<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10028

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQKYLNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQTSAGMLLQQNNIDQKQYVQAQRGLQEAPSTSVDSTAQTGHPGIGDLQEELYQMIKSLKDQYFVELNELYNKVSIKIQQIDNQMPAQKSAEQYEKMKGFKGMLERTLHFLQVNKSNIHPGLREKIPIYERQILSILSSQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKSGMYQQLSQRNYYQQIKQGGVFPISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPGISASPLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTTQRESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKKMKRDTSAMPLNVSSAGSVNDSLKQSYGVGTPELQSTATSRVKWQRAEVNHALMEEIQEINQQLIDTELHVSEDDAESFTTSEGGKGTVIRCTFTAVAVCPSLKSVFASAQMSPILPLRLLVPASYPKCSPVLLDKFPDEQCRNSDDLSTKAKTKFSVLLRGLAEPMSLREIARTWDACARKVITEYAQQTGGGSFSSSYGCWESCVGAC
Length1260
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.772
Instability index71.15
Isoelectric point9.34
Molecular weight138735.92
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10028
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.30|      24|      24|     264|     287|       1
---------------------------------------------------------------------------
  264-  287 (45.71/13.34)	QPTQ..SVVRQ.QQHPQSMHQQSSLQQ
  289-  314 (38.55/ 9.72)	QPTQqpNIPLQ.QQQPQLMNQQSNLQQ
  432-  456 (37.04/ 8.96)	QPQQ..HMMSQfQSQPNQMQQQLGMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     344.42|      65|      65|      35|      99|       3
---------------------------------------------------------------------------
   30-   86 (84.37/16.32)	........IYTAA....TSQSDYL.RK......................................I..S.L.KMLSMESQTKTQQN...P.GNVQ.VIPN............QN..P..........PGP....APGL.PP.QVSNP
   87-  154 (80.85/15.38)	AQSSAIPLISQQQ....TRQSNAS.TS......................................VqgS.L.PSLGQNSSSVSQAS...TlHNMS.VMP.............QNtmN..........NGL....AQG..TP.QDMYA
  155-  231 (66.63/11.55)	AQRQMAGRQQQQQqqqaHNQLIYQ.QQ.............................................KYLNQ....KLQQNslmP.SHIQ....Q............QQ..PllqstqmqssQQPmmqmSSGL.QPgQTAIP
  335-  424 (59.46/ 9.62)	VQSN..NLLNMQQ....TQQMMNQ.QSmslhqpqqlanqgnmsslhqqqhqqnqqqqqllgtgpnA..R.M.HML..QQQKVIQQ....P....Q...QQ............QH..A..........QQT....SMGLiQP.Q....
  761-  829 (53.11/ 7.92)	MQSQ.....QMKQ....RQQMMQQiQQ......................................K..QtLqPQLPIQQLKKQQQ.......QGQmQFPQlhsgndvnelkvRQ..G..........AAI....KSGM.YQ.Q....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     383.62|      73|      75|     851|     923|       4
---------------------------------------------------------------------------
  608-  682 (100.43/37.59)	QT.FQQSSGQAP..SSNISQ........QLQTSQ.GLQQHDSHTSQ.MPQASLPSmntgvqtsgAPAPQGTNF.............GVPTTQ.QNVTN.....APQA
  684-  754 (83.55/29.88)	SN.LENAQGNNFNH...V.QHgSMgaaLQ.QERT.G.PMQGALNAQ.QQSSSNMI......snnAMSTMQTNN.............N...ANANSLQQ.....LKQQ
  851-  923 (130.11/51.13)	QT.LQTSSPQISHHSPQVDQH.SL...LQSQVKT.GTPLHSANSPF.VPSPSPPV.........APSPMPMDS.............DKPLSNLSSVTS.....AGQA
  927- 1014 (69.54/23.49)	QTsLAPQTQSIAVNTPGISAS.PL...LAEFTSAdGSP...ANVPTqVPAKS.SA.........AER..PLDRllkalrttqreslSAAVSDIGSVVSmidriAGSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.27|      83|     577|     483|     602|       5
---------------------------------------------------------------------------
  515-  602 (128.48/111.75)	SLKDQYFVELNELYNKVS....................IKIQQIDNQM.pAQKSAEQYEKMKGFKGMLERTLhFLQVnksNIHPGLR......EKIPIYERQILSILSSQRRKPV
 1072- 1182 (120.79/51.14)	SLKQSYGVGTPELQSTATsrvkwqraevnhalmeeiqeINQQLIDTELhvSEDDAESFTTSEGGKGTVIRCT.FTAV...AVCPSLKsvfasaQMSPILPLRLLVPASYPKCSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.00|      18|      76|     243|     260|       6
---------------------------------------------------------------------------
  243-  260 (33.54/14.87)	QSGIQQNPLNSVQQSVQ...P
  480-  500 (25.45/ 9.35)	QRGLQEAPSTSVDSTAQtghP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10028 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTP
2) PLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTT
3) QKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQ
4) RKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQ
5) SQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKS
846
948
185
42
596
942
988
459
180
824










Molecular Recognition Features






MoRF SequenceStartStop




NANANA