<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09868

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLLQQNNIDQQKQYVQAQKVLQEAPSTSVDSTAQTGHPGTGDSQEELYQMIKSLKDQYFAELNDVYNKISMKIQNIDNHMPAQKSAEQYERLKGFKGMLERILHFLQANKSSIQPGFREKISIFERQILSIMSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQKKILQQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMYQPLNQRNYYQQIKRGDVFPISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSIAVNTPGISASPLLAEFTSADGGQVSVPTQVPTKSSAAERPLDRLLKALRTTQPESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKRMKRDTGAMPLNVSSAGSLNDSLKQSYTVGTPELQSTATSRVKCQRAEVNHVLLEEIQEINKQLIDTELHVSEDDAESFTTSDMAEGTVIKCTFTAVAVSPSLKSMFASAQMSPILPLRLLVPGSYPKCSPVLLDKFPDEQCRNSDDLSTKAKSKFSVLLRGLAEPMSLREIARTWDACARKVIAEYAQQTGGGSFSSSYGCWESCVGAS
Length1255
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.734
Instability index67.57
Isoelectric point9.32
Molecular weight137873.20
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09868
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     601.41|      62|      64|     184|     245|       2
---------------------------------------------------------------------------
   69-  115 (49.12/ 8.19)	.NQNPP.G.PG....S.N...PA.QSSAI...........PLMSQQQ..TR.QP.N...............A............STSVQG....SLPS............VG.....QN.................lsS
  116-  190 (69.31/15.29)	VSQTLT.L.QN....L.S...GM.................PQNTMNN..GL.AQ.G.....tpqdmyaaqrQM..AG...RQQQQQQQQA....HNQF...........MYQ.....QQ.KLlmnqklqqNSRMQP..H
  191-  251 (100.87/26.38)	IQQQQT.L.LQ....S.T...QM.QSSQQ...........PMVQMSS..GL.QP.G...............QI..AI...PQTQSMAMQS....ATQS...........GIQ.....QN.AL........NSVQQP...
  252-  320 (63.13/13.11)	V...QS.L.LQqptpSvV...RQ.QQHPQ...........SMHQQSSlqQT.QPtQ...............QP..NI...PLQQQPQQLM....GHQS...........NLQ.....QN.QL.....vnqQSG.AV..E
  321-  383 (70.00/15.53)	MQQQQR.LpVQ....S.TnllNM.HQTQQ...........MMNQQSM..PLhQP.Q...............QL..A....NQGN...VSS....LNQQ.............Q.....QQ.LL....gtvpNVRM....H
  384-  447 (68.07/14.85)	MLQQQK.P.IQ....Q.P...QQ.QQHAQ..............QTSM..G......lmqpqsqqnqlqqpqQH..MM...SQFQSQPNQT....QQQL...........G...........M........QQRLQT...
  582-  665 (59.95/11.99)	MSSQRRkP.VQ....A.P...GQ.QTFQQsggqapssnmsQQHQTSQ..GL.Q..................QH..D....SHTNQMP.QA....SLPSmntgvptsgapGIQhvpapQA.S.........NFG.VP..T
  666-  734 (58.24/11.39)	TQQNVT...........N...AP.QAASN...........PENAQGN..NF.NP.V...............QHgsMGtalQQGSTGPMQGalnaQHQS........nsnMIS.....NN.AM.........STMQT..N
  735-  789 (62.73/12.97)	TNAMQA.N.VN....S.L...QQlKQHQE.............HQM.M.....QN.Q...............Q....M...KQRQQMLQQM....QQKK...........ILQ.....QQlPI........Q.QLQK...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.94|      19|      57|     866|     884|       3
---------------------------------------------------------------------------
  866-  884 (36.28/17.87)	SLLQSQVKTGTPLHSANS..P
  907-  927 (21.56/ 7.18)	SNLSSLTSAGQAGHQQTSlaP
  928-  943 (21.09/ 6.84)	.LTQS.IAVNTPGISA.S..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      18|      23|     532|     553|       4
---------------------------------------------------------------------------
  532-  553 (26.91/27.29)	AQKSAEQyerlKGFK...GMLER.IL
  558-  579 (23.68/13.11)	ANKSSIQ....PGFRekiSIFERqIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.86|      22|     227|     944|     988|       6
---------------------------------------------------------------------------
  944-  969 (30.67/53.39)	LLAEFtsadGGQVS....VPTQVPTKSSAA
  991- 1016 (30.19/ 6.26)	AVSDI....GSVVSmidrIAGSAPGNGSRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.46|      15|     276|     885|     901|       7
---------------------------------------------------------------------------
  885-  901 (26.24/21.14)	FVPSPSPPVapSPVPLD
 1166- 1180 (30.22/16.97)	LVPGSYPKC..SPVLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.91|      35|     227|     825|     862|      10
---------------------------------------------------------------------------
  453-  490 (49.06/17.14)	LQQNNIDQQkqyVQAQKVLQ.EAPSTSVDSTAQTGHPGT
  826-  861 (58.85/35.06)	LNQRNYYQQ...IKRGDVFPiSSPQNLQASSPQISHYSH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09868 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQK
2) PISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSI
3) QQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMY
4) RKISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLL
5) SADGGQVSVPTQVPTKSSAAERPLDRLLKALRTT
582
842
779
42
950
775
932
823
453
983










Molecular Recognition Features






MoRF SequenceStartStop




NANANA