<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09864

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDGAANWRPTQGADPATVAAVGGVDPNAAAPTGSDWRTQLQPEARQRIVNKIRMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLLQQNNIDQQKQYVQAQKVLQEAPSTSVDSTAQTGHPGTGDSQEELYQMIKSLKDQYFAELNDVYNKISMKIQNIDNHMPAQKSAEQYERLKGFKGMLERILHFLQANKSSIQPGFREKISIFERQILSIMSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQKKILQQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMYQPLNQRNYYQQIKRGDVFPISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSIAVNTPGISASPLLAEFTSADGGQVSVPTQVPTKSSAAERPLDRLLKALRTTQPESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKRMKRDTGAMPLNVSSAGSLNDSLKQSYTVGTPELQSTATSRVKCQRAEVNHVLLEEIQEINKQLIDTELHVSEDDAESFTTSDMAEGTVIKCTFTAVAVSPSLKSMFASAQMSPILPLRLLVPGSYPKCSPVLLDKFPDEQCRNSDDLSTKAKSKFSVLLRGLAEPMSLREIARTWDACARKVIAEYAQQTGGGSFSSSYGCWESCVGAS
Length1308
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.730
Instability index65.87
Isoelectric point9.36
Molecular weight143439.30
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09864
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     645.02|      62|      64|     237|     298|       2
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  119-  180 (56.64/10.28)	VI...P..NQN..P..PG.PG....S.N...PAQSSAIPLMSQQQ..T..R.QP..N...............A.......STSVQ......GSLPS...............VG................Q.......N.LssvsqtltlqNlSG
  181-  239 (59.69/11.26)	M....PQNTMN..N..GL.AQ....G.T.pqDMYAAQR...QM...............................AGRQQQQQQQQ......AHNQF...........M...YQ................Q.......QKL..lmnqklqqN.SR
  240-  301 (108.73/27.05)	MQ...PHIQQQ..Q..TL.LQ....S.T...QMQSSQQPMVQMSS..G..L.QP..G...............QIAIPQTQSMAMQ......SATQS...........G...IQ................Q.......NAL..........N.SV
  302-  370 (65.39/13.10)	QQ...P.V.....Q..SL.LQqptpSvV...RQQQHPQSMHQQSSlqQ..T.QP.tQ...............QPNIPLQQQPQQL......MGHQS...........N...LQ................Q.......NQL.......vnqQ.SG
  371-  434 (59.55/11.22)	.A...VEMQQQ..Q..RLpVQ....S.TnllNMHQTQQMMNQQSM..P..LhQP..Q...............QLA.NQGN...VS......SLNQQ................Q................Q.......QLL......gtvpN.VR
  435-  497 (62.40/12.14)	M.....HMLQQ..Q..KP.IQ....Q.P...QQQQHAQ...QTSM..G.........lmqpqsqqnqlqqpqQHMMSQFQSQPNQ......TQQQL...........G...............................M..........Q.QR
  651-  727 (56.84/10.35)	FQ.......QS..G..GQ.AP....S.S...NM..SQQ..HQTSQ..G..L.Q...................QHD.SHTNQMP.Q......ASLPSmntgvptsgapG...IQhvpapqasnfgvpttqQ.......NVT..........N.AP
  728-  798 (48.18/ 7.56)	QAasnPENAQG..NnfNP.VQ....H.G...SMGTALQ...QGST..G.....PmqG...............ALN.AQHQSNSNMisnnamSTMQT...........NtnaMQ................A.......N.V..........N.SL
  799-  866 (69.96/14.57)	QQ...LKQHQE..H..QM.MQ....N.Q...QMKQRQQMLQQMQQ..KkiL.QQ..................QLPIQQLQKQQQQ......GPIQ................VQ................QlhsgndvNEL..........K.VR
  867-  924 (57.65/10.61)	QG...AAIKSGmyQ..PL.NQ....R.N...YYQQIKRGDVFPIS.......SP..Q...............NL...QASSP..Q......ISHYS...........H...VD................Q.......HSL.........lQ.SQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.70|      55|      70|     933|     991|       3
---------------------------------------------------------------------------
  933-  991 (89.84/56.12)	SAnSP....FVPSPSPPVA.PSPVPLDS...DKPLSNL.........SSLTSagqAGHQQTSLAPLTQSIAVNTPG
  993- 1064 (72.85/35.73)	SA.SPllaeFTSADGGQVSvPTQVPTKSsaaERPLDRLlkalrttqpESLSA...AVSDIGSVVSMIDRIAGSAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.97|      21|      25|     597|     619|       4
---------------------------------------------------------------------------
  597-  618 (35.03/23.99)	GFK...GMLER.ILHFL..QANKsSIQ.P
  619-  646 (20.94/12.03)	GFRekiSIFERqILSIMssQRRK.PVQaP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.05|      56|     606|     533|     592|       5
---------------------------------------------------------------------------
  533-  592 (91.78/75.38)	DSTAQTGHPGTGDSQEELYQMIKSLKdqyfAELNDV.YNKIS.MKIQNIDNHMP.AQKSAEQY
 1119- 1177 (80.27/54.88)	DSLKQSYTVGTPELQSTATSRVKCQR....AEVNHVlLEEIQeINKQLIDTELHvSEDDAESF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09864 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KISLKMLSMESQKKTQQNPGNAQVIPNQNPPGPGSNPAQSSAIPLMSQQQTRQPNASTSVQGSLPSVGQNLSSVSQTLTLQNLSGMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQFMYQQQKLLMNQKLQQNSRMQPHIQQQQTLLQSTQMQSSQQPMVQMSSGLQPGQIAIPQTQSMAMQSATQSGIQQNALNSVQQPVQSLLQQPTPSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQPQQLMGHQSNLQQNQLVNQQSGAVEMQQQQRLPVQSTNLLNMHQTQQMMNQQSMPLHQPQQLANQGNVSSLNQQQQQLLGTVPNVRMHMLQQQKPIQQPQQQQHAQQTSMGLMQPQSQQNQLQQPQQHMMSQFQSQPNQTQQQLGMQQRLQTSAGMLL
2) MDGAANWRPTQGADPATVAAVGGVDPNAAAPTGSDWRTQLQPEARQRIVNKIR
3) MSSQRRKPVQAPGQQTFQQSGGQAPSSNMSQQHQTSQGLQQHDSHTNQMPQASLPSMNTGVPTSGAPGIQHVPAPQASNFGVPTTQQNVTNAPQAASNPENAQGNNFNPVQHGSMGTALQQGSTGPMQGALNAQHQSNSNMISNNAMSTMQTNTNAMQANVNSLQQLKQHQEHQMMQNQQMKQRQQMLQQMQQK
4) PISSPQNLQASSPQISHYSHVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPVPLDSDKPLSNLSSLTSAGQAGHQQTSLAPLTQSI
5) QQQLPIQQLQKQQQQGPIQVQQLHSGNDVNELKVRQGAAIKSGMY
6) SADGGQVSVPTQVPTKSSAAERPLDRLLKALRTT
96
1
635
895
832
1003
506
53
828
985
876
1036










Molecular Recognition Features






MoRF SequenceStartStop




NANANA