<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09659

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLRLHVLAKWCQQVPLVHYCQQLGSTLHSHETCFTQTADSLFYMHECLQQARAPMFDVPSAIEVMLTGGYQRLPRCIEEIGSQHKLSPDEEKRALRKLDASVRYRVLVTPRPKEVSNVSVTDGIAVFRVDGEFKILLTLGYRGNVDLWRILHMELLVGEKKGPIKLDESRRFALGDDIERRMAASENPFAVLYAILHEFCISLAMDTIIKQANVLRQGRWKDAIRSELISDSATVQTGNTPLMQLVQDAEFDSSGFKIPGLKVNYWLDEKSTSTAEPDSSPFIKIEAGLDMQIKCQHSSFILDPFTDKEASLSLDLSCIDVEQLILRAVSCNRHTRLLNIQRQLCKNVQIFQSPKDVVLTRDVAAAKDPMMNAEKGFSDCFGNEVLQVRACGQAYVSLGINIRSGRFLLQSPENILPRAALMDCEEALNKGSTSATEVFSSLRTRSILHLLAATGSFFGLKVYQQSQGTLKIPKTLLHGSDLMVMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDANGNTNASGDVKEAIRYNKINIGQMQILKNEMNENPFDVKLQALQSLVDSADMMESDLPVQNAIEPLPLLPACSPSFSSIVDEVFEYERGSTAAQNRCLPVDIQGINARVVSPMHDGCLSYTQANNNMNVHPNVSLNSYFPSNFRHLQGANKSLQLVPSSNDNSNQIPAQSSHSGNLGNATPGHLIGSSTTTGGLGKLITAGSDGASRKHYLSDFLSSIPSLRGLQPSEPRKRRKKTESVQSLLPLQAHSSNLQSRGSLTYGDVLAERNNCVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRRPSSNLWLRLPFAQDDSWNHICLRLGKAGSMSWDVRINDPHFRELWELNGGSTKTQWGVGIRIANSSEMDSHISFDSSGVVLTYNTVEADSVQKLVSDLRRLSNARSFALGMRRLIGVKFQDKLDDNQLTMEVKSQSVNKGNSDAADKLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHIVVEWEIAKAGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVAVSSGYSSMPKQPNIPTQGPLVNGSSSTIHHAPGPSNAASAHLGSHNLHAAAMLSAVGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNATQASGHLNNNAGVPQTAPSANRLNATPGVSMVRPTSGVANHVAASLSRAGNAMLASSALASGISGTSVRLTAGAGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAVEINEICDYFSRRVASEPYDASRVASFITLLTLPILVLREFLKLITWKKGLSPVHGDIATAQRARIELCLENHSGSASSDNTENSSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVKLRYSFGDNNHIAFLAMNGSHGGRACWLQFEEWERCKQKVSRAVETVNGSGVAGEVGQGRLRMVAEMIQKQLQLCLQQLRDDPLSAGSTAS
Length1649
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.07
Grand average of hydropathy-0.139
Instability index49.85
Isoelectric point7.97
Molecular weight180683.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
plasmodesma	GO:0009506	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
cold acclimation	GO:0009631	IEA:EnsemblPlants
positive regulation of cell population proliferation	GO:0008284	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
systemic acquired resistance	GO:0009627	IEA:EnsemblPlants









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09659
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.98|      13|      15|     682|     694|       1
---------------------------------------------------------------------------
  682-  694 (23.35/12.36)	QIPAQSSHSGNLG
  700-  712 (22.63/11.75)	HLIGSSTTTGGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.58|      76|     595|     579|     667|       3
---------------------------------------------------------------------------
  579-  667 (125.81/105.08)	AIEPLPLLPACSPSFSSIVDevfeyerGS.TAAQNRCLPVD..IQGINArvvspMHDGCLSYTQA....NNNMNV...HPNVS.LNSyFP..SNFRHLQG.AN
 1174- 1263 (110.77/66.57)	AGDQVWLQPATPPKGGPSVG.......GSlPCPQFRPFIMEhvAQGLNA.....LEPNFMNATQAsghlNNNAGVpqtAPSANrLNA.TPgvSMVRPTSGvAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.35|      27|     595|     351|     379|       4
---------------------------------------------------------------------------
  351-  378 (42.87/30.77)	FQSPKDvVLTRDVAAAKDPMMN.....AEKGFS
  409-  440 (40.48/19.84)	LQSPEN.ILPRAALMDCEEALNkgstsATEVFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.43|      15|      21|     281|     295|       6
---------------------------------------------------------------------------
  259-  273 (24.35/15.13)	PGLKVNYWLDEKSTS
  281-  295 (26.89/17.55)	PFIKIEAGLDMQIKC
  304-  318 (24.18/14.96)	PFTDKEASLSLDLSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.24|      14|      17|    1122|    1136|       7
---------------------------------------------------------------------------
 1122- 1136 (21.24/14.58)	LHAAAML....SAVGRgGP
 1138- 1155 (18.99/ 7.72)	LVPSSLLpfdvSVVLR.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.83|      72|     648|      88|     253|       8
---------------------------------------------------------------------------
   89-  175 (89.29/145.05)	DEEKRALRKLD.ASVRYRVLVTPRpkeVSNVSVTDGIAVFRVDGefkILLTlgYrGNVDLWRIlhmELLVGEKKgpiKLDESRRFALG
  870-  942 (120.54/51.21)	DPHFRELWELNgGSTKTQWGVGIR...IANSSEMDSHISFDSSG...VVLT..Y.NTVEADSV...QKLVSDLR...RLSNARSFALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.00|      17|      18|    1320|    1337|       9
---------------------------------------------------------------------------
 1320- 1337 (25.26/15.80)	Y.GGGWVpLAALKKVLRGI
 1340- 1357 (24.74/10.40)	YlGVLWL.FAQLPELLKEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.20|      22|     664|     379|     407|      10
---------------------------------------------------------------------------
  379-  407 (34.38/31.75)	DCfgnevlqVRACGQAYVSLGINIRSGRF
 1051- 1072 (39.82/21.44)	DC.......IRLTAGPLLALGGAIRPARM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09659 with Med14 domain of Kingdom Viridiplantae
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