<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10044

Description Med15p
SequenceMNIPPNQNSLQQMGGGSNPNASWRAMYSGEERQKVVQIIINTLTELHGSNPNFNVQRLSKMAQDFEKLVYERSASKEDYLRAIKMKVHQLRVQKQQIAANQGGQINPQQRQQQQQQQISNSNSMNPVNAQNVQFLRQQAQARSQSQAQIQARQQQLRNMVNQQSQQQQQPQPQQTVQPHSQEHQQDQQNTSSQSTQQNVASGAGSGGRGNASSTQGQLPPQLVNLMRTSPIPPPLLNKMPKLPAGVNTWNQIFDLIRKRLIPPDMVPTIRDIHGMHLQLFIRQQQQKLSMQRNMNEGNNGDNLAQGPNANNNNNINTSTHNNSNPTPNNFNNLTPQQRESLLRQTRMQQQLEQQKKGQQPMQQATSSSQQQQQKQQQQQQPVSQSGQTPQLAQQSNNQQQQQQQPQITITQEDYAKYSNDALNLLAKLQQQKQMQGQINGQMKEAFIKKFIIHQKTLQYKQRLSQQATGNANVNIGPSSTNQQQLSQIPNQQQQQQQQQQQQVPQSQPHASQQSPVLQQSQPPQQAPVQNVPQGSPGLGNMATPQMKQGITSNPTNLSSPLVPQQVPVSNNNSASQNNNINRGRPVTAPANITMSSILPPLTDEVKLRLRQLIEEVSRNNVVLRDVTSLLSNQDKTTVRDSMNRIQEQYGNVDSIISYFYLLTKNGDGTKRLIQMKYMTKNILDNLHRGIYLAGPDLLEKVRSQYAKYFEYVKEQINLRRQQVLQQGGANMMSSQQQQQQQQQNMTRSQPQSQQQQQMMQNQSRNQAFMNQNQQIQQSSSNQQVNQGNWGTGTGVANNQMNLTPQLQQQQPPPPLPPQQQQQQTMQLGVNSSPVIPQQPTPIQHSMSGPQQVLVQQQQQQQQQQPPQRQQSVSKASQKSVAKTNKKGTGQGRKKKASISAGTAPTPGALPATTPGTLANAIKTPHNIPTPQIPPQTQSNKNTPSAQSPAYPVKATPSSTTPGTANHSHNPSYVYPTPEIDIFAMSSNDSKSAKRRELINIDPEKFFYASLANLLDLDDSIVNNHDIMKTSPRLSNGKPAATSPLSPKTGGEWTSEVKALAITTSFKQVDLIRELANDDFISSSPMLAIQEVEEPQSVKREHDADDDLDSLFTNKKANLDGLDFDRYLYEPVSFDEWKYFVVSSIQ
Length1145
PositionTail
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.04
Grand average of hydropathy-1.025
Instability index72.92
Isoelectric point9.85
Molecular weight128315.25
Publications
PubMed=15123810
PubMed=17419877
PubMed=24025428

