<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09603

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRVRHWGNFLWDLGAQGRGEAQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPHTNIFGRY
Length2160
PositionKinase
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.499
Instability index56.39
Isoelectric point6.56
Molecular weight241062.54
Publications
PubMed=17431167

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     376.76|      66|      66|    2019|    2084|       1
---------------------------------------------------------------------------
 1866- 1927 (79.02/34.63)	...........QKLPT.RPTYP............GVLP..TTMTGV.MGLEPssykTSVY.RQQQPAVPQGQRLRQQLQQSQGMLGQSSV
 1928- 2006 (74.42/32.16)	HQMTPSSsyglQTSQGyTPYVShvglqqhtgpagTMVPpsYSSQPYQSTHPS....TN...P....TLVDPTRHLQQRPSGYVHQQAPTY
 2008- 2077 (118.56/55.90)	HGLTSTQrfshQTLQQ.TPMIS............TMTP..MSAQGVQAGVRS....TAIL.PEQQQQQQQQQQQQQQQQQQQQQQQQQQY
 2078- 2125 (68.21/28.82)	HIRQQQQ...qQILRV.RHWGN............FLWD..LGAQG...............rGEAQQQQQQQQQQQQQQQQQ.........
 2126- 2152 (36.54/11.78)	...............................................................QQQQQQQQQQQHQQQQQQQAAPPQPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.62|      77|     612|      13|      96|       2
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   13-   54 (33.93/23.93)	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLKRPRlGPPDVYPQDPKQKEDELTAlNVKQgfnNQPAVSGD
   55-   96 (40.21/20.31)	EHGSAKNVSFNPAKiSSNFsSIIAEKLRCNTLPDTGRRKPQV..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  629-  665 (48.54/18.88)	..........................................nqkdnfwlvtarsqsaintwftdlagtkpltqlakkvpifskkeevfgylakytvpvmraawlikmtcayyaaisetkvkkrhvdpfmewtqiitkylweqlqkmaeyyrpgpaggggcgstigplphdvevairqwdyteklamfmfqdgmldrhefltwvlecfekirpgedellklllplllrysgefvqsaylsrrlayfctrrlalqldgvsshsshvisaqstsslpttpapqpptsstpstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeatagftigrvlhtlevldshsfersdfsnsldslcnrifglgpskdgheissdddavvsllcewavsckrsgrhramvvakllekrqaeieaercgeseaadekgsiasgslsapsapifqdvllqfldtqapmltdprseserveffnlvllfcelirhdvfshnmytctlisrgdlafgaPGPRPP.SPFDDPADDPEHKEAEGSS.SSKL...EDPGLSES
  667-  706 (52.94/20.69)	DIDPSSSVLFEDME.KPDF.SLFSPTMPCEGKGSPSPEKPDV..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      17|     859|     875|       4
---------------------------------------------------------------------------
  863-  875 (24.86/21.24)	MSYHLPLVQHVQF
  880-  892 (22.52/ 7.19)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      14|      17|    1664|    1680|       5
---------------------------------------------------------------------------
 1664- 1680 (16.87/18.23)	KIAGFDsIFkkEGLQVS
 1684- 1697 (28.71/16.42)	KISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.99|      16|      18|     343|     360|       6
---------------------------------------------------------------------------
  343-  360 (26.83/18.74)	STPFSDLLM.CPQhrPLVF
  363-  379 (25.16/10.86)	SCILQTILLcCPS..ALVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.35|     109|     225|     216|     335|       7
---------------------------------------------------------------------------
  216-  335 (167.00/164.30)	GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShvISAQSTSSlPTTPAPQ
  450-  567 (169.35/128.90)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS..IASGSLSA.PSAPIFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.01|      82|     225|     745|     844|       8
---------------------------------------------------------------------------
  745-  844 (116.11/129.65)	SCSHECNQrlvvlFgvGKQRDDarhAIKKITKDIlkVLNRKGTAETDQLAP...I.vplNPGDLTFLGGEDGQKRRRNRPEAFPTaedIFAKFQH..LSHYDQHQV
  981- 1071 (136.90/97.16)	SCSHLKNK.....F..GELFSD...FCSKVKNTI..YCNVEPSESNMRWAPefmIdtleNPAAHTFTYTGLGKSLSENPANRYSF...VCNALMHvcVGHHDPDRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.14|      64|     223|    1363|    1432|       9
---------------------------------------------------------------------------
 1363- 1432 (93.74/60.29)	LQLMIKQTPNNEMNSL.LE..........NIAKATIEVFQQSAETGSSSGSTASN.MPSSSKTKPVLSSlERSGvwlvaPLI
 1434- 1461 (25.05/ 6.14)	......KLP....TSV.QG..........HVLKAAGEELEKGQHLGSSS.................................
 1586- 1658 (82.35/40.97)	LSVLINGTLAADMSSIsQGsmeenkraymNLAKKLQKELGERQ...SDSLEKVRQlLPLPKQTRDVITC.EPQG.....SLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.57|      27|     202|    1079|    1105|      12
---------------------------------------------------------------------------
 1079- 1105 (51.54/33.46)	AELTGYCKSL.....SAEWLG..VLKALCCSSNN
 1273- 1306 (41.03/25.04)	ASLDVYAKYVlrsicQQEWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.90|      54|     202|     912|     976|      13
---------------------------------------------------------------------------
  912-  976 (77.11/99.44)	SDLvgSYTTSLClCIVAVLRHYHaCLILnQDQMAqvfeglCGVVKHGMN....RSDGSSAER..C.ILAYLY
 1120- 1180 (80.79/63.08)	SDL..SFHDSLA.TFVAILIARQ.CLLL.EDLIR......CAAIPSLLNaacsEQDSEPGARltCrILLHLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      14|      15|    1328|    1342|      14
---------------------------------------------------------------------------
 1328- 1342 (22.34/14.55)	HRLLDNEDgENPQRQ
 1345- 1358 (26.58/12.77)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09603 with Med12 domain of Kingdom Metazoa
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