<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09843

Description Polymerase II transcription-mediator1
SequenceMQRYAGFSGSRDGARLEASPFSSSSSSGYPVSSRRQQQLTPYKLKCDKDPLNNKLGPPDFYPQTLNCPEETLTKDYVQYGYKETVEGIEEAREIVISQIPYFCKPDVVIKCKEALKKRLRAINESRAQKRKAGQVYGVPLSGSLLIKPGVYPEQRPCNEDTRRKWVEALAQPNKRLRSLSEHVPHGYRRKSLFEGLIRYNVPLLRATWFIKVTYLNQLQARPAPNSTSVVASDNQRSNQWTKDVVEYLQQILDEVCSKEGAIVPPSFKEQSSPGLAAGTNQIKMKTESSPAGDSEEPLVHFKWRYMVRLIQWHLTEELLVPSVLIEWLSNQLQERDSDDVLELLLPIILGLVDTITLSQTYVRMFVELLVRRLNVDRPKRFSVSSVIAELLRYMVLAVPDTFVSLDCFPFPSFVVPDVYGRGALLKITSGGGILCSKRRDAYRYLSCGYAVSSIQKRAHDLAAVANPSLQARGAAKVVQALDKALVTGNLSVAYFSLFNDLSDALMEERWIKEVNPCLQSSLMWIGTVELSLICSIFFLCEWATCDYRDCRASPSQNVKFTGRRDLSQIHMAVSILKNKMDEMNNLSRPKSSTRITLNKVAKGSLNDACLTAAAVDDSSGLRSNAKNVDEKKDTNDIFESPGPLHDIIVCWLDQHEVSNVAGFTRVDVLIAELIRNGIFFPQVYVRQLIISGITDKNDTMLDVERKRRHHRTLKQLPGSSLFDVLEETRTAEEQQLYEMMSTYSSERRLVLSELSCGHSFYASGRGEYTSSSCIRKQSDLPVASEGDKHGRVLEQVEDVKALLSSLLGFTYPPLVESKLCEIKTSFQESVTSTLTQVETGEAKSGCEDCMRSKGQKLDDSATPFQGFPLIQSGEEDIWWVKKGTKLQESFNVEPVQKSVKQTSRGRAKVVRKTQSLAQLAAARIEGSQGASTSHVCESKMSCPHHEPNNDGDNVKDFDHTRAANVTAIGKSLKRLRLLERRSVSSWLLKSIRQLVDGNGMTASKATNSISILPLQPDDKTASKWRLGDEELLSVLYVLDTCCDSVSGVKFLIWLLVKIRGVGSSGQPGRTYMLMRNRDHQVCQVNEALVFSSLLRYENILLATDILPDVLSALVNRNSMSATTRHPGSTAFAYVRYFLKKYRDVASVAKWEKNFRTTCDQRLLAELDNGRSIDGDLVSSSGILAGEEIDEQVRQKLNGRSSRLVQNMKEIVQRQADGIQRSLKEKKVLAGAAPRNPLTFEKEDSYQIAHDIVLGLVECIRQNGGANPDGDLSIVASAVSAIVVNAGHMIAKHLDFAGGNYQGVNSVATSLNFVRHTLLIHINSLCLLKETLGDRFSRAFEIALAVETSAAVTAAFAPPKMHRNQFQPSPEAHDAYGNHTSELSNSGKGFVGRTAKVSAAISALVVGAVVHGAVSLERMVATLKIKDGLDIMQLLRGLKSNTNGVSHPTGGFRIENSTEVSVHWFRILLGNCRTVYDGLIADILGDPYIIALSRLQRMLPLTVIFPPAYSIFAMVLWRRYIFNCEDPQLYQSFSNAINDITRHQPFREIYFRNTHRLYNLLASDVGDSKFAAMLESHSPDRNSKILPFIPLRARLFLDAIIDCNTPTIQGDGASEPCDPKDNELKLSERLMQLLDTLQPAKFHWQWVEMRLLLDEQALMEKVAAGKTTLESLRSLSPKAEGFALSDSEKGFTEVILSRLLARPDAAPLYSELVHLLGKLQESLVMDVKWILQGQDAILGRRSTRQQLVHIAQRKGLSTKAQVWKPWGWSSLLSDAIPNKTAKRKLEVTSIEEGEVVDDTVDAKRTTKTPPHSVDRSFEGIRSINKYLTEKALAELVLPCIDRSSADIRGILSVDLTKQMGAISEHIKAIALNGAKQAGSVSSGNEVPSNKSSGRRGIRGGSPNIGRRAPVGNDPSPPSASALRAALWLRLQFIIRLLPVIMADRSMRHTLASAILGLLATRMIYEDADLPLPPTNATALRRDVDSLLEPPLDVLLDRPGESLFEKLLCVLHALLGSYKPSWLKSRSASRSSIKSQRDFSAFDNEAAEGLQSALDHMELPETIRRRIQAAMPLLPPSRRPCMQCQPPQLSLAALSPLQSSTSGVGPQQKSSCVSWVPTNVSVRSKAALPSHDPETEVDPWSLLEDGTNCPPSTASGSNGSSGVTGDHANLKASSWLKGAVRVRRTELTYIGSVDDDS
Length2195
PositionKinase
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.06
Grand average of hydropathy-0.265
Instability index48.43
Isoelectric point8.75
Molecular weight243240.18
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09843
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.39|      26|      64|     982|    1043|       1
---------------------------------------------------------------------------
