<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09867

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDGAANWRPTQGADPATVAAVGGVDPNAAAPTGSDWRTQLQPEARQRIVNKIMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLLQQNNIDQQKQYVQAQKVLQEAPSTSVDSTAQTGHPGTGDSQEELYQMIKSLKDQYFAELNDVYNKISMKIQNIDNHMPAQKSAEQYERLKGFKGMLERILHFLQANKSSIQPGFREKISIFERQILSIMSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQKKILQQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMYQPLNQRNYYQQIKRGDVFPISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSIAVNTPGISASPLLAEFTSADGGQLRTTQPESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKRMKRDTGAMPLNVSSAGSLNDSLKQSYTVGTPELQSTATSRVKCQRAEVNHVLLEEIQEINKQLIDTELHVSEDDAESFTTSDMAEGTVIKCTFTAVAVSPSLKSMFASAQMSPILPLRLLVPGSYPKCSPVLLDKFPDEQCRNSDDLSTKAKSKFSVLLRGLAEPMSLREIARTWDACARKVIAEYAQQTGGGSFSSSYGCWESCVGAS
Length1283
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.736
Instability index66.66
Isoelectric point9.25
Molecular weight140737.19
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09867
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     240.13|      43|      43|     335|     377|       2
---------------------------------------------------------------------------
  203-  244 (46.83/ 9.56)	QMAGRQQQQQQQQAHNQ.....FMYQQQkllmnQ.KLQQ.NSRMQPHIQ
  323-  349 (46.16/ 9.29)	QSMHQQSSLQQ.....................tQ.PTQQPNIPLQQQPQ
  350-  393 (63.43/16.08)	QLMGHQSNLQQNQLVNQQSGAVEMQQQQ....rL.PVQSTNLLNMHQTQ
  424-  453 (41.55/ 7.48)	QLLGTVPNVR...........MHMLQQQ.....K.PIQQPQ..QQQHAQ
  629-  667 (42.15/ 7.72)	QILSIMSS.QRRKPV.QAPGQQTFQQ........sGGQAPSSNMSQQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.38|      37|     100|     142|     191|       5
---------------------------------------------------------------------------
  106-  159 (53.08/25.10)	QKKTQQN...PGNAQVIPNQnppgpgsnpAQssaiplmsQQQTRQPNASTSVQGSLP
  280-  322 (50.30/11.93)	QSMAMQSatqSGIQQNALNS.........VQ.....qpvQSLLQQPTPSVVRQQQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     608.27|     157|     210|     854|    1018|       6
---------------------------------------------------------------------------
  483-  549 (61.83/14.88)	.......................QP.N...QTQ..QQL........GMQQRLQ..TSAG...MLLQQNNI......................DQQkQYVQAQ....KVLQEAPS.......................TSVDS........................TAQTGHPGTGDS..QEEL...............................................................
  670-  792 (136.40/41.17)	.................................................QGLQ..QHD......SHTNQM......................PQA.S.LPS.MNTGVPTSGAP..giqhvpapqasnfgvpttqqnVTNAPQ........................AASNPENAQGNN..FNPVQH.GSM...GTA.LQ..QGSTG.PM.QG.ALNAQHQSNSNMI....SNNAMSTMQTNTNAMQA
  854- 1018 (253.50/94.92)	HSGNDVNE.LKvRQGAAIksgmyQPLN...QRNYYQQIKRGdvFPISSPQNLQ..ASSP...QISHYSHV......................DQH.SLLQSQVKTGTPLHSANSP.....................FVPSPS........................PPVAPSPVPLDS..DKPLSNLSSLTSAGQAGHQ..QTSLA.PLTQSIAVNTPGISASPLLAEFTSADGGQLRTTQPESLSA
 1066- 1266 (156.53/49.48)	HDGSGASKrMK.RDTGAM......PLNvssAGSLNDSLKQS..YTVGTPE.LQstATSRvkcQRAEVNHVlleeiqeinkqlidtelhvsedDAE.SFTTSDMAEGTVIKCTFTA.....................VAVSPSlksmfasaqmspilplrllvpgsyPKC..SPVLLDKfpDEQCRNSDDLSTKAKSKFSvlLRGLAePMSLREIARTWDACARKVIAEYAQQTGG............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.50|      26|     211|     176|     201|       7
---------------------------------------------------------------------------
  175-  200 (46.18/19.00)	QNLSGMPQNTMNNG..................LAQGTP.QDMYAA
  394-  411 (28.05/ 7.40)	.....QMMNQQSMP..................LHQ..P.QQL.AN
  798-  842 (30.28/ 8.83)	QQLKQHQEHQMMQNqqmkqrqqmlqqmqqkkiLQQQLPiQQLQKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.87|      18|      23|     582|     603|      10
---------------------------------------------------------------------------
  582-  603 (27.56/30.94)	MPAQKSAEQyerlKGFK...GMLER
  608-  628 (27.31/17.76)	LQANKSSIQ....PGFRekiSIFER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09867 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLL
2) MDGAANWRPTQGADPATVAAVGGVDPNAAAPTGSDWRTQLQPEARQRIVNKI
3) MSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQK
4) PISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSI
5) QQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMY
96
1
634
894
831
505
52
827
984
875










Molecular Recognition Features






MoRF SequenceStartStop




NANANA