRALSVGWNKIGNPELRYDKVQQFAGKNHLGVVWFRRNGWLKDWYLAVSQSMSGETWYLVKTFVPAPKIYVSQAYPHSALVPTSIEPKNREVACAVKLPIKAHSPKPTYSFLSTLNIFAAGVASHYSNMKTLHAKHVHHMLGKGRASKGLTLPSIFAKFSELIPSKNRLPRTGKPWAKDIIRISFQGVEMAQQDSLDIANLDSPEKTPGYPSPNMPPASEYSVAERSVLITEAHMLVPLPQALLNINEQVDKDIVFNARNETFAIRLHSRVGESVIPALVERLVRVERLVEFVQVLDRYEKSLTCETVSLGRIVFTYRNNPAHDSIDAADIGFMSDLYRATIDFSAADNVMALLLERGNPHLRISDILSRILNGSEGLDGIATFLPLTLPVLRGFDAIEKAWDSDDLSGLGEVFINVRAQGAFDVPESVPWWYVRRSDDPARNKGEDALDQDFKILWKSSGPGWQGMSVSGVAQGAGAEILLVKIDEVVRAFALSGKSLDSIAQAPIPGPQKQAPVLNGRQQQQQQHRQQQPLPNMNQNQIQTQGRNNALKREVVEID
Length1138
PositionTail
OrganismRhynchosporium commune
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Rhynchosporium.
Aromaticity0.08
Grand average of hydropathy-0.390
Instability index41.73
Isoelectric point8.72
Molecular weight128521.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10061
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     313.75|     109|     129|     708|     831|       1
---------------------------------------------------------------------------
  708-  831 (163.52/145.75)	NmKTLhAKHVHHMLGKGraskglTLPSI...FAKFSELIPSKNRLPRTGKPWAKDII...RISFQGVEMAQQDSLDIANLdspektpGYPSPNMPPASEYSVAERSV.LITE...AHMLV.PLPQALLNINEQVD
  840-  959 (150.23/99.64)	N.ETF.AIRLHSRVGES......VIPALverLVRVERLVEFVQVLDRYEKSLTCETVslgRIVFTYRNNPAHDSIDAADI.......GFMSDLYRATIDFSAADNVMaLLLErgnPHLRIsDILSRILNGSEGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.25|      42|      50|       7|      56|       2
---------------------------------------------------------------------------
   11-   56 (71.91/57.69)	TNHDRH...QRPNGSN.EA.MEKMQEK.GKAREPYHstaqPGSTMLNGLNGK
   58-  105 (55.34/27.70)	PEYLRHgdaKIDHSQNlKAhMNRLPEEiAHIAENYF....PLSTLISRLAQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.68|      34|      53|     494|     528|       4
---------------------------------------------------------------------------
  494-  528 (52.89/40.38)	FANRELELSLKI...SHDNPTTSE.LRIQLTNEQhVTIR
  545-  582 (50.80/33.20)	FATFEAGLNDRIrdpANEGHTWIErLRMFLITED.LTTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.02|      34|      42|     340|     379|       8
---------------------------------------------------------------------------
  340-  379 (45.55/52.18)	EILLKDgLSGCYkYLHEliltYKINEFRRQAVTLARSTWI
  385-  418 (62.47/45.60)	EILNRP.ISIQY.WLNR....YSDHRNPKGVLTKGTKSWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.11|      64|     169|     427|     492|      10
---------------------------------------------------------------------------
  427-  492 (100.27/69.16)	RKDGRQDPKATSRLFIRWFRESKEVKDVDVPFDvTNISAES..LLKSIVAKHIDYIlTSIYTN..LV...VKP
  597-  667 (101.84/62.21)	RYDKVQQFAGKNHLGVVWFRRNGWLKDWYLAVS.QSMSGETwyLVKTFVPAPKIYV.SQAYPHsaLVptsIEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.72|      50|      78|     173|     224|      12
---------------------------------------------------------------------------
  173-  217 (56.90/39.81)	..................................RK.AEEVTHLIDVRIHLEAQKQLYTQAIDLMAENKRAlhNFRLPNP
  218-  294 (62.88/37.78)	DLKTALEvlttgkaswmpdlnyiqpppltakevlRS.LEKLNTLLSIRLNLNDYESIPWQFKDFTIKSGRV..TFTVPGE
  298-  337 (55.95/32.23)	DLTIADE.............................dPESQYWYIDFRFCFQPSSASMSPGIRWHLENK...........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10061 with Med14 domain of Kingdom Fungi
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