<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09633

Description Uncharacterized protein
SequenceMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYCLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSWLPPTTPMKMGLAPTMMICLLTFHSQMIWTMILAY
Length603
PositionMiddle
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.06
Grand average of hydropathy-0.521
Instability index73.86
Isoelectric point6.45
Molecular weight66979.73
Publications
PubMed=17431167

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP09633
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     345.84|      61|      93|     292|     352|       1
---------------------------------------------------------------------------
  187-  239 (62.52/23.61)	............CGM...PLT.....................PPTSP.E..QailGESGGMQSAASHLVSQDGGMITMHSPKRSGKIP..PKLH
  242-  288 (47.44/16.22)	MVHRVW....KECILnrTQSK.....................RSQMS.T..P...TLEEEPASNPATWDFVDPTQRVS................
  292-  352 (103.23/43.58)	SRHKLL....KRCAV..GPNR.....................PPTMS.Q..P...GFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIP
  387-  458 (54.76/19.81)	SSRKYD....KQMAV...PSRntskqmnlnpmdsphspisplPPTLSpQ..P......RG.QETESLDPPSVPVNPAL....YGNGLELQQL..
  485-  527 (40.13/12.63)	............CGI..RPSN.....................PESSE.KwwH...SYCLPPSDDAEFRPPELQGERCDAKME............
  536-  577 (37.76/11.47)	..QRLLaqpnKRFKI..WQDK.....................QPQM..Q..P...LHFLDPLPLSWLPPTTPMK....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.04|      75|      93|       8|      84|       2
---------------------------------------------------------------------------
    8-   84 (126.78/86.32)	IGKW.FVRPYEKDEKPVNKSE.HLSCAFTFFLHGESnVCTSVEIAQHQPIYLINEEHIHMAQS.SPAPFQVLVSPYGLnG
  102-  179 (117.27/71.45)	IEEWqYFYPMVLKKKEESKEEdELGYDDDFPVAVEV.IVGGVRMVYPSAFVLISQNDIPVPQSvASAGGHITVGQQGL.G
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09633 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ECILNRTQSKRSQMSTPTLEEEPASNPATWDFV
2) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLH
3) KRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYG
249
171
298
281
239
450










Molecular Recognition Features






MoRF SequenceStartStop




NANANA