<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09845

Description Polymerase II transcription-mediator1
SequenceMPGAPLRRQQQLTPYKLKCDKDPLNNKLGPPDFYPQTLNCPEETLTKDYVQYGYKETVEGIEEAREIVISQIPYFCKPDVVIKCKEALKKRLRAINESRAQKRKAGQVYGVPLSGSLLIKPGVYPEQRPCNEDTRRKWVEALAQPNKRLRSLSEHVPHGYRRKSLFEGLIRYNVPLLRATWFIKVTYLNQARPAPNSTSVVASDNQRSNQWTKDVVEYLQQILDEVCSKEGAIVPPSFKEQSSPGLAAGTNQIKMKTESSPAGDSEEPLVHFKWRYMVRLIQWHLTEELLVPSVLIEWLSNQLQERDSDDVLELLLPIILGLVDTITLSQTYVRMFVELLVRRLNVDRPKRFSVSSVIAELLRYMVLAVPDTFVSLDCFPFPSFVVPDVYGRGALLKITSGGGILCSKRRDAYRYLSCGYAVSSIQKRAHDLAAVANPSLQARGAAKVVQALDKALVTGNLSVAYFSLFNDLSDALMEERWIKEVNPCLQSSLMWIGTVELSLICSIFFLCEWATCDYRDCRASPSQNVKFTGRRDLSQIHMAVSILKNKMDEMNNLSRPKSSTRITLNKVAKGSLNDACLTAAAVDDSSGLRSNAKNVDEKKDTNDIFESPGPLHDIIVCWLDQHEVSNVAGFTRVDVLIAELIRNGIFFPQVYVRQLIISGITDKNDTMLDVERKRRHHRTLKQLPGSSLFDVLEETRTAEEQQLYEMMSTYSSERRLVLSELSCGHSFYASGRGEYTSSSCIRKQSDLPVASEGDKHGRVLEQVEDVKALLSSLLGFTYPPLVESKLCEIKTSFQESVTSTLTQVETGEAKSGCEDCMRSKGQKLDDSATPFQGFPLIQSGEEDIWWVKKGTKLQESFNVEPVQKSVKQTSRGRAKVVRKTQSLAQLAAARIEGSQGASTSHVCESKMSCPHHEPNNDGDNVKDFDHTRAANVTAIGKSLKRLRLLERRSVSSWLLKSIRQLVDGNGMTASKATNSISILPLQPDDKTASKWRLGDEELLSVLYVLDTCCDSVSGVKFLIWLLVKIRGVGSSGQPGRTYMLMRNRDHQVCQVNEALVFSSLLRYENILLATDILPDVLSALVNRNSMSATTRHPGSTAFAYVRYFLKKYRDVASVAKWEKNFRTTCDQRLLAELDNGRSIDGDLVSSSGILAGEEIDEQVRQKLNGRSSRLVQNMKEIVQRQADGIQRSLKEKKVLAGAAPRNPLTFEKEDSYQIAHDIVLGLVECIRQNGGANPDGDLSIVASAVSAIVVNAGHMIAKHLDFAGGNYQGVNSVATSLNFVRHTLLIHINSLCLLKETLGDRFSRAFEIALAVETSAAVTAAFAPPKMHRNQFQPSPEAHDAYGNHTSELSNSGKGFVGRTAKVSAAISALVVGAVVHGAVSLERMVATLKIKDGLDIMQLLRGLKSNTNGVSHPTGGFRIENSTEVSVHWFRILLGNCRTVYDGLIADILGDPYIIALSRLQRMLPLTVIFPPAYSIFAMVLWRRYIFNCEDPQLYQSFSNAINDITRHQPFREIYFRNTHRLYNLLASDVGDSKFAAMLESHSPDRNSKILPFIPLRARLFLDAIIDCNTPTIQGDGASEPCDPKDNELKLSERLMQLLDTLQPAKFHWQWVEMRLLLDEQALMEKVAAGKTTLESLRSLSPKAEGFALSDSEKGFTEVILSRLLARPDAAPLYSELVHLLGKLQESLVMDVKWILQGQDAILGRRSTRQQLVHIAQRKGLSTKAQVWKPWGWSSLLSDAIPNKTAKRKLEVTSIEEGEVVDDTVDAKRTTKTPPHSVDRSFEGIRSINKYLTEKALAELVLPCIDRSSADIRGILSVDLTKQMGAISEHIKAIALNGAKQAGSVSSGNEVPSNKSSGRRGIRGGSPNIGRRAPVGNDPSPPSASALRAALWLRLQFIIRLLPVIMADRSMRHTLASAILGLLATRMIYEDADLPLPPTNATALRRDVDSLLEPPLDVLLDRPGESLFEKLLCVLHALLGSYKPSWLKSRSASRSSIKSQRDFSAFDNEAAEGLQSALDHMELPETIRRRIQAAMPLLPPSRRPCMQCQPPQLSLAALSPLQSSTSGVGPQQKSSCVSWVPTNVSVRSKAALPSHDPETEVDPWSLLEDGTNCPPSTASGSNGSSGVTGDHANLKASSWLKGAVRVRRTELTYIGSVDDDS
Length2166
PositionKinase
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.06
Grand average of hydropathy-0.258
Instability index48.03
Isoelectric point8.73
Molecular weight240167.02
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09845
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.39|      26|      64|     953|    1014|       1
---------------------------------------------------------------------------
  983- 1009 (41.43/69.85)	LPLQPDDKTASKWRLgDEELLSVLYVL
