<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10059

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDNFLDGRFERVEKALATLITSISTYNPAPALANDLVAADAELSDGFEQLTKHQANYARILALRESSSALDNQIRETLTILTTTRRELLATPSTSLPMNGNPVSYSDLLSYARRISKYTLPPTHREPLAGDVAETGDNTPKEHSSQAQTNGTNTPIVATNGEAQNSSGMEVDSTTPAAAGQTQAAQHPGVSTNLTLWEQYLNQPADMPFVPWPTEEAIRKGALASIQVLLDQGVDPATFDPEKSAELEAERKRITEADDAAREQGRIDREDARKREMERRMSGSGAAPERREDKPKVFQLETFDDDDDDD
Length310
PositionMiddle
OrganismRhynchosporium commune
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Rhynchosporium.
Aromaticity0.05
Grand average of hydropathy-0.731
Instability index37.10
Isoelectric point4.61
Molecular weight34015.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10059
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.63|      24|      30|     134|     160|       1
---------------------------------------------------------------------------
  134-  160 (37.50/27.64)	ETGDNTPkehSSQAQTNGTNTPIVATN
  170-  193 (42.13/23.26)	EVDSTTP...AAAGQTQAAQHPGVSTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.19|      23|      27|     240|     266|       2
---------------------------------------------------------------------------
  240-  264 (29.41/32.08)	DPEKSAELEAERkRITeADDAAREQ
  268-  290 (40.79/23.80)	DREDARKREMER.RMS.GSGAAPER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.79|      27|      27|      60|      86|       3
---------------------------------------------------------------------------
   31-   55 (30.42/15.52)	..ALANDLVAAD.AELSDGFEQLTKHQA
   60-   86 (39.49/22.05)	ILALRESSSALD.NQIRETLTILTTTRR
   88-  114 (35.88/19.45)	LLATPSTSLPMNgNPVSYS.DLLSYARR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10059 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLDQGVDPATFDPEKSAELEAERKRITEADDAAREQGRIDREDARKREMERRMSGSGAAPERREDKPKVFQLETFDDDDDDD
2) TLPPTHREPLAGDVAETGDNTPKEHSSQAQTNGTNTPIVATNGEAQNSSGMEVDSTTPAAAGQTQAAQHPGVSTNLTLWEQYLNQPADMPFVPWPTEEAI
229
119
310
218










Molecular Recognition Features






MoRF SequenceStartStop




1) AERKR
2) GRIDREDARKREMERRMSGSGAAPERREDKPKVFQLETFDDDDDDD
3) LWEQYL
4) YSDLLSYARRI
249
265
196
105
253
310
201
115