<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09599

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKITRGMRQAALHTLSPDSLSPPSLQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRLPRLNEAQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPHTNIFGRY
Length2147
PositionKinase
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.492
Instability index56.33
Isoelectric point6.64
Molecular weight239598.20
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09599
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.17|      15|      15|    2051|    2065|       1
---------------------------------------------------------------------------
 2051- 2065 (36.16/16.09)	QQQQ..........QQQQQQQQ.QQQ
 2067- 2082 (29.40/11.75)	QQQQ..........QQQQQQYHiRQQ
 2083- 2107 (28.16/10.95)	QQQQilrlprlneaQQQQQQQQ.QQQ
 2108- 2122 (36.16/16.09)	QQQQ..........QQQQQQQQ.QQQ
 2123- 2136 (25.30/ 9.12)	QHQQ..........QQQQQAAP.PQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.16|      35|     338|     667|     704|       2
---------------------------------------------------------------------------
  667-  704 (63.46/42.19)	DIDPSSSvlfEDME.KPDF...SLFSP...TMPCEGKGSPSPEKP
 1007- 1047 (44.80/22.38)	NVEPSES....NMRwAPEFmidTLENPaahTFTYTGLGKSLSENP
 1747- 1768 (27.90/10.11)	..........EDEE.PPAP...TLLEP...E.....KKAPEPPK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     310.67|     102|     338|     160|     266|       3
---------------------------------------------------------------------------
  160-  215 (55.21/51.20)	..............................................................IKMTCAYyaAISeTKVKKRHVDpfMEWTQIITKYLWE.QLQKMAEYYRPGPAGGGGC
  216-  266 (68.09/40.80)	GSTIGP.LPHDVEV....AIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIR...............................................................
  450-  555 (138.12/94.96)	GFTIGR.VLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISsdddavVSLLCEW..AVS.CKRSGRHRA..MVVAKLLEKRQAEiEAERCGESEAADEKGSIAS
  556-  605 (49.24/26.62)	GSLSAPsAPIFQDV....LLQFLD..TQAPMLTDPRSESERVEFFNLVLLFCELIR...............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      22|     612|      13|      35|       4
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   13-   35 (40.01/22.17)	PLKRPRlGPPDVYPQDPKQKEDE
  629-  650 (45.34/21.78)	PGPRPP.SPFDDPADDPEHKEAE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     633.52|     185|     199|    1176|    1374|       5
---------------------------------------------------------------------------
 1064- 1166 (91.44/40.65)	...............................................................................................GHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNngtcgfndllcnvDVSDLSFHDSLATFVAILIA......................RQCL..LLEDLIRCAAIPSLLNAAC...SE....QDSE
 1176- 1374 (290.66/185.84)	LL........HLFKtpQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRivdGAVFAVLKavfVLgdAELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSN.............DLQDPVLSSAQAQRLMQLICYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMRQSSLELQLMIKQT....PNNE
 1378- 1577 (251.41/132.49)	LLeniakatiEVFQ..QSAETGSSSGSTASNMPSSSKTKPVLSSLER...SGVWLVAP...LI..AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVH.............QI...VNNWRDDQYLDD..CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAM....LLLEIIISGTvdmqSNNE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.01|      16|      18|    1956|    1971|       6
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 1956- 1971 (32.69/14.89)	HTGPAGTMVPPSYSSQ
 2004- 2019 (22.32/ 7.83)	PTYGHGLTSTQRFSHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      18|    1663|    1680|       7
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 1663- 1680 (18.50/19.77)	NKIAGFDsIFkkEGLQVS
 1683- 1697 (30.32/17.93)	QKISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.39|      24|     199|    1713|    1744|       8
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 1713- 1744 (29.61/34.80)	RVARGEEQQRLllyHThLRPRPrayyLEPLPL
 1918- 1941 (43.78/22.56)	KITRGMRQAAL...HT.LSPDS....LSPPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.50|      24|      53|    1818|    1854|       9
---------------------------------------------------------------------------
 1818- 1847 (41.93/25.83)	PDLLHHPN.PG....SIThlnyrqGSIGL.........YTQNQP
 1866- 1903 (30.58/15.29)	QKLPTRPTyPGvlptTMT......GVMGLepssyktsvYRQQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      18|     859|     875|      10
---------------------------------------------------------------------------
  863-  875 (24.86/20.98)	MSYHLPLVQHVQF
  880-  892 (22.52/ 7.19)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.99|      16|      18|     346|     363|      11
---------------------------------------------------------------------------
  346-  363 (25.84/20.02)	FSDLLM.CPQhrPLVFGLS
  366-  382 (25.15/12.09)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.75|      13|      45|    1803|    1817|      12
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 1803- 1817 (19.48/17.84)	GmGPgRSGPY.GVTVP
 1851- 1864 (24.27/11.14)	G.GP.RVDPYrPVRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     663|     122|     135|      17
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  122-  135 (24.94/12.88)	GTKPLTQLAKKVPI
  786-  799 (25.11/13.02)	GTAETDQLAPIVPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09599 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
2) GAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSA
4) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKITRGMRQAALHTLSPDSLSPPSLQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQ
5) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
687
627
15
1888
1735
726
674
59
2075
1886










Molecular Recognition Features






MoRF SequenceStartStop




1) ILRLPRLN
2) MAAFGIL
3) QPHTNIFGRY
4) QQQQQQQQQQ
2087
1
2138
2109
2094
7
2147
2118