<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09592
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSDHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQVRCPRRGPAPHLGPDSWPRPSSGP |
Length | 659 |
Position | Tail |
Organism | Macaca mulatta (Rhesus macaque) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Macaca.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.037 |
Instability index | 43.88 |
Isoelectric point | 7.26 |
Molecular weight | 72772.48 |
Publications | PubMed=17431167
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | catalytic activity GO:0003824 IEA:InterPro
|
GO - Biological Process | |
Interaction
Repeat regions
Repeats |
>MDP09592
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 322.40| 104| 200| 1| 136| 1
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22- 136 (177.25/175.75) EKWSKSTHCPSVPLACAWSCRNLIAFTMD.......LRSDDQDLTrmihilDTEHPWDLHsipSDHREAITCLEW...DQSGSRLL..SADADGQIKCWSM.ADHL.ANSWESSVGSLVeGD..PIVaLSW
157- 233 (93.72/48.17) EKFSRVKFSPSLTLFGGKPMEGWIAVTVSglvtvslLKPSGQVLT......STESLCRLR...G..RVALADIAF....TGGGNIV..VATADG.....................................
275- 339 (51.43/19.47) ................................................................DKFPAITHLKFlarDMSEQVLLcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVV.GDkqPTI.LKW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.99| 30| 49| 533| 563| 5
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533- 563 (47.57/39.35) LC.KLSPCTVTRV.CDYHTKLFLIAIsSTLKSL
583- 614 (40.42/27.83) ICaKITDVDIDKVmINLKTEEFVLDM.NTLQAL
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