<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10050

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMMMDDEMNMDDLFGDGVGLNIPSRPPTKELHQRLDELRASGCCQTIAWSKWGSIASVAANGTSLELRNLRCHPDDGTWALTEPTSTPNFSSALDGGPLKHLSWSPTGSDLAVIDAAGRVTILSMFSGLNKSGMSRLCQNDSADDLNGVVGCYWLNQAPFPPGRPAMLHGPGVKDGPIYRYDAAQAPILGPCHPVSSKSAFVCVTTNGLLRVLWQQNNGKWHESHTELESIVSSDELITHAAICSDKGGTLLIAFATSTMQLRTVRAFIDWGLPKGEKGQPAAQPLNVSIRTKHLAGTSWVPGASLDPMNPSNSDTSMIQLSHLEFLPLCADSQGGPIPATILAVRSSSPSLSSHYNPEVSSTIDRWEIQEPHQKVHPAFEQLSSRRNSTGVNPQPVAHLKKLESVTISKIAVAIEAMNNGKVIFFAYSDSSIEYRDRASMLETFNDGNLGRVWHLSQIGFSYTEDEPCLQVALSPSYCSIVQIRNDGKIKWKQLEYHLGGIGNSMEEPLYSAVVTALSLSCATSVMRNSSYDDLLATANKYATPQFTYDWLTELSRIMKVNLDYSEETHHDVLVRNTTIQLCLSVQSSLGFKGQFKPRTFAGKFSWLVLQLRNIVVLVTMAANLNIPGGPNASDRTSPLEDPEVITSLAGSVRWVLDLMAWIIDTLTTLPSSLPSTIDLSSPATLSLPDLLAYLHSTNTVSLHLLLSSPSRGFLTAILRRLQHLDYIARKAITHTSSTPNAQNPQTPTSLSPALKAAYLQIATLTTSSILKIKTIETLLSSLTSSIKLAYSSASPPLSGSPQAEKARNGLEIKMHCGSSFPDAFKSVIVELFKPGGLLEGVKEEIEPSKLFFADFEGLEVDDSPAELNVRKGKGRTMDCFRKVWLSNPPPGSAGGEGGRKSAARWRRCARCTAVMEDVPSHRQALQWLVMQQRKCFCSGYWYVLPVGEMTL
Length953
PositionTail
OrganismRhynchosporium commune
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Rhynchosporium.
Aromaticity0.07
Grand average of hydropathy-0.159
Instability index45.91
Isoelectric point6.48
Molecular weight103943.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10050
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.24|      57|     114|     625|     691|       1
---------------------------------------------------------------------------
  625-  691 (86.24/77.92)	NLNIPGGPNAsdrTSP.LEDPEV.ITSLAGSvrWVLDlmawiIDTLTTLPSSLPSTIDLS....SPATLSLPD
  742-  804 (80.00/49.13)	NAQNPQTPTS...LSPaLKAAYLqIATLTTS..SILK.....IKTIETLLSSLTSSIKLAyssaSPPLSGSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.57|      17|     114|     470|     493|       2
---------------------------------------------------------------------------
  470-  487 (26.13/31.77)	CLQVALSPSyCSIVQIRN
  514-  530 (27.43/10.32)	AVVTALSLS.CATSVMRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.29|      21|      53|      43|      63|       4
---------------------------------------------------------------------------
   43-   63 (41.74/22.41)	GCCQTIAWSKWGS.IASVAANG
   98-  119 (34.54/17.39)	GPLKHLSWSPTGSdLAVIDAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.32|      12|      40|     456|     469|       9
---------------------------------------------------------------------------
  456-  469 (19.78/19.47)	HLSQIGFSYteDEP
  499-  510 (24.54/16.22)	HLGGIGNSM..EEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10050 with Med16 domain of Kingdom Fungi
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