<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09679

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMAAADRQLVVAVEGTAALGPYWSTIVAEYVEKIVRSFCASELPGQKLVGTPPELALVVFHTHGPYSAFDVQRSGWTKDVDAFLSWLSGILFSGGGFSEASTCEGLAEALKILQGNPNTTQGHQNHEAQKHCILVAASNPYPLPTPVYCLPTQSTDHKENIETSKEPSIADAETVAKSFAQCSVSLSVISPKQLPTLKAIYNAGKRNLRAADPSVDHAKNPHFLVLLSENFMEARTALSRPLHGNLAPNQTITKMDTAPAVTMPGPTSNGNSSVNAMAGRQPIVGGISTTSVKVEPTTMPPIVSAPAFSHVTPISNVASQGISALQTSSPSLISQEANMGNDNVQEHKPIINPVQQPIRPGGHGSLLNNLSQVRLMNSTSLGGGATSMGLPNMGATPIQVHMSNMISSGMTSTPSVISSMSGPGQPISTQQMVQSTALGSFGSNTPTVTGNSTIAVSSSLTNNQSSMGMGQSVQSVAQGGLVSGSQLGQGGIVANQNVMSTLGPTAISSTPAMMPTPGMVPQTGVNSLGVNNNSAMNMPITQQHANAQQPPPKYVKIWEGTLSGQRQGQPVIICKLEGYRSGTASETLAADWPETMQIVRLIAQEHMNNKQYVGKADFLVFRTLNHHGFLVQLQEKKLCAVIQLPSQTLLLSMADKAGRLIGMLFPGDMVVFKPQASTQQTPMQQQQLQQFQQQQQQLQQHMHMQPQGLPLQQSQMQLQQQQPQMQPMQQQQPSQMQQQMQSMQQQMQPMQQQMQHQQQQMQHQQQQMQQMQQQQQQQQQQQQQIQPQQQQMQQMQQQQQQQMQPQQQQMQQMQQQQQQMQPQQQQMQQMQQQQQQMQPQQQQQPQMVGTGMGQQFMQGHNRAVQMMQGKITPQGPGSMPGGGFLP
Length885
PositionUnknown
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.04
Grand average of hydropathy-0.517
Instability index54.21
Isoelectric point8.37
Molecular weight96296.22
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09679
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.57|      15|      15|     802|     816|       1
---------------------------------------------------------------------------
  754-  770 (31.74/ 6.09)	QHQQ.qqMQHQQQQMQQM
  778-  794 (32.26/ 6.32)	QQQQ.qqIQPQQQQMQQM
  795-  812 (34.59/ 7.30)	QQQQqqqMQPQQQQMQQM
  813-  829 (34.99/ 7.47)	QQQQ.qqMQPQQQQMQQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     593.06|     135|     138|     188|     324|       2
---------------------------------------------------------------------------
   82-  171 (104.20/37.27)	.......................................FLSWLSGILFSG.........GGFSEASTCEGLAEAL.KILQGNPnTTQGHQ......NHEAQK.HCIL..VAAS......NPYPLPtPVYCLPTQStdHKEN.........IE.....TSKEPSI.ADA
  188-  324 (223.71/92.51)	ISPKQLPTLKAiyNAGKRNLRAADPSVDHAKNP.....HFLVLLSENFMEARTALSRPLHGNLAPNQTITKMDTAP.AVTMPGP.TSNGNSS....VNAMAGR.QPIV..GGISTTSVKVEPTTMP.PIVSAPAFS..HVTP.........IS.....NVASQGI.SAL
  327-  472 (158.58/60.84)	SSP.SLISQEA..NMGNDNVQEHKPIINPVQQPirpggHG.SLL.NNLSQVRLMNSTSLGGG.ATSMGLPNMGATPiQVHMSNM.ISSGMTStpsvISSMSGPgQPI.......STQQMVQSTAL.......GSFG..SNTPtvtgnstiaVSssltnNQSSMGMgQSV
  473-  550 (106.57/38.62)	QSVAQ.........GG...L......VSGSQLG..........................QGGIVANQNV..MSTL.......GP.TA..ISS....TPAMMPT.PGMVpqTGVNSLGVNNNSAMNM.PITQQHANA..QQPP...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.65|      12|      86|     740|     752|       4
---------------------------------------------------------------------------
  740-  752 (22.20/ 7.72)	QSMQQQMQPmQQQ
  830-  841 (28.45/ 7.12)	QQQQQQMQP.QQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09679 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALSRPLHGNLAPNQTITKMDTAPAVTMPGPTSNGNSSVNAMAGRQP
2) GMTSTPSVISSMSGPGQPISTQQMVQSTALGSFGSNTPTVTGNSTIAVSSSLTNNQSSMGMGQSVQSVAQGGL
3) GPTAISSTPAMMPTPGMVPQTGVNSLGVNNNSAMNMPITQQHANAQQPPPKYVKIWEG
4) LQTSSPSLISQEANMGNDNVQEHKPIINPVQQPIRPGGHGSLLNNLSQV
5) NSTSLGGGATSMGLPNMGATPIQVHMSNMIS
6) QIQPQQQQMQQMQQQQQQQMQPQQQQMQQMQQQQQQMQPQQQQMQQMQQQQQQMQPQQQQQPQMVGTGMGQQFMQGHNRAVQMMQGKITPQGPGSMPGGGFLP
7) QQQLQQHMHMQPQGLPLQQSQMQLQQQQPQMQPMQQQQPSQMQQQMQSMQQQMQPMQQQMQHQQQQMQHQQQQMQQM
236
408
502
324
376
783
694
281
480
559
372
406
885
770










Molecular Recognition Features






MoRF SequenceStartStop




NANANA