<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09865

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDGAANWRPTQGADPATVAAVGGVDPNAAAPTGSDWRTQLQPEARQRIVNKIMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLLQQNNIDQQKQYVQAQKVLQEAPSTSVDSTAQTGHPGTGDSQEELYQMIKSLKDQYFAELNDVYNKISMKIQNIDNHMPAQKSAEQYERLKGFKGMLERILHFLQANKSSIQPGFREKISIFERQILSIMSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQKKILQQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMYQPLNQRNYYQQIKRGDVFPISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSIAVNTPGISASPLLAEFTSADGGQVSVPTQVPTKSSAAERPLDRLLKALCKQHKSVSMVSSRSTS
Length1048
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.862
Instability index69.74
Isoelectric point9.84
Molecular weight115654.17
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09865
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     532.36|      62|      63|     236|     297|       2
---------------------------------------------------------------------------
   72-  148 (56.06/10.04)	H..........KIAVRFEEkiytaatsqsdylrkiSLKMLSmESQKKTQQ.......NPG........NAQVIP..NQN..PPG........PG....S.N...PAQSSAI........PLM.SQQQ..T..R.QP
  192-  271 (93.59/23.74)	GtpqdmyaaqrQMAGRQQQ................QQQQQA.HNQFMYQQ.......QKLlmnqklqqNSRMQPHIQQQ..QTL........LQ....S.T...QMQSSQQ........PMV.QMSS..G..L.QP
  272-  336 (78.32/18.16)	G..........QIAIPQTQ................SMAMQS.ATQSGIQQ.......NAL........NSVQQP.V.....QSL........LQqptpSvV...RQQQHPQ........SMH.QQSSlqQ..T.QP
  338-  406 (75.35/17.08)	Q..........QPNIPLQQ................QPQQLM.GHQSNLQQ.......NQL.....vnqQSG.AVEMQQQ..QRL.......pVQ....S.TnllNMHQTQQ........MMN.QQSM..P..LhQP
  407-  458 (64.17/13.00)	Q..........QLA.NQGN...................VSS.LNQQ..QQ.......QLL....gtvpNVRM..HMLQQ..QKP........IQ....Q.P...QQQQHAQ............QTSM..G......
  474-  524 (55.62/ 9.88)	...........QHMMSQFQ................SQPNQT.QQQLG............M........QQRLQT...SA..GML........LQ....Q.N...NID.QQK........QYV.QAQK..V..L.Q.
  766-  832 (58.73/11.02)	.............AQHQSN................SNMISN.NAMSTMQT.......N.T........NA.MQANVNSL..QQLkqhqehqmMQ....N.Q...QMKQRQQ........MLQ.QMQQ..KkiL.QQ
  833-  906 (50.53/ 8.02)	...........QLPIQQLQ................KQQQQG.PIQ..VQQlhsgndvNEL........KVRQGAAIKSGmyQPL........NQ....R.N...YYQQIKRgdvfpissPQNlQASS........P
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.14|      25|      25|     596|     620|       3
---------------------------------------------------------------------------
  575-  600 (35.78/19.43)	IQN.IDNHM..PAQKSAEQyERLKGFKGM
  601-  625 (40.39/23.09)	LER.ILHFL..QANKSSIQ.PGFREKISI
  626-  651 (19.98/ 6.91)	FERqILSIMssQRRKP.VQaPGQQTFQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.97|      24|      25|     683|     706|       4
---------------------------------------------------------------------------
  155-  178 (25.84/ 6.59)	.Q.GSLPSVGQNLSSvSQTLTLQNLS
  683-  706 (48.75/18.15)	PQ.ASLPSMNTGVPT.SGAPGIQHVP
  708-  723 (30.88/ 9.13)	PQ.AS....NFGVPT.TQ....QNVT
  726-  747 (33.50/10.45)	PQaASNPENAQG..N.NFNP.VQHGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.21|      28|      33|     957|     989|       5
---------------------------------------------------------------------------
  957-  989 (35.11/32.50)	PLsnLSSLTSA..GQAGhqQTSLAPlTQSIAVNTP
  995- 1024 (45.10/23.16)	PL..LAEFTSAdgGQVS..VPTQVP.TKSSAAERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.95|      27|     128|     525|     552|       6
---------------------------------------------------------------------------
  525-  552 (42.42/24.33)	EAPSTSVDSTAQTGHpGTGDSQEELYQM
  656-  682 (49.53/24.39)	QAPSSNMSQQHQTSQ.GLQQHDSHTNQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09865 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLL
2) MDGAANWRPTQGADPATVAAVGGVDPNAAAPTGSDWRTQLQPEARQRIVNKI
3) MSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQK
4) PISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSIA
5) QQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMY
96
1
634
894
831
505
52
827
985
875










Molecular Recognition Features






MoRF SequenceStartStop




1) RPLDRLLKALCKQHKSVSMV
1023
1042