<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09870

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLLQQNNIDQQKQYVQAQKVLQEAPSTSVDSTAQTGHPGTGDSQEELYQMIKSLKDQYFAELNDVYNKISMKIQNIDNHMPAQKSAEQYERLKGFKGMLERILHFLQANKSSIQPGFREKISIFERQILSIMSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQKKILQQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMYQPLNQRNYYQQIKRGDVFPISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSIAVNTPGISASPLLAEFTSADGGQVSVPTQVPTKSSAAERPLDRLLKAVSNLPPSCLLSFDN
Length993
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.867
Instability index72.14
Isoelectric point9.74
Molecular weight109884.80
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09870
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     413.85|      54|      56|     249|     302|       2
---------------------------------------------------------------------------
  149-  187 (50.57/ 8.01)	QRQMAGRQQQQQ....QQQAHNQF...................MYQQQK.L..............LMNQ.KLQ.QNSRM
  188-  240 (56.13/10.02)	QPHIQQ..QQTLLQSTQMQSSQQP...................MVQMSSgLQPGQiaiP.QTQSMAMQS.ATQ.S..GI
  249-  302 (102.40/26.73)	QQPVQSLLQQPTPSVVRQQQHPQS...................MHQQSS.LQQTQ...PTQQPNIPLQQ.QPQ.QLMGH
  307-  344 (46.40/ 6.50)	QQ..NQL........VNQQSGAVE...................MQQ.....QQRL...PVQSTNLLNMH.QTQ.QMM..
  386-  441 (50.43/ 7.95)	QQ..QKPIQQP.....QQQQHAQQtsmglmqpqsqqnqlqqpqQHMMSQ.F.QSQ...PNQ.....TQQ.Q.....LGM
  591-  638 (56.93/10.31)	QAPGQQTFQQ......SGGQAPSS..................nMSQQH...QTSQ...GLQQHDSHTNQ.MPQaSLPSM
  754-  792 (50.99/ 8.16)	HQMMQN..QQ....MKQRQQMLQQ...................MQQKKI.LQQ..........QLPIQQlQKQ.Q...Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     159.01|      32|      33|     684|     716|       4
---------------------------------------------------------------------------
  684-  714 (54.13/22.46)	.QGNNFNPVQHGSMGTALQQGSTGPMQGALNA
  716-  744 (42.33/17.36)	HQSNS.NMISNNAMST..MQTNTNAMQANVNS
  802-  826 (29.34/ 6.22)	HSGNDVNELK.VRQGAAIKSGMYQP....L..
  827-  849 (33.21/ 8.41)	NQRNYYQQIKRGDV.........FPISSPQNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.53|      24|      33|      53|      78|       5
---------------------------------------------------------------------------
   53-   78 (37.18/15.63)	SQKKTQQnPgNAQVIPNQNPPGPGSN
   89-  112 (42.35/11.98)	SQQQTRQ.P.NASTSVQGSLPSVGQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.98|      32|      43|     866|     897|       6
---------------------------------------------------------------------------
  866-  887 (30.72/10.39)	.....................SLLQSQVKTGTPLHS..ANSPFVP
  888-  927 (44.71/18.80)	SPSPPVAPSP..vpldsdkplSNLSSLTSAGQAGHQ..QTS.LAP
  934-  973 (26.54/ 7.88)	VNTPGISASPllaeftsadggQV...SVPTQVPTKSsaAERPL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.96|      19|      39|     487|     505|       7
---------------------------------------------------------------------------
  487-  505 (29.71/14.23)	HPGTGDSQEELYQMIKSLK
  509-  527 (23.60/ 9.57)	FAELNDVYNKISMKIQNID
  528-  546 (26.64/11.88)	NHMPAQKSAEQYERLKGFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.41|      22|      96|     346|     378|       8
---------------------------------------------------------------------------
  122-  143 (40.24/ 9.79)	LQNLS.GMPQNTMNNG....LAQGTPQ
  346-  372 (31.17/24.11)	QQSMPlHQPQQLANQGnvssLNQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.89|      13|      25|     548|     560|       9
---------------------------------------------------------------------------
  548-  560 (23.19/19.81)	MLER.ILHFL..QANK
  573-  588 (13.70/ 8.09)	IFERqILSIMssQRRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.84|      14|      16|     442|     455|      11
---------------------------------------------------------------------------
  442-  455 (23.50/ 9.71)	QQRLQTSAGMLLQQ
  460-  473 (23.34/ 9.60)	QQKQYVQAQKVLQE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09870 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQK
2) PISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSI
3) QQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMY
4) RKISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLL
582
842
779
42
775
932
823
453










Molecular Recognition Features






MoRF SequenceStartStop




1) RPLDRLLK
971
978