<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10024

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKIMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQKYLNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQTSAGMLLQQNNIDQKQYVQAQRGLQEAPSTSVDSTAQTGHPGIGDLQEELYQMIKSLKDQYFVELNELYNKVSIKIQQIDNQMPAQKSAEQYEKMKGFKGMLERTLHFLQVNKSNIHPGLREKIPIYERQILSILSSQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKSGMYQQLSQRNYYQQIKQGGVFPISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPGISASPLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKARTTQRESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKKMKRDTSAMPLNVSSAGSVNDSLKQSYGVGTPELQSTATSRVKWQRAEVNHALMEEIQEINQQLIDTELHVSEDDAESFTTSEGGKGTVIRCTFTAVAVCPSLKSVFASAQMSPILPLRLLVPASYPKCSPVLLDKFPDEQCRNSDDLSTKAKTKFSVLLRGLAEPMSLREIARTWDACARKVITEYAQQTGGGSFSSSYGCWESCVGAC
Length1307
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.777
Instability index70.18
Isoelectric point9.33
Molecular weight143691.23
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10024
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.17|      24|      24|     312|     335|       1
---------------------------------------------------------------------------
  312-  335 (45.04/12.26)	QPTQ..SVVRQ.QQHPQSMHQQSSLQQ
  337-  362 (38.28/ 9.06)	QPTQqpNIPLQ.QQQPQLMNQQSNLQQ
  480-  504 (37.84/ 8.85)	QPQQ..HMMSQfQSQPNQMQQQLGMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     350.11|      65|      65|      83|     147|       3
---------------------------------------------------------------------------
   30-   92 (49.47/ 9.34)	........SDWRTQLQP.EARHRIVNKI..METLKKHLP..VSVPEGLTEL................HKIAvrfeekiyTAATSQSD......YLRKI
   93-  157 (108.12/30.65)	SLKMLSMESQTKTQQNP.GNVQVIPNQN..PPGPAPGLPPQVSNPAQSSAI................PLIS........QQQTRQSN......ASTSV
  160-  228 (71.93/17.50)	SLPSLGQNSSSVSQASTlHNMSVMP.QNtmNNGLAQG.TPQDMYAAQRQMA................GR..........QQQQQQQQahnqliYQQQ.
  675-  723 (66.12/15.39)	Q.......TSQGLQQHD.SHTSQMPQAS..LPSMNTGVQTSGAPAPQGTNF................GV............PTTQQN...........
  825-  887 (54.45/11.15)	.............QQ....KQTLQPQLP..IQQLKKQQQQGQMQFPQLHSGndvnelkvrqgaaiksGMY..........QQLSQRN......YYQQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.01|      19|      20|     256|     274|       4
---------------------------------------------------------------------------
  255-  273 (34.76/11.18)	TQMQSSQQPMMQMSSGLQP
  274-  292 (26.26/ 6.13)	GQTAIPQTQSMTMHSATQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.80|      38|      43|     913|     951|       5
---------------------------------------------------------------------------
  913-  951 (64.09/28.68)	PQVDQHSLLQSQVKT.GTPLHSANS..PF.VPSPSpPVAPSPM
  958-  989 (45.43/15.52)	PL....SNLSSVTSA.GQAGHQQTSlaPQ.TQS....IAVN.T
  990- 1026 (47.27/16.46)	PGISASPLLAEFTSAdGSP...ANV..PTqVPAKS.SAAERPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.45|      13|      15|     447|     459|       6
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  447-  459 (24.39/ 7.84)	QQQKVIQQPQQQQ
  463-  475 (23.06/ 6.86)	QTSMGLIQPQSQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     217.50|      38|     422|     363|     400|       7
---------------------------------------------------------------------------
  363-  400 (65.03/27.01)	NQLMNQQSGVVETQQ.QQRLPVQ..SNNLLNMQQTQQMMNQ
  529-  559 (42.74/14.75)	RGLQEAPSTSVDSTA.QTGHP.........GIGDLQEELYQ
  573-  611 (41.07/13.83)	NELYNKVS..IKIQQiDNQMPAQksAEQYEKMKGFKGMLER
  636-  659 (30.21/ 7.85)	RQILSILS......S.QRRKPVQ..APG....QQTFQ....
  803-  823 (38.46/12.39)	RQ....EHQMMQSQQ................MKQRQQMMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.03|      27|      43|    1048|    1074|       8
---------------------------------------------------------------------------
 1048- 1074 (45.51/23.99)	GSVVS.MIDRIAGSAPGNGSRA.AVGEDL
 1092- 1120 (34.52/16.62)	GSGASkKMKRDTSAMPLNVSSAgSVNDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.36|       9|      56|     235|     252|       9
---------------------------------------------------------------------------
  235-  248 (12.12/ 6.81)	LQQNslmpsHIQQQ
  514-  522 (16.24/ 7.17)	LQQN.....NIDQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.90|      23|      31|     728|     750|      10
---------------------------------------------------------------------------
  728-  750 (41.48/19.92)	PQAGSNLENAQGNNFNHVQHGSM
  761-  782 (36.15/16.27)	PMQGA.LNAQQQSSSNMISNNAM
  785-  801 (21.28/ 6.10)	MQ..TN.NNANANSLQQLKQ...
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10024 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKI
2) PISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPG
3) PLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKARTTQRE
4) QKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQ
5) RKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQ
6) SQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKS
1
894
996
233
90
644
48
991
1038
507
228
872










Molecular Recognition Features






MoRF SequenceStartStop




NANANA