<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10047

Description Srb8p
SequenceMSNKNRNRNSLLSSHNRSSHTNSTSKDELLKLKYSMETPNLPIYPLNDSSIINSKTNDNLKNSPYQKPKSQSQPQAQGQSQSQPENSLVYPDFMPWKDHTQLPQDETEIEHQKLSNVSYLNKGYFEPPQVANEYYSARNLIQATVFLSTDNCTNVINELSIHLSNAYKSRNEIINKIKFDSNKFKLPTRVTLTSSKKEIWLNELSNPNVSMTKLGEKIPHGIRNKVLIDCICTKKIPINRSIWFTKCVLYGELLALRRKHQNRLSTIPNNNSNTGGGGGGGGSGNSLTGMMDYNTAEKFEIHWLQEWTQQVSDYIYKFSREMNNIANLDGKNQYMGKLSYLLNYIQSLYVESLLDKSLFLSLIMKFLKDGLCLQSKYINGLIYSSMEENSDDYNDDDDDDDDEEDANNAENPESTSKSKKRNLAWMDEIDMNYGQRLVSLTLIKMFWNDILKFDYLSKELSELLLLNYFFINKLLLFSVNNDNGNSTAVIPDGLQSKILKLISDCVRYLFEYNCNIFIIPNHWTLIEPSLMRILLSDSKAKSEKEQEEIQKQLELVKYRNESLILNLKSELNNSNNTNNSSNLGTSKRSVRSGSFSNYTTTPIKPISNTTIEQDYSFINRNSDDVLNIVEKLDNLKLNKEFASFLKPTKKCNANWKLNLKVLLFWCVSPWRNSTNSNEDILFICNFLKNTVVKSLPKSLRTEFDNELLEIIYHIAEDNNSEEGDNLQFTSSRLYVLINELYQLKLITIASYLRKLIASGIFYLEPGSTVDQSLNNLPRIMEVHLKILENLPVLNNRQCDSILKRWTPMGFDFKGKFSQGQSILQDSIITKICNNQLTDDIDSQCIGYIDSLSVGLRFLLINWLTNELKSKIKSTNKLIHFTPTVITKLYQFYAKNSGLTVFFKVVIQTILKNDGGMIIFYLDSLYLISKLVIRHYKLIKSIAGASELSAAYDLFKLIIQVYKDLNTREYDCFKFSSIWNFINAVIEKSSPTSSATTTATTSVSISSLYLTMGKPKNSKLKSVQGLHVKQTMDSPMCINTVDESHTHDTRSGAKRYTSTDFRNDLYFLVTLQPRALTSEEKQEVFDLIEIELKDLDSALEFWYNNFELLGEEKEINLMKIIKSLAVTTYNDHLSQFNEKLKQFVISKVGESIDHSKLSNFLKKLAIFDLLRINDLVKLIQSIQRDEINHIDDTISFIYELIWGELDKAHFSCSQLVLLQISRRMYQEKSSYQCIILLQQRLLKNKESQLQTNPFFIKYKADLLSFFHKAIITNTKAIQSQFFDKLSHSDSLQLLNVLLQRQENEYINTIQDFSLFIKHINEFNLPICQVLLNVLFNNLVVDNDVGIKVQLEAFVNTLLQEIKFEFSNENSFFGELFNFMPWNQKNYILDILETKFLLETNLDNNQIKLIINDRNLLPPLNDFFKKFSSSSSSSTSSSSSSLVQTIETDSSFFLNLFNFIGNLVNVANSQELILEQANSINDTISIFLRILIIHKSYLCSMISRNTNEENVILFVTKLIDLLNSDYLTNHNDKLRILLYDLLLLMKSSVSEEVNSTRELNENSQGNRNGTGTGGGGSNAISPNQDSILDDQNTNSTGIGKGQKSQIGVTNNNDMLDVAPTVSSIQVLFDLPEPNASNPFKEFIDDKLVKCSIMLEEEELKYGGDYHIFNNTGLYLKSTKNESVSLPPFVTGLNKTAGDYDSSSARMIKQPFKMKSFEILEDVNNNKNSVNDGCINLRLFDAYTTKENPR
Length1747
PositionKinase
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.356
Instability index39.86
Isoelectric point5.98
Molecular weight200063.06
Publications
PubMed=15123810
PubMed=17419877
PubMed=24025428

