<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10023

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKIMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQKYLNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQTSAGMLLQQNNIDQKQYVQAQRGLQEAPSTSVDSTAQTGHPGIGDLQEELYQMIKSLKDQYFVELNELYNKVSIKIQQIDNQMPAQKSAEQYEKMKGFKGMLERTLHFLQVNKSNIHPGLREKIPIYERQILSILSSQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKSGMYQQLSQRNYYQQIKQGGVFPISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPGISASPLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTTQRESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKKMKRDTSAMPLNVSSAGSVNDSLKQSYGVGTPELQSTATSRVKWQRAEVNHALMEEIQEINQQLIDTELHVSEDDAESFTTSEGGKGTVIRCTFTAVAVCPSLKSVFASAQMSPILPLRLLVPASYPKCSPVLLDKFPDEQCRNSDDLSTKAKTKFSVLLRGLAEPMSLREIARTWDACARKVITEYAQQTGGGSFSSSYGCWESCVGAC
Length1294
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.766
Instability index70.10
Isoelectric point9.33
Molecular weight142243.68
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10023
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     516.73|      57|      57|     345|     401|       2
---------------------------------------------------------------------------
  160-  213 (57.30/13.58)	NSSSVSQAsTLHN.MSVMP.QNT..MNN.......G..LAQGTPQDMYA.AQRQMAG...RQQQQ...QQ....QQA........H
  214-  259 (57.98/13.85)	NQLIYQQQ.KYLNQK..LQ.QNS..LMPS....H.......IQQQQ..P......LLqstQMQSS...QQ....PMM........Q
  343-  393 (86.68/25.41)	......QP.QLMNQQSNLQ.QNQ..LMNQ....QSG..VVETQQQQRLP.VQSNNLL...NMQQT...QQ....MMN........Q
  394-  449 (68.25/17.99)	QSMSLHQP.QQLANQGNMSsQNQ.....Q....QQQ..LLGTGPNARMHmLQQQKVI...QQPQQ...QQ....HAQ........Q
  450-  501 (54.27/12.36)	TSMGLIQP.Q..SQQNQLQ.QPQqhMMSQ...fQSQ....PNQMQQQLG............MQQR...LQtsagMLL........Q
  502-  545 (43.56/ 8.05)	QN.NIDQK.QYVQAQRGLQ.EA...........PST..SVDSTAQTGHP...........GIGDL...QE....ELY........Q
  767-  809 (54.77/12.56)	.AMSTMQT.N.....NNAN.ANS..L..Q....Q.....LKQQRQEHQM.MQSQQ......MKQR...QQ....MMQ........Q
  812-  884 (40.00/ 6.61)	QKQTL.QP.QLPIQQLKKQ.QQQ..GQMQfpqlHSGndVNELKVRQGAA.IKSGMYQ...QLSQRnyyQQ....IKQggvfpissP
  885-  934 (53.92/12.22)	QTLQTSSP.QISHHSPQVD.QHS..LLQS....Q.....VKTG....TP.LHSANSP...FVPSP...SP....PVA........P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.58|      69|     318|     617|     693|       4
---------------------------------------------------------------------------
  649-  759 (85.14/30.35)	GQAPSSNISQQLQTSQ..GLQQHdSHTSQMPQASLPSMNTGVQTSGApapqgtnfgvpttqqnvtnAPqagsnlenaqgnnfnhvqhgsMGAALQQERTGPMQgALNAQ..QQSS
  941- 1007 (87.13/28.18)	SDKPLSNLSS..VTSA..GQAGH.QQTSLAPQTQ....SIAVNTPGI.................saSP.....................LLAEFTSADGSPAN.VPTQVpaKSSA
 1008- 1049 (39.32/ 6.74)	AERPLDRLLKALRTTQreSLS...AAVSDI..GSVVSMIDRI..AGS...................AP...............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.51|      23|      41|      85|     113|       6
---------------------------------------------------------------------------
   85-  113 (30.45/23.56)	QSDYLrkislKMLSmESQTKTQQNPGNVQ
  129-  151 (36.06/14.08)	QSSAI.....PLIS.QQQTRQSNASTSVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.18|      23|      27|     586|     612|       7
---------------------------------------------------------------------------
  586-  612 (37.18/33.57)	EKMkgfkGMLER.TLHFL..QVNKSNIHPG
  615-  640 (32.00/18.51)	EKI....PIYERqILSILssQRRKPVQAPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10023 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQ
2) MDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKI
3) PISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTP
4) PLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTT
5) QKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQ
6) SQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKS
92
1
880
982
226
630
221
48
976
1022
493
858










Molecular Recognition Features






MoRF SequenceStartStop




NANANA