<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09603

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRVRHWGNFLWDLGAQGRGEAQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPHTNIFGRY
Length2160
PositionKinase
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.499
Instability index56.39
Isoelectric point6.56
Molecular weight241062.54
Publications
PubMed=17431167

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     376.76|      66|      66|    2019|    2084|       1
---------------------------------------------------------------------------
 1866- 1927 (79.02/34.63)	...........QKLPT.RPTYP............GVLP..TTMTGV.MGLEPssykTSVY.RQQQPAVPQGQRLRQQLQQSQGMLGQSSV
 1928- 2006 (74.42/32.16)	HQMTPSSsyglQTSQGyTPYVShvglqqhtgpagTMVPpsYSSQPYQSTHPS....TN...P....TLVDPTRHLQQRPSGYVHQQAPTY
 2008- 2077 (118.56/55.90)	HGLTSTQrfshQTLQQ.TPMIS............TMTP..MSAQGVQAGVRS....TAIL.PEQQQQQQQQQQQQQQQQQQQQQQQQQQY
 2078- 2125 (68.21/28.82)	HIRQQQQ...qQILRV.RHWGN............FLWD..LGAQG...............rGEAQQQQQQQQQQQQQQQQQ.........
 2126- 2152 (36.54/11.78)	...............................................................QQQQQQQQQQQHQQQQQQQAAPPQPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.62|      77|     612|      13|      96|       2
---------------------------------------------------------------------------
   13-   54 (33.93/23.93)	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLKRPRlGPPDVYPQDPKQKEDELTAlNVKQgfnNQPAVSGD
   55-   96 (40.21/20.31)	EHGSAKNVSFNPAKiSSNFsSIIAEKLRCNTLPDTGRRKPQV..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  629-  665 (48.54/18.88)	..........................................nqkdnfwlvtarsqsaintwftdlagtkpltqlakkvpifskkeevfgylakytvpvmraawlikmtcayyaaisetkvkkrhvdpfmewtqiitkylweqlqkmaeyyrpgpaggggcgstigplphdvevairqwdyteklamfmfqdgmldrhefltwvlecfekirpgedellklllplllrysgefvqsaylsrrlayfctrrlalqldgvsshsshvisaqstsslpttpapqpptsstpstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeatagftigrvlhtlevldshsfersdfsnsldslcnrifglgpskdgheissdddavvsllcewavsckrsgrhramvvakllekrqaeieaercgeseaadekgsiasgslsapsapifqdvllqfldtqapmltdprseserveffnlvllfcelirhdvfshnmytctlisrgdlafgaPGPRPP.SPFDDPADDPEHKEAEGSS.SSKL...EDPGLSES
  667-  706 (52.94/20.69)	DIDPSSSVLFEDME.KPDF.SLFSPTMPCEGKGSPSPEKPDV..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      17|     859|     875|       4
---------------------------------------------------------------------------
  863-  875 (24.86/21.24)	MSYHLPLVQHVQF
  880-  892 (22.52/ 7.19)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      14|      17|    1664|    1680|       5
---------------------------------------------------------------------------
 1664- 1680 (16.87/18.23)	KIAGFDsIFkkEGLQVS
 1684- 1697 (28.71/16.42)	KISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.99|      16|      18|     343|     360|       6
---------------------------------------------------------------------------
  343-  360 (26.83/18.74)	STPFSDLLM.CPQhrPLVF
  363-  379 (25.16/10.86)	SCILQTILLcCPS..ALVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.35|     109|     225|     216|     335|       7
---------------------------------------------------------------------------
  216-  335 (167.00/164.30)	GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShvISAQSTSSlPTTPAPQ
  450-  567 (169.35/128.90)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS..IASGSLSA.PSAPIFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.01|      82|     225|     745|     844|       8
---------------------------------------------------------------------------
  745-  844 (116.11/129.65)	SCSHECNQrlvvlFgvGKQRDDarhAIKKITKDIlkVLNRKGTAETDQLAP...I.vplNPGDLTFLGGEDGQKRRRNRPEAFPTaedIFAKFQH..LSHYDQHQV
  981- 1071 (136.90/97.16)	SCSHLKNK.....F..GELFSD...FCSKVKNTI..YCNVEPSESNMRWAPefmIdtleNPAAHTFTYTGLGKSLSENPANRYSF...VCNALMHvcVGHHDPDRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.14|      64|     223|    1363|    1432|       9
---------------------------------------------------------------------------
 1363- 1432 (93.74/60.29)	LQLMIKQTPNNEMNSL.LE..........NIAKATIEVFQQSAETGSSSGSTASN.MPSSSKTKPVLSSlERSGvwlvaPLI
 1434- 1461 (25.05/ 6.14)	......KLP....TSV.QG..........HVLKAAGEELEKGQHLGSSS.................................
 1586- 1658 (82.35/40.97)	LSVLINGTLAADMSSIsQGsmeenkraymNLAKKLQKELGERQ...SDSLEKVRQlLPLPKQTRDVITC.EPQG.....SLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.57|      27|     202|    1079|    1105|      12
---------------------------------------------------------------------------
 1079- 1105 (51.54/33.46)	AELTGYCKSL.....SAEWLG..VLKALCCSSNN
 1273- 1306 (41.03/25.04)	ASLDVYAKYVlrsicQQEWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.90|      54|     202|     912|     976|      13
---------------------------------------------------------------------------
  912-  976 (77.11/99.44)	SDLvgSYTTSLClCIVAVLRHYHaCLILnQDQMAqvfeglCGVVKHGMN....RSDGSSAER..C.ILAYLY
 1120- 1180 (80.79/63.08)	SDL..SFHDSLA.TFVAILIARQ.CLLL.EDLIR......CAAIPSLLNaacsEQDSEPGARltCrILLHLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      14|      15|    1328|    1342|      14
---------------------------------------------------------------------------
 1328- 1342 (22.34/14.55)	HRLLDNEDgENPQRQ
 1345- 1358 (26.58/12.77)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09603 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
2) GAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSA
4) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQ
5) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
687
627
15
1888
1735
726
674
59
2075
1886










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGILS
2) QPHTNIFGRY
3) QQQQQQQQQ
1
2151
2122
8
2160
2130