<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09709

Description RBR-type E3 ubiquitin transferase
SequenceMASCGGGVCLKRDRREEEENDDDKGETSGRNKRPSSGAYYTGAGVDAQRTDDDDSAAADYMYEYDDGYEEEESAAEQPKGDDASARDTEQRYAVLTEDDVRARQEADTARVAEVLSIPAGFARALLRHFKWRVGRAQEEWFSDAQHQQRVRGAVGLVPAACPDGDALVPAARSPRPRVCGICFDAFPAGGTRSAGCAAHYYCDGCWCGYVAAAVGDGARCLALRCPDPSCAAAVVRELVDEVARDDDRARYARFWLRSYVEESGGRIRWCGGAGCTRSVELLGGCDAEAVASAVDVVCGCRHAFCWRCGEEAHRPVSCGTVRAWLAKNASDSETANWVVANTKRCPMCRRPIEKNHGCNHMTCGAPCHHQFCWLCLDPWDHHRGCTRYDSRRRRRHGPVDEVEDEEEQAQRTLAKASLDRYLYHYERWEGNGKSLRKALADADELERSELQRMARLLDLPAMDLGFVTEAYRQIADGRRVLRWAHAYDYFLSLDPERDAAKRGLFDDLQSQANRWLECLHGCAELERKHLFGAADADAEDEPTVAAAAFMAYKERLANLTGVTRRFIGNLVRAFKTNLPEVVVTLTPPASDLQHIVKSGPTTERQTTVGIGGILSTEATVTLPVSNVSSLQGTSALRPSSSSLVVSQETDIANDSVQERHSPTRNLAQAQHPVRPGGHGGFLSNPYPSFFGEATSTAGPLQLYMPNMVVSGGTTSTPSLAFSLSALGQPITSTALGGSFGSNTRTAWGNSDMAAASSSQPDRMGMDQQAGTGSAMNLTIGLHPNAQQPPPKYVKIWEGDLYGQRQGQPVFISKLESWGGTVSRKYSESQYVGNTDFLIFRALNQHGFLGQLQERKLCGVIQLPSQTLLLSMYDKTSRMVGMLFPKNMLMFRPEALTQPSPVQQEELIHHQQQQLQQQQRNIHRLQRQLIQKQQQQHMQKLLPQRLQYQEQLHLQQQMTQQIQQQQQSLYQQHQQMQHQQQLWQQIQQQKHQLQHMDPQQQQLLSQMVGTELGSDDDTREDWVTGAGPHA
Length1029
PositionUnknown
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.07
Grand average of hydropathy-0.613
Instability index60.10
Isoelectric point6.04
Molecular weight114444.55
Publications









Function






Annotated function


GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
ubiquitin ligase complex	GO:0000151	IBA:GO_Central

GO - Biological Function
ligase activity	GO:0016874	IEA:UniProtKB-KW
metal ion binding	GO:0046872	IEA:UniProtKB-KW
ubiquitin conjugating enzyme binding	GO:0031624	IBA:GO_Central
ubiquitin protein ligase activity	GO:0061630	IBA:GO_Central

GO - Biological Process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436	IBA:GO_Central
protein polyubiquitination	GO:0000209	IBA:GO_Central
ubiquitin-dependent protein catabolic process	GO:0006511	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09709
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.50|      20|      21|     947|     966|       1
---------------------------------------------------------------------------
  903-  919 (23.84/ 8.95)	.Q..EELiHHQQQ...QLQQQQR
  947-  966 (42.11/20.88)	YQ..EQL.HLQQQMTQQIQQQQQ
  969-  989 (30.55/13.33)	YQqhQQM.QHQQQLWQQIQQQK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     261.49|      51|      62|     134|     184|       2
---------------------------------------------------------------------------
  134-  182 (85.74/47.28)	............GRAQEE..WFSD..AQHQQRVR..GAV..GLVPAACPDGDALVPAARSPRPRVCGIC
  183-  233 (65.64/34.35)	FDafpaggtrsaGCA.AH..YYCD..GCWC...........GYVAAAVGDG.ARCLALRCPDPS.CAAA
  239-  300 (55.53/27.85)	VD....evarddDRARYArfWLRSyvEESGGRIRwcGGA..GCTRSVELLGGCDAEAVASAVDVVCG.C
  301-  348 (54.58/27.24)	RH....afcwrcG...EE........A.HRPVSC..GTVraWLAKNASDSETANWVVANTKR...CPMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.66|      25|      25|      40|      64|       3
---------------------------------------------------------------------------
   40-   64 (44.08/26.72)	YTGAGVDAQRTDDDDSAAADYMYEY
   68-   92 (42.58/25.55)	YEEEESAAEQPKGDDASARDTEQRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.84|      46|      65|     586|     649|       4
---------------------------------------------------------------------------
  586-  649 (62.25/74.91)	TPPASDL...QHIVKSGptterqttvGIGGILSTeatvtlPV....SNVSSLQGTSALR.PsssSLVVSQET
  660-  713 (74.59/47.23)	HSPTRNLaqaQHPVRPG.........GHGGFLSN......PYpsffGEATSTAGPLQLYmP...NMVVSGGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.56|      16|      66|     922|     945|       5
---------------------------------------------------------------------------
  922-  943 (20.43/28.25)	HRLQRqlIQKQQQQhmqkLLPQ
  990- 1005 (32.13/13.87)	HQLQH..MDPQQQQ....LLSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.77|      23|      25|     396|     420|       6
---------------------------------------------------------------------------
  396-  420 (32.22/23.57)	HgpVDEVEDEEEQAQRTL....AKAS.LDR
  424-  447 (31.35/15.77)	H..YERWEGNGKSLRKAL....ADADeLER
  506-  527 (20.20/ 6.89)	.......DDLQSQANRWLeclhGCAE.LER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.52|      26|      46|     747|     773|       7
---------------------------------------------------------------------------
  747-  773 (43.39/27.53)	WgNSDMAAASSSQPDRMG.MDQQAGTGS
  796-  822 (44.13/23.25)	W.EGDLYGQRQGQPVFISkLESWGGTVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.62|      12|      19|     551|     563|      10
---------------------------------------------------------------------------
  551-  563 (15.35/17.01)	AYKERLANLTgVT
  573-  584 (20.27/15.09)	AFKTNLPEVV.VT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.00|      14|      24|     855|     869|      11
---------------------------------------------------------------------------
  855-  869 (18.77/17.86)	KLCGVIqLPSQTLLL
  877-  890 (26.23/19.14)	RMVGML.FPKNMLMF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09709 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GVCLKRDRREEEENDDDKGETSGRNKRPSSGAYYTGAGVDAQRTDDDDSAAADYMYEYDDGYEEEESAAEQPKGDDASARDTEQRYAVLTEDDV
2) QHMDPQQQQLLSQMVGTELGSDDDTREDWVTGAGPHA
3) SQETDIANDSVQERHSPTRNLAQAQHPVRPGGHGGFLSNPYPS
7
993
646
100
1029
688










Molecular Recognition Features






MoRF SequenceStartStop




1) DSAAADYMYEYDDGYEE
2) ETSGRNKRPSSGAYYTGAGVDAQRTD
3) VCLKRDRREEE
54
26
8
70
51
18