<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09772

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMDGGHTTRHPMSPAISASTVLPQQRQMQPHHHPARPAIADLFTLYLGVRASLAPKFLISSRVGVSLLVLTLGVVGLQMNSKQRAEDPLRESSNKLQKRVTALNRDLPPRDEQFISDYEQLRMQFPDAEQLQAITESVLISFVLQCSSHAPQSEFLLFATRCLCARGHLRWDSLLPSLLNTVSSIEAPMVQGVSVTGGGSVTPSSAITMPNAPNFHQSNPASPLSVMNTIGSPTQSGIDQPVGANVSPIKAAEFSSSAQLGTAARGDQSRRGAEASYLHHLSCRIILAGLEFNLKPATHAVIFQHMVNWLVNWDQRPQGMDETDTMQTCRLEKPLHEWMHLCLDVIWILVNEDKCRIPFYELVRCNLQFLENIPDDEALVSIIMEIHRRRDMVCMHMQMLDQHLHCPTFGTHRFLSQSYPSIAGESVTNLRYSPITYPSVLGEPLHGEDLANSIPKGGLDWERALRCLRHALRTTPSPDWWRRVLLVAPCYRSQSQQSSTPGAVFSPDMIGEAVADRTIELLKLTNSETQCWQDWLLFADIFFFLMKSGCIDFLDFVDKLASRVTNSDQQILRSNHVTWLLAQIIRIEIVMNTLSSDPRKVDTTRKIISFHKEDKSLDANNIGPQSILLDFISSSQTLRIWSFNTSIREHLNSDQLQKGKQIDEWWKQMMKASGERMIDFTNLDERATGMFWVLSFTMAQPACEAVMNWFTSAGMADLIQGPNMQPSERIMMMRETYPLSMSLLSGLSINLCLKLAYQLEETIFLGQAVPSIAMVETYVRLLLIAPHSLFRPHFTALTQRSPSILSKSGVSLLLLEILNYRLLPLYRYHGKSKALMYDVTKIISMIKGKRGEHRLFRLAENLCMNLILSLKDFFFVKKELKGPTEFTETLNRITIISLAITIKTRGIAEVEHMIYLQPLLEQIMATSQHTWSEKTLRYFPPLIRDFLMGRVDKRGLAIQAWQQAETTVINQCNQLLSPSAEPNYVMTYLSHSFPQHRQYLCAGAWMLMNGHLEINSANLARVLREFSPEEVTANIYTVVDVLLHHIQCEVQRGHLAQDLLSKAITNLSFFIWTHELLPLDILLLALIDRDDDPYALRLVISLLEKPELQQRVKNFCNTRSPEHWLKNQHPKRAELQKALGSHLSWKDRYPPFFDDIAARLLPVIPLIIYRLIENDATDIADRVLAFYSSLLAFHPLRFTFVRDILAYFYGHLPIKLIGRILNLLGVSTKTPFSESFAKYLVSSNSSICPPPEYFANLLLNLVNNVIPPLSSKSKSNPADTTRSTFNKHHASSQPGGVGNTDGQRAFYQNQDPGSYTQLVLETAAIEILSLPVPAAQIVSSLVQIIAHVQAILIQSNSGQGMSGGLGQSSGLPTSPSGAAESSGPNQANSAATGINATNFVSRSGYSCQQLSVLMIQACGLLLAQLPPEFHMQLYSEAARVIKDCWWLADGSRPVKELDSAVGYALLDPTWASQDNTSTAIGNIVALLHSFFSNLPQEWLESTHTVIKHLRPVNSVAMLRIAFRILGPLLPRLAFARPLFMKTLALLFNVLGDVFGKNPQVSNPNPVEASEIADIIDFLHHAVMYEGQGGPVQSTSKPKLEILTLCGKVIEILRPDVQHLLSHLKIDPTSSIYAATHPKLVQNPS
Length1643
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.08
Grand average of hydropathy-0.051
Instability index45.55
Isoelectric point7.10
Molecular weight184055.24
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09772
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.84|      15|      15|    1235|    1249|       1
---------------------------------------------------------------------------
 1235- 1249 (27.77/15.29)	FAKYLVSSNSSICPP
 1253- 1267 (26.07/13.92)	FANLLLNLVNNVIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.32|      19|      23|    1165|    1186|       3
---------------------------------------------------------------------------
 1165- 1186 (22.82/24.74)	LIIYRLIEndATDIADrVLA.FY
 1189- 1208 (28.50/16.59)	LLAFHPLR..FTFVRD.ILAyFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      13|      15|     412|     424|       4
---------------------------------------------------------------------------
  412-  424 (24.35/12.23)	RFLSQSYPSIAGE
  430-  442 (25.28/12.96)	RYSPITYPSVLGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.27|      16|      18|    1351|    1366|       5
---------------------------------------------------------------------------
 1351- 1366 (29.56/19.25)	LIQSNSGQGMSGGLGQ
 1370- 1385 (29.71/19.39)	LPTSPSGAAESSGPNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.98|      22|      23|     202|     223|       7
---------------------------------------------------------------------------
  202-  223 (40.75/24.77)	PSSAITMPNAPNFHQSNPA..SPL
  225-  248 (34.23/19.53)	VMNTIGSPTQSGIDQPVGAnvSPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.73|      18|      23|     460|     477|       8
---------------------------------------------------------------------------
  460-  477 (36.48/23.27)	WERAL...RCLRHALR..TTP....SP
  480-  506 (22.25/10.98)	WRRVLlvaPCYRSQSQqsSTPgavfSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.90|      11|      23|     328|     341|       9
---------------------------------------------------------------------------
  328-  341 (17.26/18.14)	CRLekPLHEWMHlC
  354-  364 (23.65/12.08)	CRI..PFYELVR.C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.89|      10|      18|    1119|    1129|      11
---------------------------------------------------------------------------
 1119- 1129 (17.92/15.51)	SPEHWlKNQHP
 1140- 1149 (20.97/12.62)	SHLSW.KDRYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.39|      10|      20|     914|     923|      12
---------------------------------------------------------------------------
  914-  923 (18.02/ 8.32)	YLQPLLEQIM
  937-  946 (19.37/ 9.47)	YFPPLIRDFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09772 with Med23 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KSKSNPADTTRSTFNKHHASSQPGGVGNTDGQRAFYQ
2) MDGGHTTRHPMSPAISASTVLPQQRQMQPHHHP
1271
1
1307
33










Molecular Recognition Features






MoRF SequenceStartStop




NANANA