<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09618

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFACLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNRQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSTLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGITECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQQPQPQQPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2148
PositionKinase
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.435
Instability index59.09
Isoelectric point7.89
Molecular weight240363.05
Publications
PubMed=17431167

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09618
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.95|      18|      18|    1892|    1909|       1
---------------------------------------------------------------------------
 1892- 1909 (35.76/15.43)	QRLLRQAQTRPFQQGQPG
 1992- 2009 (22.93/ 6.98)	PSGYVQQQASPYLQPLTG
 2060- 2076 (26.25/ 9.17)	QRLLQMQQPQQPQQPQP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     380.52|      40|     157|    1918|    1957|       2
---------------------------------------------------------------------------
 1639- 1670 (24.63/ 6.38)	....PMGSL.........IDTK.....G.....NKIA.....GFDS..IDKKQGLQVST..KQ...................K
 1695- 1737 (31.75/10.62)	...RVDRRV.........IKYE.....EqhhllLYHTHPMPKPRSY..YLQPLPLPPEE..EE...................E
 1738- 1774 (25.12/ 6.67)	...EPTSPV.........SQEP.....E.....RKSAELSDQGKTT..TDEEKKTKGRK..RK....................
 1776- 1812 (39.19/15.05)	...KSSSRV.........DEYP.....Q......SNIYRVPPNYSP..ISSQMMHHPQS..TL...................W
 1815- 1852 (37.22/13.87)	NL.VGQPQQ.........PGF......F.....LQNQSLTPGGSRLdpAGSFVP...TN..TK...................Q
 1858- 1889 (34.61/12.32)	LQ.RRSGAM.........MQPP.....S.....LHAI............TSQQQLIQMKllQQ...................Q
 1918- 1957 (75.01/36.37)	QA.RPSPQL.........PQYP.....G.....LQQAQTMPQGYTM..YGTQMPLQQTS..QQ...................Q
 1962- 2011 (26.73/ 7.63)	VL.SPSYNS.........RAYP.....A........AHSNP..VLM..E....RLRQIQ..QQpsgyvqqqaspylqpltgsQ
 2016- 2059 (32.04/10.79)	QAlQQSPLVgggidavltSAHP.....N.....LPSV.PLPQD.PM..RPRQ.P..QVR..QQ....................
 2077- 2117 (54.21/23.99)	QQ.PPQPQQ.........SSQPqsqtlG.....LQAMQ..PQ.QPL..FPRQ.GLQQTQ..QQ...................Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     502.20|     161|     201|     874|    1074|       3
---------------------------------------------------------------------------
  874- 1072 (256.01/248.41)	SYTTGLCVCIVAVLRRyhsclilnpdqtaQVFeGLCGVVKHVVNPSECSSPerC..............ILAYLYDLYVSCsHLRSKFGDLFS...SACSKVKQTIYNNVMPANSNLRWDPDFMM..DF.IENPSARSINystlgkilsdnaanrysfvcNTLMNVcMGHQDAGRINDIANFSSELTACCTVLSSEWLG.......VLKALCCS...SNHVWGFNDVLCT
 1079- 1269 (246.19/157.73)	SFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPSLLAAA..CgdadaepgarmtcrLLLHLFRAPQAC.FLPQATGKPFPgirSSCDRHLLAAAHNSIEVGAVFAVLKAIMMlgDAkIGNNSVSSLK....................NDDFTM.RGLRCDGNADDIWTASQNPKSCGKSISIETANlreyaryVLRTICQQewvGEHCLKEPERLCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.34|      15|      20|    1364|    1381|       4
---------------------------------------------------------------------------
 1367- 1381 (25.73/20.03)	SADLNNSSNSGMSLF
 1388- 1402 (25.61/ 9.98)	SADTSSTRQNGIKTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.64|      38|     203|    1304|    1353|       7
---------------------------------------------------------------------------
 1308- 1353 (57.96/56.67)	RQHIKRILQ...NL...........EQWTLRQSWLELQLmikqcLkdpGSGSVA.EMNNLL
 1512- 1564 (52.67/24.91)	RQMMHEALQlrlNLvggmfdtvqrsTQWTTDWALLLLQI.....I...TSGTVDmHTNNEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.99|      10|     203|    1276|    1285|      10
---------------------------------------------------------------------------
 1276- 1285 (17.52/10.56)	DPVLSNMQAQ
 1483- 1492 (15.47/ 8.17)	EGLLTSLQNQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09618 with Med12 domain of Kingdom Metazoa
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