<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10027

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKIMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQKYLNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQTSAGMLLQQNNIDQKQYVQAQRGLQEAPSTSVDSTAQTGHPGIGDLQEELYQMIKSLKDQYFVELNELYNKVSIKIQQIDNQMPAQKSAEQYEKMKGFKGMLERTLHFLQVNKSNIHPGLREKIPIYERQILSILSSQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKSGMYQQLSQRNYYQQIKQGGVFPISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPGISASPLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTTQRESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKKMKRDTSAMPLNVSSAGSVNDSLKQSYGVGTPELQSTATSRVKWQRAEVNHALMEEIQEINQQLIDTELHVSEDDAESFTTSEGGKGTVIRCTFTAVAVCPSLKSVFASAQMSPILPLRLLVPASYPKCSPVLLDKFPDEQCRNSDDLSTKAKTKFSVLLRGLAEPMSLREIARTWDACARKVITEYAQQTGGGSFSSSYGCWESCVGAC
Length1277
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.768
Instability index69.29
Isoelectric point9.29
Molecular weight140233.44
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10027
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     570.56|      65|      65|     863|     927|       3
---------------------------------------------------------------------------
   98-  151 (60.64/13.48)	SME.....SQ.TKTQQN...PGnvQViPN...........QNP.................................PG.PAPGLPPQVSN........PA...QS...................SaiPLI...S.Q.QQTR....QS
  152-  188 (42.46/ 6.59)	NAS.....T...SVQGS...LP..SL.GQ...........NSSS...............VSQAST...L.............................................................hnMS.VMPQNT.....M
  189-  263 (70.74/17.31)	N.NglaqgTP.QDMYAA...QR..QM.AG...........RQQQ................QQQQQ...AhnqliyQQQ.KYLNQKLQQ.NS.....LMPShiqQQ...................Q..PLL..QStQM.QSS...QQP
  266-  314 (63.00/14.38)	QMS.....SGlQPGQTA...IP..Q................TQS...............MTMHSA...T......QSG.IQQ.NP.QSSLQQ....TQPT...QQ...................P...NI..P..............
  402-  462 (46.95/ 8.29)	........................QL.LG...........TGPN...............ARMH.M...L......QQQ.KVIQQP.....QQ....QQHA...QQtsmgliqpqsqqnqlqqpqQ..H.M..MS.QFQ..S....QP
  625-  665 (61.44/13.78)	...........QTFQQS...SG..QA.P.............SSN...............ISQ...............Q.LQTSQGLQQHDS.......HT.................................S.QMPQAS....LP
  666-  760 (55.71/11.61)	SMN.....TG...VQTSgapAP..QG.TNfgvpttqqnvtNAPQagsnlenaqgnnfnhVQHGSMgaaL......Q.Q.ERTG.PMQGALNA....QQQS...SS................nmiS..NNA..MS.TMQTN....NNA
  863-  927 (112.14/33.01)	PIS.....SP.QTLQTS...SP..QI.SH...........HSPQ...............VDQHSL...L......QSQ.VKTGTPLHSANSP....FVPS...PS...................P..PVA..PS.PMPMDS...DKP
  930-  994 (57.48/12.28)	NLS.....S....V.TS...AG..QA.GH...............................QQTSL...A.....pQTQsIAVNTPGISA.SPllaeFTSA..dGS...................P..ANV..PT.QVPAKSsaaERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.39|      20|      29|     317|     339|       5
---------------------------------------------------------------------------
  317-  336 (37.07/ 7.08)	QQQPQLMNQQSNLQQNQLMN
  476-  495 (27.33/ 6.86)	QTSAGMLLQQNNIDQKQYVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.25|      19|      21|     525|     545|       6
---------------------------------------------------------------------------
  525-  543 (32.52/26.14)	ELYQMIKSLKDQ.....YFVELNE
  566-  589 (28.73/14.46)	EQYEKMKGFKGMlertlHFLQVNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.23|      20|      38|     765|     784|       7
---------------------------------------------------------------------------
  765-  780 (25.37/ 9.26)	........................LQQLKQQRQEHQMMQS
  781-  819 (22.84/ 7.41)	QQMKqrqqmmqqiqqkqtlqpqlpIQQLKKQQQQGQ.MQF
  820-  841 (22.03/ 6.81)	PQLH................sgndVNELK.VRQGAAI.KS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.62|      12|     203|     342|     353|      10
---------------------------------------------------------------------------
  342-  353 (20.45/ 9.20)	VETQQQQRLPVQ
  358-  369 (22.17/10.85)	LNMQQTQQMMNQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10027 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQ
2) MDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKI
3) PISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTP
4) PLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTT
5) RKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQ
6) SQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKS
231
1
863
965
90
613
476
48
959
1005
228
841










Molecular Recognition Features






MoRF SequenceStartStop




NANANA