<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09599

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKITRGMRQAALHTLSPDSLSPPSLQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRLPRLNEAQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPHTNIFGRY
Length2147
PositionKinase
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.492
Instability index56.33
Isoelectric point6.64
Molecular weight239598.20
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09599
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.17|      15|      15|    2051|    2065|       1
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 2051- 2065 (36.16/16.09)	QQQQ..........QQQQQQQQ.QQQ
 2067- 2082 (29.40/11.75)	QQQQ..........QQQQQQYHiRQQ
 2083- 2107 (28.16/10.95)	QQQQilrlprlneaQQQQQQQQ.QQQ
 2108- 2122 (36.16/16.09)	QQQQ..........QQQQQQQQ.QQQ
 2123- 2136 (25.30/ 9.12)	QHQQ..........QQQQQAAP.PQ.
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.16|      35|     338|     667|     704|       2
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  667-  704 (63.46/42.19)	DIDPSSSvlfEDME.KPDF...SLFSP...TMPCEGKGSPSPEKP
 1007- 1047 (44.80/22.38)	NVEPSES....NMRwAPEFmidTLENPaahTFTYTGLGKSLSENP
 1747- 1768 (27.90/10.11)	..........EDEE.PPAP...TLLEP...E.....KKAPEPPK.
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     310.67|     102|     338|     160|     266|       3
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  160-  215 (55.21/51.20)	..............................................................IKMTCAYyaAISeTKVKKRHVDpfMEWTQIITKYLWE.QLQKMAEYYRPGPAGGGGC
  216-  266 (68.09/40.80)	GSTIGP.LPHDVEV....AIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIR...............................................................
  450-  555 (138.12/94.96)	GFTIGR.VLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISsdddavVSLLCEW..AVS.CKRSGRHRA..MVVAKLLEKRQAEiEAERCGESEAADEKGSIAS
  556-  605 (49.24/26.62)	GSLSAPsAPIFQDV....LLQFLD..TQAPMLTDPRSESERVEFFNLVLLFCELIR...............................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      22|     612|      13|      35|       4
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   13-   35 (40.01/22.17)	PLKRPRlGPPDVYPQDPKQKEDE
  629-  650 (45.34/21.78)	PGPRPP.SPFDDPADDPEHKEAE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     633.52|     185|     199|    1176|    1374|       5
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 1064- 1166 (91.44/40.65)	...............................................................................................GHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNngtcgfndllcnvDVSDLSFHDSLATFVAILIA......................RQCL..LLEDLIRCAAIPSLLNAAC...SE....QDSE
 1176- 1374 (290.66/185.84)	LL........HLFKtpQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRivdGAVFAVLKavfVLgdAELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSN.............DLQDPVLSSAQAQRLMQLICYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMRQSSLELQLMIKQT....PNNE
 1378- 1577 (251.41/132.49)	LLeniakatiEVFQ..QSAETGSSSGSTASNMPSSSKTKPVLSSLER...SGVWLVAP...LI..AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVH.............QI...VNNWRDDQYLDD..CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAM....LLLEIIISGTvdmqSNNE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.01|      16|      18|    1956|    1971|       6
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 1956- 1971 (32.69/14.89)	HTGPAGTMVPPSYSSQ
 2004- 2019 (22.32/ 7.83)	PTYGHGLTSTQRFSHQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      18|    1663|    1680|       7
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 1663- 1680 (18.50/19.77)	NKIAGFDsIFkkEGLQVS
 1683- 1697 (30.32/17.93)	QKISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.39|      24|     199|    1713|    1744|       8
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 1713- 1744 (29.61/34.80)	RVARGEEQQRLllyHThLRPRPrayyLEPLPL
 1918- 1941 (43.78/22.56)	KITRGMRQAAL...HT.LSPDS....LSPPSL
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.50|      24|      53|    1818|    1854|       9
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 1818- 1847 (41.93/25.83)	PDLLHHPN.PG....SIThlnyrqGSIGL.........YTQNQP
 1866- 1903 (30.58/15.29)	QKLPTRPTyPGvlptTMT......GVMGLepssyktsvYRQQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      18|     859|     875|      10
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  863-  875 (24.86/20.98)	MSYHLPLVQHVQF
  880-  892 (22.52/ 7.19)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.99|      16|      18|     346|     363|      11
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  346-  363 (25.84/20.02)	FSDLLM.CPQhrPLVFGLS
  366-  382 (25.15/12.09)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.75|      13|      45|    1803|    1817|      12
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 1803- 1817 (19.48/17.84)	GmGPgRSGPY.GVTVP
 1851- 1864 (24.27/11.14)	G.GP.RVDPYrPVRLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     663|     122|     135|      17
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  122-  135 (24.94/12.88)	GTKPLTQLAKKVPI
  786-  799 (25.11/13.02)	GTAETDQLAPIVPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09599 with Med12 domain of Kingdom Metazoa
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