 1012- 1038 (41.43/88.05)	LPLQPDDKTASKWRLgDEELLSVLYVL
 1968- 1993 (45.96/10.68)	LPLPPTNATALRRDV.DSLLEPPLDVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.63|      40|      63|    2081|    2121|       2
---------------------------------------------------------------------------
  748-  774 (27.18/ 9.27)	.....RLVLSELSCGHSfYASGRGEYTSSSCI..........
 2081- 2121 (70.96/40.02)	QCqPPQLSLAALSPLQS.STSGVGPQQKSSCVSWVPTNVSVR
 2146- 2181 (64.49/32.38)	NC.PP..STASGSNGSS.GVTGDHANLKAS..SWLKGAVRVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      16|      64|     982|    1003|       3
---------------------------------------------------------------------------
  982- 1003 (23.90/25.62)	SVSS.....WLLKSIRqlvdgnGMTAS
 1044- 1064 (24.31/11.98)	SVSGvkfliWLLVKIR......GVGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     504.71|     160|     304|     483|     660|       4
---------------------------------------------------------------------------
  483-  660 (243.06/222.02)	KALVTGNLSVAYFSLfndLSDALMEerwIK.EVNPCLQSSLMWIGTVELSLICSiffLCEWATCDYRDCRASPSQNVKF..TGRRDLSQIHMAvsilkNKMDEMNNLSRPKSSTRIT...LNKVAKGSLNDACLTAAAVDDSSGlrSNAKNVDEKKDTNDIFEsPGPLHDiIVCWLDQHEVSNV
  800-  965 (261.64/184.26)	KALLSSLLGFTYPPL...VESKLCE...IKtSFQESVTSTLTQVETGEAKSGCE...DCMRSKGQKLDDSATPFQGFPLiqSGEEDIWWVKKG.....TKLQESFNVEPVQKSVKQTsrgRAKVVRKTQSLAQLAAARIEGSQG..ASTSHVCESKMSCPHHE.PNNDGD.NVKDFDHTRAANV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.61|      33|      63|    1379|    1411|       6
---------------------------------------------------------------------------
 1379- 1411 (52.64/39.80)	TSELSNSGKGF.VGRTAKVSAAISALVVG...AVVHG
 1441- 1477 (49.97/37.33)	TNGVSHPTGGFrIENSTEVSVHWFRILLGncrTVYDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.91|      41|      70|    1664|    1706|       7
---------------------------------------------------------------------------
 1664- 1700 (50.48/27.05)	.............................GKTTLESLRS....LSPKAEGFALSDSEKGFTEVILSRLLA
 1703- 1772 (47.13/28.42)	DAAPlyselvhllgklqeslvmdvkwilqGQDAILGRRStrqqLVHIAQRKGLSTKAQVWKPWGWSSLLS
 1773- 1834 (38.29/15.75)	DAIPnktakrklevtsieegevvddtvdaKRTTKTPPHS....VDRSFEG..IRSINKYLTEKALAEL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.02|      38|     433|    1164|    1208|      12
---------------------------------------------------------------------------
 1164- 1208 (54.44/45.71)	AELD.NGRSIDGDlvsssGilAGEEIDEQVRQ.KLNGRSSRLVQNMK
 1598- 1637 (58.58/33.35)	AIIDcNTPTIQGD.....G..ASEPCDPKDNElKLSERLMQLLDTLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09843 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSVSSGNEVPSNKSSGRRGIRGGSPNIGRRAPVGNDPS
2) RSKAALPSHDPETEVDPWSLLEDGTNCPPSTASGSNGSSGVTGDHANL
1877
2121
1914
2168










Molecular Recognition Features






MoRF SequenceStartStop




1) MQRYAGF
1
7