<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10060

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPSEYPTNVISFNNFVSISYEYVELQATSPGSARKQLQKVEARWRQDGRLVHYDPYREGIWIFRRVTVPNGSPTKESEFSNMSVESQGLGVVRREMGTYEPASLARSKQHSGNSVSAGSASSSPSSSLDATLRNAQIFNAKSIQTNANLNMMQEPSASSPGAKLESMTSPKDINEYFISAVLSSVVYFLCHDHDFIPLNSRTLILAAPRSSAKPGREIELATLDISLTSLGTLVIKAHSDMASGLQTLRDVFGATSTTCGLSPGTALWLAPSGSAAKFHSMPDDKNLPENLSIAQLQATSSVMKSQGVLNPLTIRSWQSRCLKWLAAKGLNPVSLEAGGWIYVQIVGGLLPYANSDSSGIPLLEELAIVPWPAVLCFQTSSSSNMRDSQVESVADCRDPLSFAEDWFTSKDERAAVISNRLKEKLVADALLNEHADGEIRALQSHSYSPVALRRGSNVGAMYPTPPDAPQPHVGATPSFDGNVSTPGNPNHSVGHEAVGALPTNPNMMDVDADLWGSSGKKDRTNSAVQYHDDNDNNNENDNANLFGDLGGDIFGTHITDDDFNFFDEPDDDFDQKPQSTVQVMGEPSIVEVKSGRHSSSADINDKDTTEIRVDMGHDQGPRPTTSKTVDTAENSQIEIETVQHPQPSINLPFNKEIIFQRLVQNPAFSTVNKQPRRTSLFRNIHFEESLQSVNEKYGSNGQFKFSDDVKYRNTGDHAGLPQTRYLTSRRKAHEGTQEMGTIARMLGEKALDGQCVLEDDPMDYLMTSDGGSPISEQDDSSRTTDDGIGESRFGLKRKWEGLEEDDMASTFDNLAMEFEQSVGTPQSMSGSQLPLLDADPADWALTSYFTSPEPDVDVEPNSLTDLERIATAQILADQAVSGTLRLPGLSPNDACVSFDRTSATKQLLNKLAKAVSSCLHDGTICSMRNYLDIQGIPVLSQALRLPPRPAPNPRNSSNLDSRTNNPFLIIPPQIEVRRSETKLSILPSSVPFWENLGLGPSKGTKDIDAVCVYPSFEGVAAHASTFLDQMRSVYESSRFGNHDKVNSNDIGNGLLPFGIDTTSQNKVHHSTVLKETAARLSRTLSSLAVGERNYVIYFVYPVDNSILLHICSAFQHLFNLYRKALAERRANTANELVLQLIPLDFIASPTSLAVPTPSKYFQLCMEVYDRCVDFKSSSSSPAIMLEQPLPRTIDFKLNPSPSASVLQENTCLHVAYAQSIDDRWITAAWTDNRGTRQMTASYCLGRKNEPISTPFTEVANEIWETTLQVVASHKIHWRIMIARVGVMDSSEIDFWTGLVSRESNFQIALTLVTVQTDPSLRLLPAWITLTPNGSGAQPVITPVSTPQALQSSILSPETGTTPIRENFGAATFAETPAELDRDSRLIDYTDQNWGAVLSHRLNNSNSLLESNPALISGYLIKRGGANATDPPIVMEVNIVHSEVLGNPRIFHESLLRELLGYYRGLGTLARARGATDAVFDIRPWHIAAAEKAVKSLYMLI
Length1501
PositionKinase
OrganismRhynchosporium commune
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Rhynchosporium.
Aromaticity0.07
Grand average of hydropathy-0.357
Instability index46.95
Isoelectric point5.18
Molecular weight164506.21
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10060
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     313.33|      97|     635|     197|     295|       3
---------------------------------------------------------------------------
   95-  181 (92.19/57.91)	.....................REMgtyEP.ASLARSKQHSGNSVSagSASSSPSSSLDaTLRNaqIFNAKSIQ..TNANLNMMQEPSASSpgAKLESMTSPKDINEYFISA
  197-  295 (157.78/112.86)	IPLNSRTLILAAPRSSAKPG.REI...EL.ATLDISLTSLGTLVI..KAHSDMASGLQ.TLRD..VFGATSTTcgLSPGTALWLAPSGSA..AKFHSMPDDKNLPENLSIA
  311-  366 (63.37/36.44)	NPLTIRSWQSRCLKWLAAKGlNPV...SLeAGGWIYVQIVGGLLP..YANSD.SSGIP.LLEE................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.84|      12|      15|     759|     772|       4
---------------------------------------------------------------------------
  759-  772 (18.51/18.14)	EDDpmDYLMTSDGG
  777-  788 (22.33/12.66)	EQD..DSSRTTDDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.73|      45|     334|     687|     737|       5
---------------------------------------------------------------------------
  687-  737 (67.22/56.34)	FEESLQSVnekYGSnGQFKFSDDVKYRNTGDhaG.LPQTRYLTSRRKAHEGT
 1027- 1072 (78.51/46.59)	FLDQMRSV...YES.SRFGNHDKVNSNDIGN..GlLPFGIDTTSQNKVHHST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.10|      13|      14|     603|     615|       6
---------------------------------------------------------------------------
  603-  615 (22.26/13.19)	DINDKDTTEIRVD
  619-  631 (23.84/14.68)	DQGPRPTTSKTVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.68|      22|    1260|      52|      76|      12
---------------------------------------------------------------------------
   52-   76 (38.74/32.21)	VHYDPYREGI..WIfrrVTVPNGSPTK
 1315- 1338 (35.94/20.95)	VQTDPSLRLLpaWI...TLTPNGSGAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10060 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DPMDYLMTSDGGSPISEQDDSSRTTDDGIGE
2) HITDDDFNFFDEPDDDFDQKPQSTVQVMGEPSIVEVKSGRHSSSADINDKDTTEIRVDMGHDQGPRPTTSKTVDTAENSQIEIETVQHPQP
3) RRGSNVGAMYPTPPDAPQPHVGATPSFDGNVSTPGNPNHSVGHEAVGALPTNPNMMDVDADLWGSSGKKDRTNSAVQYHDDNDNNNENDNANLFGDLGGDI
761
558
454
791
648
554










Molecular Recognition Features






MoRF SequenceStartStop




1) LKRKWEGL
2) YREGIWIFRRV
796
57
803
67