<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10021

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPGTGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQKYLNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQTSAGMLLQQNNIDQKQYVQAQRGLQEAPSTSVDSTAQTGHPGIGDLQEELYQMIKSLKDQYFVELNELYNKVSIKIQQIDNQMPAQKSAEQYEKMKGFKGMLERTLHFLQVNKSNIHPGLREKIPIYERQILSILSSQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKSGMYQQLSQRNYYQQIKQGGVFPISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPGISASPLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKAVSNLPPCLLFF
Length995
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.901
Instability index75.34
Isoelectric point9.74
Molecular weight110394.22
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10021
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.17|      24|      24|     264|     287|       1
---------------------------------------------------------------------------
  264-  287 (45.04/10.72)	QPTQ..SVVRQ.QQHPQSMHQQSSLQQ
  289-  314 (38.28/ 7.67)	QPTQqpNIPLQ.QQQPQLMNQQSNLQQ
  432-  456 (37.84/ 7.47)	QPQQ..HMMSQfQSQPNQMQQQLGMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     429.76|      77|      77|     721|     797|       3
---------------------------------------------------------------------------
  152-  202 (52.50/ 7.40)	MYAA...QrQMAGRQ..Q..QQ.......................QQQQahnqliyQQ.QKYLN.............QKLQQNS..LMPSHIQ.QQQP
  512-  589 (66.92/12.40)	MIKSlkdQ.YFVELN..ELYNKVSIKiQQIDN.Q...MPAQ..KSAEQY.......EKmKGFKGML.ERTLHFLQVNKSNIHPG..LRE.KIPIYERQ
  590-  638 (59.70/ 9.90)	IL.S..................ILSS.QRRKPvQ...APGQQ.TFQQSS.......GQ.APSSNI.....SQQLQT.....S.....QGL.QQHDSH.
  639-  700 (54.36/ 8.04)	...T...S.QMPQASlpSMNTGVQTS.GAPAP.QgtnFGVPTTQQNVTN.......AP.QAGSN.........L...ENAQGNN..FNHVQ.....HG
  701-  759 (89.24/20.15)	SMGA.................ALQQE.RT...........GPMQGALNA.......QQ.QSSSNMISNNAMSTMQTNNNANANS..LQQLKQQRQEHQ
  760-  836 (107.04/26.32)	MMQS...Q.QMKQRQ..QMMQQIQQK.QTLQP.Q...LPIQQLKKQQQQ.......GQ.MQFPQLHSGNDVNELKVRQGAAIKSgmYQQL.SQRNYY.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.85|      38|      78|     315|     352|       4
---------------------------------------------------------------------------
  104-  132 (36.69/ 6.38)	NA...........STSVQGSLPSL.GQNSSSVSQASTLHNM
  315-  352 (66.36/19.40)	NQLMN..QQSGVVETQQQQRLPVQ.SNNLLNMQQTQQMMNQ
  392-  429 (48.80/11.69)	NARMHmlQQQKVIQQPQQQQHAQQtSMGLIQ.PQSQQ..NQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.22|      15|      36|     846|     860|       5
---------------------------------------------------------------------------
  846-  860 (26.02/12.17)	PISSPQTLQTSSPQI
  871-  884 (19.35/ 6.69)	SLLQSQ.VKTGTPLH
  885-  898 (20.85/ 7.91)	SANSP.FVPSPSPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.18|      14|      31|     205|     218|       6
---------------------------------------------------------------------------
  205-  218 (25.70/ 9.59)	QSTQMQSSQQPMMQ
  234-  247 (21.48/ 6.15)	QSMTMHSATQSGIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.72|      24|      33|     918|     942|       9
---------------------------------------------------------------------------
  918-  942 (36.88/19.92)	TSAGQAGHQQTSLAPQTQSiAVNTP
  954-  977 (40.84/18.57)	TSADGSPANVPTQVPAKSS.AAERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.49|      10|     165|      93|     102|      10
---------------------------------------------------------------------------
   93-  102 (19.02/ 8.81)	PLISQQQTRQ
  250-  259 (18.46/ 8.26)	PLNSVQQSVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10021 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTP
2) PLLAEFTSADGSPANVPTQVPAKSSAAERPLDR
3) QKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQ
4) RKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPGTGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQ
5) SQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKS
846
948
185
42
596
942
980
459
180
824










Molecular Recognition Features






MoRF SequenceStartStop




NANANA