<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09869

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLLQQNNIDQQKQYVQAQKVLQEAPSTSVDSTAQTGHPGTGDSQEELYQMIKSLKDQYFAELNDVYNKISMKIQNIDNHMPAQKSAEQYERLKGFKGMLERILHFLQANKSSIQPGFREKISIFERQILSIMSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQKKILQQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMYQPLNQRNYYQQIKRGDVFPISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSIAVNTPGISASPLLAEFTSADGGQVSVPTQVPTKSSAAERPLDRLLKAVYFLLTISCLINSVWNMVLNVINMLINLHNILS
Length844
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.809
Instability index73.02
Isoelectric point9.72
Molecular weight93847.33
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09869
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.22|      39|      39|      81|     119|       2
---------------------------------------------------------------------------
   71-  115 (65.42/13.72)	GIQQnalnsvQQPVQSLLQQ...PTPS..VVRQQQHPQSMHQQS.SLQQTQ
  143-  187 (43.29/ 6.28)	LVNQ......QSGAVEMQQQqrlPVQStnLLNMHQTQQMMNQQSmPLHQPQ
  421-  461 (47.56/ 7.72)	PVQA....pgQQTFQQSGGQ..aPSSN..MSQQHQTSQGLQQHD.S.HTNQ
  579-  614 (44.95/ 6.84)	QLKQ......HQEHQMMQNQ......Q..MKQRQQMLQQMQQKK.ILQQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.72|      17|      25|     463|     486|       3
---------------------------------------------------------------------------
  259-  275 (28.12/ 6.36)	QFQSQPN.....QTQQQLGMQQ
  463-  484 (26.60/ 9.56)	PQASLPSmntgvPTSGAPGIQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     176.30|      33|      86|     685|     717|       5
---------------------------------------------------------------------------
  655-  686 (22.50/ 7.93)	......YQPLNQRNYYQ.QIKRGDvfPISSpqnlqASSP.
  687-  717 (50.30/28.98)	..QISHYSHVDQHSLLQSQVKTGT..PLHS.....ANSPF
  722-  745 (35.14/17.50)	SPPVAP.SPVPLDS........DK..PLSN.....LSSLT
  747-  775 (40.60/21.64)	AGQAGH.QQTSLAPLTQS.IAVNT..PGIS.....A.SP.
  777-  805 (27.76/11.91)	...LAEFTSADGG...QVSVPTQV..PTKS...saAERPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.76|      21|      86|     118|     142|       6
---------------------------------------------------------------------------
    3-   25 (28.07/ 7.88)	QQQKLLMNQ.KLQQNS......rMQPHiQQ
  201-  230 (19.68/ 6.31)	QQQQLLGTVpNVRMHMlqqqkpiQQPQqQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     197.99|      42|      92|     522|     563|       8
---------------------------------------------------------------------------
  280-  314 (37.67/15.30)	.....SAGMLLQQNNIDQQKQYVQAQKVLQEAP.ST.......SVDST.
  316-  362 (51.10/23.74)	..QTGHPGTGDSQEELYQMIKSLKDQYFAELNDVYNkismkiqNIDNHM
  363-  395 (37.23/15.03)	PAQKSAEQYERLKGFKGMLERILHFL.QANKSSI...............
  522-  563 (71.99/36.85)	PVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISN.......NAMSTM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09869 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLL
2) MSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQK
3) PISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGH
4) QQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMY
7
414
674
611
285
607
752
655










Molecular Recognition Features






MoRF SequenceStartStop




NANANA