<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10058

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDTIPNEFPISLRSWPSANSNDALPSIIQRINLERGGFQNITEESLREEIAREEEELNNGDNAESSSEDEEEPDKAKELNAARDEFIGQIEQAHQASMLALDFISLLLSKDAPVQASLSLSPDLQAMIGVKTLGADKLAAPRTTDAQKQDNRNVAKGLKTQHLNKAVESILASATRLEKEIEHETKYWEQVLAVSEKGWAVCRLPNQRHILGVRFGFSESSPAFKGRSLAALKRNADGTISLDQGLADAQPKSLRVRIEVNGTYTGSSTVPKAIPEESSVEALILQARNTIFSEELWQEMNRESRVLEPIRSKDSTLIYHLTDTRTLVLDLVILEEEPIQSKGPDDRIAEGIFLALNILLSSAHRLAHRRRTQPPAPIVLEKRATPPLNLLRPFITRVKHQEMMSKLRDILQPLYRVLQSIQLDTPPEYTQVSTVWAAQPNLTNAERTVSTLTDRLEVIATLTVTPTTTFSIKAQTHSQPTIFPQFFVSVSPPSSPLHMTCPPPARFETLSALQDYLYYATSCALASIFVPSPHAKSSFIHGLPSPPEPNRQSRPSSPFPSTDQHPTTQWTQTACPSTLTKSLPNTSRTKQLTFTIRSSRHYPVSAHGSPTILRVQWEYARGDSSGTDLPLLFPVEGKRSELWGDGKVAGPEGITEEEKERGVWPLTEDGGSGRGGKGEGMKRKRGLQAEGYYEWFAWVGEDDDDKGFFEVVRSLESVVESAGSVKEGEKGDE
Length733
PositionHead
OrganismRhynchosporium commune
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Rhynchosporium.
Aromaticity0.06
Grand average of hydropathy-0.502
Instability index62.28
Isoelectric point5.49
Molecular weight81277.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10058
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.59|      32|      42|     531|     567|       1
---------------------------------------------------------------------------
  531-  567 (58.27/37.18)	PSPHAKSsfihgLPSPPEPNRQS...RPSSPFP.STDQHPT
  576-  611 (46.32/20.42)	PSTLTKS.....LPNTSRTKQLTftiRSSRHYPvSAHGSPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.23|      34|     249|      16|      58|       2
---------------------------------------------------------------------------
   16-   58 (44.85/51.02)	PSANSNDALpsIIQRINlerggfqNITEESLREEIAREEEELN
  275-  308 (58.38/38.43)	PEESSVEAL..ILQARN.......TIFSEELWQEMNRESRVLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.34|      26|      26|     197|     222|       3
---------------------------------------------------------------------------
  197-  222 (47.94/30.12)	KGWAVCRLP.NQRHILGVRFGFSESSP
  225-  251 (37.40/21.93)	KGRSLAALKrNADGTISLDQGLADAQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.42|      39|      39|     432|     470|       5
---------------------------------------------------------------------------
  392-  430 (30.19/12.32)	.......RPFI.TRVkhQEMMSKLRDILQplyrVLQSIQLdTPPEYT
  432-  470 (60.77/31.08)	VSTVWAAQPNL.TNA..ERTVSTLTDRLE....VIATLTV.TPTTTF
  472-  507 (57.46/29.05)	IKAQTHSQPTIfPQF..FVSVSPPSSPLH........MTC.PPPARF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10058 with Med17 domain of Kingdom Fungi
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