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10044
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     889.67|     118|     119|     735|     852|       1
---------------------------------------------------------------------------
   89-  208 (138.47/23.60)	......QLRVQKQ.....Q....IA...ANQ...GGQINPQQ.........RQQQQQQQISNSNSM....NPVNAQNVQflrqqaQARSQ..SQAQ...IQ..........AR..........QQQLRNMVNQQSQ...QQ.................QQPQPQQTvQPHS..Q...EH.QQ...DQQNTSSQSTQQnVAS....GAGSG.GR
  209-  324 (110.65/17.23)	GNASStQGQLPPQ.....LvnlmRT...SPI...PPPLLNKM.........PK...LPAGVNTWNQ....IFD...LIR......KRLIP..PDMVptiRDihgmhlqlfiRQ..........QQQKLSMQRN..............................M.N.EGNN..G...DNLAQ...G...PNANNNNN.INT....STHNN.SN
  325-  468 (127.62/21.12)	PTPNN.FNNLTPQqreslL....RQ...TRM...QQQLEQQK.........KGQQPMQQATSSSQQqqqkQQQQQQPVS......QSGQT..PQLA...QQ..........SN..........NQQQQ...QQQPQitiTQedyakysndalnllaklQQQKQMQG.QING..QmkeAFIKKfiiHQKTLQ..YKQR.LSQ........Q.AT
  469-  539 (112.76/17.71)	GNAN...VNIGPS.....S....TN...QQQ...LSQIPNQQ.........QQ..........................................................QQ..........QQQQQQVPQSQPH...AS.................QQSPVLQ................Q...SQPPQQAPV.QN.VPQ....GSPGL.G.
  540-  669 (82.64/10.81)	...N...MA.TPQ.....M....KQgitSNPtnlSSPLVPQQvpvsnnnsaSQNNNINRG...RPV......TAPANI........TMSSilP....................pltdevklrlRQLIEEVSRNNVV...LR.................DVTSLLSN.QDKTtvR...DSMNR...IQE.QYGNVDSI.ISYfyllTKNGD.GT
  710-  793 (137.63/23.41)	EYVKE.QINLRRQ.....Q....VL...QQG...GANMMSSQ.........QQQQ.....................................................................QQQQNMTRSQPQ...SQ.................QQQQMMQN.QSRN..Q...AFMNQ...NQQIQQSSSNQQ.VNQ....GNWGT.GT
  794-  908 (179.90/33.09)	GVANN.QMNLTPQ.....L....QQ...QQP...PPPLPPQQ.........QQQQTMQLGVNSSPV....IPQQPTPIQ......HSMSG..PQQV.lvQQ..........QQ..........QQQQQ.....QP....PQ.................RQQSVSKA.SQKS..V...AKTNK...KGTGQGRKKKAS.ISA....GTAPTpGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.68|      12|      30|       8|      20|       2
---------------------------------------------------------------------------
    8-   20 (19.99/15.30)	NSLQQMgGGSNPN
   41-   52 (23.69/12.71)	NTLTEL.HGSNPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.35|      15|      20|     942|     956|       3
---------------------------------------------------------------------------
  913-  933 (18.34/ 6.93)	TPG....TlanaiKTPhNIPTPQIP
  942-  956 (28.27/15.52)	TPS....A.....QSP.AYPVKATP
  960-  977 (23.74/11.61)	TPGtanhS.....HNP.SY.VYPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.63|      30|     104|     987|    1017|       4
---------------------------------------------------------------------------
  988- 1017 (50.01/33.05)	DSKSAKRRELINIDPEKFFYAS.LANL..LDLD
 1072- 1092 (19.15/ 7.67)	.......RELANDD...FISSSpMLAI..QEVE
 1093- 1124 (44.47/23.98)	EPQSVKREHDADDDLDSLFTNK.KANLdgLDFD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10044 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IFDLIRKRLIPPDMVPTIRDIHGMHLQLFIRQQQQKLSMQRNMNEGNNGDNLAQGPNANNNNNINTSTHNNSNPTPNNFNNLTPQQRESLLRQTRMQQQLEQQKKGQQPMQQATSSSQQQQQKQQQQQQPVSQSGQTPQLAQQSNNQQQQQQQPQITITQEDYAKYSNDALNLLAKLQQQKQMQGQINGQMKEAFI
2) QVLQQGGANMMSSQQQQQQQQQNMTRSQPQSQQQQQMMQNQSRNQAFMNQNQQIQQSSSNQQVNQGNWGTGTGVANNQMNLTPQLQQQQPPPPLPPQQQQQQTMQLGVNSSPVIPQQPTPIQHSMSGPQQVLVQQQQQQQQQQPPQRQQSVSKASQKSVAKTNKKGTGQGRKKKASISAGTAPTPGALPATTPGTLANAIKTPHNIPTPQIPPQTQSNKNTPSAQSPAYPVKATPSSTTPGTANHSHNPSYVYPTPEI
3) QYKQRLSQQATGNANVNIGPSSTNQQQLSQIPNQQQQQQQQQQQQVPQSQPHASQQSPVLQQSQPPQQAPVQNVPQGSPGLGNMATPQMKQGITSNPTNLSSPLVPQQVPVSNNNSASQNNNINRGRPVTAPANITMS
4) RVQKQQIAANQGGQINPQQRQQQQQQQISNSNSMNPVNAQNVQFLRQQAQARSQSQAQIQARQQQLRNMVNQQSQQQQQPQPQQTVQPHSQEHQQDQQNTSSQSTQQNVASGAGSGGRGNASSTQGQLPPQLVNLMRTSPIPPPLLNKMPKLPA
252
722
458
91
447
979
595
244










Molecular Recognition Features






MoRF SequenceStartStop




1) GRKKKASISA
891
900