<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10031

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQKYLNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQTSAGMLLQQNNIDQKQYVQAQRGLQEAPSTSVDSTAQTGHPGIGDLQEELYQMIKSLKDQYFVELNELYNKVSIKIQQIDNQMPAQKSAEQYEKMKGFKGMLERTLHFLQVNKSNIHPGLREKIPIYERQILSILSSQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKSGMYQQLSQRNYYQQIKQGGVFPISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPGISASPLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTTQRESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKKMKRDTSAMPLNVSSAGSVNDSLKQSYGVGTPELQSTATSRVKWQRAEVNHALMEEIQEINQQLIDTELHVSEDDAESFTTSEGGKGTVIRCTFTAVAVCPSLKSVFASAQMSPILPLRLLVPASYPKCSPVLLDKFPDEQCRNSDDLSTKAKTKFSVLLRGLAEPMSLREIARTWDACARKVITEYAQQTGGGSFSSSYGCWESCVGAC
Length1129
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.796
Instability index72.41
Isoelectric point9.28
Molecular weight124712.30
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10031
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.57|      24|      24|     133|     156|       1
---------------------------------------------------------------------------
  133-  156 (44.54/11.60)	QPTQ..SVVRQ.QQHPQSMHQQSSLQQ
  158-  183 (39.01/ 9.06)	QPTQqpNIPLQ.QQQPQLMNQQSNLQQ
  301-  325 (39.01/ 9.06)	QPQQ..HMMSQfQSQPNQMQQQLGMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.83|      31|      42|     615|     655|       3
---------------------------------------------------------------------------
   42-   71 (45.19/ 7.14)	NQLIYQQQKYLNQKLQQNSLMPS.HIQQQ.........QP
  472-  505 (27.46/ 7.57)	..QAPGQQTF....QQSSGQAPSSNISQQlqtsqglqqHD
  632-  655 (43.18/ 9.38)	SQQMKQRQQMMQQIQQKQTLQPQL................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     488.25|      76|      76|     700|     775|       4
---------------------------------------------------------------------------
   72-  129 (39.76/ 6.41)	.........LLQ......ST.Q...MQSSQQ.PM.MQMSSGlqpgqtaipqtqsmtmhSA...TQSGI...............QQNPLN.....SVQQ.SVQP...........................................
  328-  383 (41.27/ 6.93)	...QTSAGMLLQ.QNnidQK.QY..VQ.AQR.GL.QEAPST.................SVdstAQTGH.PGigD........LQEELYQ.....MIK.................................................
  507-  564 (83.05/21.35)	HTSQMPQASL..PSM...NT.G...VQTS.......GAPAP.................QG...TNFGV.P...T........TQQN.VT.....NAPQAG........SN..LENAQ........................GNNFN
  565-  659 (76.48/19.08)	HVQHGSMGAALQ.QE...RT.G.P.MQGALN.AQ.QQSSSN.................MIsnnAMSTM.QT..N......nnANANSLQ.....QLKQ....QRQ.EHQM..MQ...sqqmkqrqqmmqqiqqkqtlqpqlP.IQQ
  660-  731 (92.52/24.61)	LKKQ.......QQQG...QM.QFPqLHSGNDvNE.LKVRQG.................AA...IKSGMyQQ..L........SQRNYYQ.....QIKQGGVFPIS.SPQT..LQTSS........................PQISH
  732-  814 (103.34/28.35)	HSPQVDQHSLLQSQV...KT.GTP.LHSANS.PF.VPSPSP.................PV...APSPM.PM..D........SDKPLSNlssvtSAGQAGHQQTSlAPQTqsIAVNT........................PGIS.
  815-  884 (51.83/10.58)	ASP......LLAEFT...SAdGSP....ANV.PTqVPAKS..................SA...AER...PL..DrllkalrtTQRESLS.aavsDI..GSV..VS.MIDR..IAGSA........................P....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.07|      51|     578|     417|     471|       8
---------------------------------------------------------------------------
  417-  471 (78.90/65.31)	AEQYEKMKGFKGMLERTLhFLQVnksNIHPGLR......EKIPIYERQILSILSSQRRKPV
  995- 1051 (84.17/56.20)	AESFTTSEGGKGTVIRCT.FTAV...AVCPSLKsvfasaQMSPILPLRLLVPASYPKCSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.97|      18|      78|     184|     201|       9
---------------------------------------------------------------------------
  184-  201 (33.26/12.29)	NQLMN..QQSGVVETQQQQR
  261-  280 (28.71/ 9.40)	NARMHmlQQQKVIQQPQQQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10031 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLI
2) PISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTP
3) PLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTT
4) QKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQ
5) SQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKS
1
715
817
54
465
45
811
857
328
693










Molecular Recognition Features






MoRF SequenceStartStop




NANANA