 1939- 1964 (45.96/ 8.51)	LPLPPTNATALRRDV.DSLLEPPLDVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.09|      26|      64|     109|     134|       2
---------------------------------------------------------------------------
  109-  134 (49.11/31.53)	YGVP.LSGSLLIKPGVYPEQRPCNEDT
  172-  198 (43.98/27.40)	YNVPlLRATWFIKVTYLNQARPAPNST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.63|      40|      63|    2052|    2092|       3
---------------------------------------------------------------------------
  719-  745 (27.18/11.56)	.....RLVLSELSCGHSfYASGRGEYTSSSCI..........
 2052- 2092 (70.96/49.42)	QCqPPQLSLAALSPLQS.STSGVGPQQKSSCVSWVPTNVSVR
 2117- 2152 (64.49/40.02)	NC.PP..STASGSNGSS.GVTGDHANLKAS..SWLKGAVRVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      16|      64|     953|     974|       4
---------------------------------------------------------------------------
  953-  974 (23.90/21.50)	SVSS.....WLLKSIRqlvdgnGMTAS
 1015- 1035 (24.31/10.02)	SVSGvkfliWLLVKIR......GVGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     452.95|     141|     299|     479|     631|       5
---------------------------------------------------------------------------
  479-  631 (224.52/201.64)	ERWIKEVNPCLQ....SSLMWIGTVELSLICSiffLCEWATCDYRDCRASPSQNVKF..TGRRDLSQIHMAvsilkNKMDEMNNLSRPKSSTRIT...LNKVAKGSLNDACLTAAAVDDSSGlrSNAKNVDEKKDTNDIFEsPGPLHDiIVCWLDQHEVSNV
  787-  936 (228.43/168.98)	ESKLCEIKTSFQesvtSTLTQVETGEAKSGCE...DCMRSKGQKLDDSATPFQGFPLiqSGEEDIWWVKKG.....TKLQESFNVEPVQKSVKQTsrgRAKVVRKTQSLAQLAAARIEGSQG..ASTSHVCESKMSCPHHE.PNNDGD.NVKDFDHTRAANV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.61|      33|      63|    1350|    1382|       6
---------------------------------------------------------------------------
 1350- 1382 (52.64/37.66)	TSELSNSGKGF.VGRTAKVSAAISALVVG...AVVHG
 1412- 1448 (49.97/35.32)	TNGVSHPTGGFrIENSTEVSVHWFRILLGncrTVYDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.91|      41|      70|    1635|    1677|       7
---------------------------------------------------------------------------
 1635- 1671 (50.48/23.84)	.............................GKTTLESLRS....LSPKAEGFALSDSEKGFTEVILSRLLA
 1674- 1743 (47.13/25.05)	DAAPlyselvhllgklqeslvmdvkwilqGQDAILGRRStrqqLVHIAQRKGLSTKAQVWKPWGWSSLLS
 1744- 1805 (38.29/13.79)	DAIPnktakrklevtsieegevvddtvdaKRTTKTPPHS....VDRSFEG..IRSINKYLTEKALAEL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.02|      38|     433|    1135|    1179|      11
---------------------------------------------------------------------------
 1135- 1179 (54.44/48.95)	AELD.NGRSIDGDlvsssGilAGEEIDEQVRQ.KLNGRSSRLVQNMK
 1569- 1608 (58.58/35.73)	AIIDcNTPTIQGD.....G..ASEPCDPKDNElKLSERLMQLLDTLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09845 with Med12 domain of Kingdom Viridiplantae
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