<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10008

Description Polymerase II transcription-mediator2
SequenceMHRYSSNSAGFSGGRDGARLEASPFSSSSSGYPVSSSGDSDIFFSLTPLSFRRQQQLVPYKLKCDKDPLNNKLGPPDFYPQTPNCPEETLTKEYAQAGYKETVEGIEEAREIVLSQIPYFCKPDAVIKCKEALKKRLRAINESRAQKRKAGQVYGVPLSGSLLIKPGVYPEQRPCNEDARRKWIEALAQPNKRLRSLSEHVPHGYRRKSLFEGLIRYNVPLLRATWFIKVTYLNQLQTRQTPNSISVAGSDNQRSNQWTKDVVEYLQHILDEFCSKEGAFVHPSFREQSSPGPTAGTNQIKMKTEASPAAGDIEEPLVHFKWRYMVRLIQWHLTEELLVPSVLIEWLSNQLQERDSVDVLELLLPIMLGLVDTITLSQTYVRMFVELLVRRLNDASVVDSPKGPSVSSVIAELLRYMVLAVPDTFISLDCFPLPSFVVPDVYGRGALLKITSSGGISSSKRCDAYRYLSCGYAVCSIQKRAYDLATVANPNLQARGAAKVVQALDIALVTGNLSVAYSSLFNDLSDTLMEERWIKEVSPSLQSSLMWIGTVELSLICSIFFLCEWATCDYRDCRASPSRNVKFTGRRDLSQIHMAVSILKNKMDEMNNLSRSKSSTRVTLNNITKGSSLTDACLTAAAVDDTSGLQSNAKNVDEKKDTNDIFESPGPLHDIIVCWLDQHEVSSVAGFTRVDVLIVELIRNGIFFPQAYVRQLIISGITDKNDTMLDVERKRRHHRTLKQLPGSSLFDILEETRTVEEQQLYEMMSTYSSERRLVLSELSCDHSFYASGRGEYTASSCIRKQSDLPLASGGDKHGRVPEQVEDVKALLSSLLGFTYPSPVESEPRQIKTSFQESATSTLSQVETGEAKSGCEVCMRSKGQKLDDTATPFQGFSLIQSDEEDIWWVRKGTKLQESFNIEPVQKSVKQTSRGRAKVVRKTQSLAQLAAARIEGSQGTSTSHVCESKMSCPHHKPNIDGDNVKDFDHTRVANLTEIGKSLKRLRLLERRSVSSWLLKTVRQLIEGNETTAAKATNSISILSLQSDDKTTSKWRLGDEELLSVLYLLDTCCDLVSCARFLVWLLAKIRGGMGSSGQPGRSSMHTRNRDHQVCQVSEALVFSSLLRYENILLAADILPDVLSALVNRNSVSAIVRHPGSTAFAYVRYFLKKYRDVAGVAKWEKSFRTTCDQRLLAELDNGRSIDGELISSSGVSAGEEIDEQVRQKLNGRSSRLVQNMKEIVQRQADEIQRSLKEKKVLATPRNPPTFEKEDSYQIAHDIVSGLVECIRQNGGANPDGDLSTVASAVSAIVANAGHVIAKHLDFAGGNYQGVNSVSNSLNFVRHTLRVHINSLCLLKETLGDRFSRAFEIALAVETSGAVTAAFASPKMHRNQFQPSPEAHDAYGNHTSDLSNSGKGFVGRTAKVSAAVSALVVGAVVHGAVSLERMVAALKIKDGLDILQLLRGLKSSSNGVSRPTGTFRIEHSTDVLVHWFRVLLGNCRTVYDGLIADILGDSYILALSRLQQMLPLSVIFPPAYSIFAMVLWRRYIFNREDPQLYQSLSNAISDITRHQPFREICFRNTHRLYNLLASDVGDSEFAAMLETHSPDRNSKILPFIPLRARLFLDALIDCNTPTIQGDGASEPCDPKDNELKLSERLMQLLDTLQPAKFHWQWVEMRLLLDEQALMEKVAAGKTALESLRSLSPKAEGFTLSDSEKGFTEVILSRLLARPDAAPLYSEAVRLLGKLQESLVMDVKWILQGQDAILGRRSTRQQLVHIAQRKGLSTKAQVWKPWGWSSLLSDVIPNKTAKRKLEVTSIEEGEVVDDTVDAKRPSKTPPHSVDRSFEAIRSINKYLTEKALAELVLPCIDRSSADIRGILSVDLIKQMGTISEHIKAIARNGAKQAGSVPSGNEVPSSKSSGRKGIRGGSPNIGRRAPVGNDPSPPSASALRAALWLRLQFIIRLLPVIMADRSMRQTLASAILGLLATRMIYEDADLPLPPTNATALRREVDSLLEPPLDVLLDRPGESLFERLLCVLHALLGSYKPSWLKSRSASRSTIRIQRDFSAFDNEAAEGLQSALDHMELPETIRRRIQAAMPLLPPSRHPSLQCQPPQLSLAALTPLQSSTSGVGPQQKSCSASWVPTNVSGRSKAALPSHDPEMEVDPWNLLEDGTSCPSTASGSHGASGVTGDHANLKACSWLKGAVRVRRTELTYIGSLDDDT
Length2217
PositionKinase
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.06
Grand average of hydropathy-0.274
Instability index51.49
Isoelectric point8.56
Molecular weight245338.81
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10008
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.19|      27|      50|    2097|    2124|       1
---------------------------------------------------------------------------
 2097- 2124 (46.08/31.37)	PSRHPSLQCQPPQLsLAALTPLQSSTSG
 2150- 2176 (53.11/32.13)	PSHDPEMEVDPWNL.LEDGTSCPSTASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.53|      25|      49|     361|     408|       2
---------------------------------------------------------------------------
  361-  385 (43.25/58.81)	ELLLPIMLGLVDT.ITLSQTYVRMFV
  412-  437 (41.28/14.14)	ELLRYMVLAVPDTfISLDCFPLPSFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     261.88|      89|     372|    1069|    1165|       5
---------------------------------------------------------------------------
 1069- 1165 (139.59/106.57)	VSCARFLVWLLAK........IRGGMGSSGQPGRSSMHTRNrDHQvcqvSEALV..FSSLL...R..YENilLAADILPD....VLSALVNRNSVSaIVRHPGSTAFAYV...RYFLKK
 1436- 1546 (122.29/72.90)	VSLERMVAALKIKdgldilqlLRGLKSSSNGVSRPTGTFRI.EHS....TDVLVhwFRVLLgncRtvYDG..LIADILGDsyilALSRLQQMLPLS.VIFPPAYSIFAMVlwrRYIFNR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10008 with Med12 domain of Kingdom Viridiplantae
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