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10047
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     218.77|      92|     533|     847|     974|       1
---------------------------------------------------------------------------
  847-  877 (22.43/23.94)	.........................................................................................YIDSLSVGLRFLLINWL...TNELKSKIKSTNKL
  906-  972 (70.27/56.45)	IQTIlKNDGGmiiFYLDSLYLISKL..VIRHYKLIksIAGASELSAAYDLFKLIIQVYKDL.......NTREYDCF...............................................
 1441- 1557 (126.07/57.08)	VQTI.ETDSS...FFLNLFNFIGNLvnVANSQELI..LEQANSINDTISIFLRILIIHKSYlcsmisrNTNEENVIlfvtklidllnsdYLTNHNDKLRILLYDLLllmKSSVSEEVNSTREL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.56|      32|     532|     172|     204|       2
---------------------------------------------------------------------------
  172-  204 (49.81/35.98)	EIINKIKFDSNKfKLPTRVTLTSSKKEIWLNEL
  709-  740 (54.75/34.54)	EIIYHIAEDNNS.EEGDNLQFTSSRLYVLINEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.01|      43|     532|      29|      71|       3
---------------------------------------------------------------------------
   29-   71 (72.54/35.55)	LLKLKYSMETPNLPIYPLNDSSIINSKTN......DNL.KNSPYQKPKSQ
  528-  561 (34.15/12.80)	..........PSLMRILLSDSKAKSEKEQ......EEIqKQLELVKYRNE
  564-  608 (54.32/24.76)	ILNLKSELNNSN...NTNNSSNLGTSKRSvrsgsfSNY.TTTPI.KPISN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.59|      37|      55|    1115|    1157|       4
---------------------------------------------------------------------------
 1115- 1157 (46.31/46.34)	NLMKIIKSLAvttyNDHLSQFNEKLkQFVISKV.GEsIDHSKLS
 1173- 1210 (57.28/35.61)	DLVKLIQSIQ....RDEINHIDDTI.SFIYELIwGE.LDKAHFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.99|      39|      55|     981|    1021|       5
---------------------------------------------------------------------------
  981- 1021 (58.29/43.42)	INAVIE.KSSPTSSATTTATTSVSISSLY.LTMGKPKnsKLKS
 1037- 1077 (58.69/37.32)	INTVDEsHTHDTRSGAKRYTSTDFRNDLYfLVTLQPR..ALTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.71|      10|     229|     383|     392|       6
---------------------------------------------------------------------------
  383-  392 (19.68/ 9.82)	YSSMEENSDD
  615-  624 (20.02/10.12)	YSFINRNSDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.78|      27|    1288|     269|     295|       7
---------------------------------------------------------------------------
  269-  295 (53.82/32.97)	NNNS..NTGGGGGGGGSGNSLTG.....MMDYNT
 1558- 1591 (40.96/23.27)	NENSqgNRNGTGTGGGGSNAISPnqdsiLDDQNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.69|      46|    1282|      85|     135|      10
---------------------------------------------------------------------------
   85-  135 (72.79/51.28)	ENSLVYP..DFMPWKDHTQLPqD........ETEIEHQKLSNVsyLNKGYFEPPqvANEYY
 1367- 1422 (72.90/37.16)	ENSFFGElfNFMPWNQKNYIL.DiletkfllETNLDNNQIKLI..INDRNLLPP..LNDFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.53|      17|     480|     304|     320|      11
---------------------------------------------------------------------------
  304-  320 (32.52/20.20)	LQEWTQQVSDYIYKFSR
  802-  818 (34.01/21.47)	LKRWTPMGFDFKGKFSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.49|      30|      30|    1292|    1321|      15
---------------------------------------------------------------------------
 1292- 1316 (36.29/27.91)	........LL.NVLLQRQENEYINTIQDFSLFIK
 1317- 1346 (40.05/31.90)	HINEFnlpIC.QVLLNVLFN...NLVVDNDVGIK
 1348- 1366 (17.15/ 7.62)	QLEAF.....vNTLLQEIKFEFSN..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.99|      14|      16|    1214|    1229|      17
---------------------------------------------------------------------------
 1214- 1229 (19.27/19.73)	LVLLQisRRMYQEKSS
 1233- 1246 (22.72/14.93)	IILLQ..QRLLKNKES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10047 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IYPLNDSSIINSKTNDNLKNSPYQKPKSQSQPQAQGQSQSQPENSLVYPDFMPWK
2) MSNKNRNRNSLLSSHNRSSHTNSTSKDELLKLKY
3) NSTRELNENSQGNRNGTGTGGGGSNAISPNQDSILDDQNTNST
43
1
1552
97
34
1594










Molecular Recognition Features






MoRF SequenceStartStop




1) ELLKLKYS
2) LPIYPL
28
41
35
46