<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09663

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEESYLALRELVEKSQAEAEGKGIGAGANGSWQRSDTEKKIDLLKFITRTRQRMLRLHVLAKWCQQVPLVHYCQQLGSTLHSHETCFTQTADSLFYMHECLQQARAPMFDVPSAIEVMLTGGYQRLPRCIEEIGSQHKLSPDEEKRALRKLDASVRYRVLVTPRPKEVSNVSVTDGIAVFRVDGEFKILLTLGYRGNVDLWRILHMELLVGEKKGPIKLDESRRFALGDDIERRMAASENPFAVLYAILHEFCISLAMDTIIKQANVLRQGRWKDAIRSELISDSATVQTGNTPLMQLVQDAEFDSSGFKIPGLKVNYWLDEKSTSTAEPDSSPFIKIEAGLDMQIKCQHSSFILDPFTDKEASLSLDLSCIDVEQLILRAVSCNRHTRLLNIQRQLCKNVQIFQSPKDVVLTRDVAAAKDPMMNAEKGFSDCFGNEVLQVRACGQAYVSLGINIRSGRFLLQSPENILPRAALMDCEEALNKGSTSATEVFSSLRTRSILHLLAATGSFFGLKVYQQSQGTLKIPKTLLHGSDLMVMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDANGNTNASGDVKEAIRYNKINIGQMQILKNEMNENPFDVKLQALQSLVDSADMMESDLPVQNAIEPLPLLPACSPSFSSIVDEVFEYERGSTAAQNRCLPVDIQGINARVVSPMHDGCLSYTQANNNMNVHPNVSLNSYFPSNFRHLQGANKSLQLVPSSNDNSNQIPAQSSHSGNLGNATPGHLIGSSTTTGGLGKLITAGSDGASRKHYLSDFLSSIPSLRGLQPSEPRKRRKKTESVQSLLPLQAHSSNLQSRGSLTYGDVLAERNNCVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRRPSSNLWLRLPFAQDDSWNHICLRLGKAGSMSWDVRINDPHFRELWELNGGSTKTQWGVGIRIANSSEMDSHISFDSSGVVLTYNTVEADSVQKLVSDLRRLSNARSFALGMRRLIGVKFQDKLDDNQLTMEVKSQSVNKGNSDAADKLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHIVVEWEIAKAGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVAVSSGYSSMPKQPNIPTQGPLVNGSSSTIHHAPGPSNAASAHLGSHNLHAAAMLSAVGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNATQASGHLNNNAGVPQTAPSANRLNATPGVSMVRPTSGVANHVAASLSRAGNAMLASSALASGISGTSVRLTAGAGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAVEINEICDYFSRRVASEPYDASRVASFITLLTLPILVLREFLKLITWKKGLSPVHGDIATAQRARIELCLENHSGSASSDNTENSSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVKLRYSFGDNNHIAFLAMNGSHGGRACWLQFEEWERCKQKVSRAVETVNGSGVAGEVGQGRLRMVAEMIQKQLQLCLQQLRDDPLSAGSTAS
Length1721
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.07
Grand average of hydropathy-0.159
Instability index49.09
Isoelectric point8.06
Molecular weight188569.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
plasmodesma	GO:0009506	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
cold acclimation	GO:0009631	IEA:EnsemblPlants
positive regulation of cell population proliferation	GO:0008284	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
systemic acquired resistance	GO:0009627	IEA:EnsemblPlants









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09663
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.98|      13|      15|     754|     766|       1
---------------------------------------------------------------------------
  754-  766 (23.35/13.04)	QIPAQSSHSGNLG
  772-  784 (22.63/12.39)	HLIGSSTTTGGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.58|      76|     595|     651|     739|       3
---------------------------------------------------------------------------
  651-  739 (125.81/96.48)	AIEPLPLLPACSPSFSSIVDevfeyerGS.TAAQNRCLPVD..IQGINArvvspMHDGCLSYTQA....NNNMNV...HPNVS.LNSyFP..SNFRHLQG.AN
 1246- 1335 (110.77/61.10)	AGDQVWLQPATPPKGGPSVG.......GSlPCPQFRPFIMEhvAQGLNA.....LEPNFMNATQAsghlNNNAGVpqtAPSANrLNA.TPgvSMVRPTSGvAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.35|      27|     595|     423|     451|       4
---------------------------------------------------------------------------
  423-  450 (42.87/40.06)	FQSPKDvVLTRDVAAAKDPMMN.....AEKGFS
  481-  512 (40.48/25.89)	LQSPEN.ILPRAALMDCEEALNkgstsATEVFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.43|      15|      21|     353|     367|       6
---------------------------------------------------------------------------
  331-  345 (24.35/15.30)	PGLKVNYWLDEKSTS
  353-  367 (26.89/17.70)	PFIKIEAGLDMQIKC
  376-  390 (24.18/15.13)	PFTDKEASLSLDLSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.24|      14|      17|    1194|    1208|       7
---------------------------------------------------------------------------
 1194- 1208 (21.24/16.42)	LHAAAML....SAVGRgGP
 1210- 1227 (18.99/ 8.66)	LVPSSLLpfdvSVVLR.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.83|      72|     648|     160|     325|       8
---------------------------------------------------------------------------
  161-  247 (89.29/145.76)	DEEKRALRKLD.ASVRYRVLVTPRpkeVSNVSVTDGIAVFRVDGefkILLTlgYrGNVDLWRIlhmELLVGEKKgpiKLDESRRFALG
  942- 1014 (120.54/51.44)	DPHFRELWELNgGSTKTQWGVGIR...IANSSEMDSHISFDSSG...VVLT..Y.NTVEADSV...QKLVSDLR...RLSNARSFALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.00|      17|      18|    1392|    1409|       9
---------------------------------------------------------------------------
 1392- 1409 (25.26/17.51)	Y.GGGWVpLAALKKVLRGI
 1412- 1429 (24.74/11.53)	YlGVLWL.FAQLPELLKEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.20|      22|     664|     451|     479|      10
---------------------------------------------------------------------------
  451-  479 (34.38/34.92)	DCfgnevlqVRACGQAYVSLGINIRSGRF
 1123- 1144 (39.82/23.60)	DC.......IRLTAGPLLALGGAIRPARM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09663 with Med14 domain of Kingdom Viridiplantae
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