<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09589

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIVRGAVGRGYTPYVSHVGLQQHTGPPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2150
PositionKinase
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.508
Instability index56.75
Isoelectric point6.76
Molecular weight240197.71
Publications
PubMed=17431167

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09589
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.45|      15|      15|    2023|    2037|       1
---------------------------------------------------------------------------
 2023- 2037 (34.96/11.59)	QQQQQQQQQ....QQQQQQ
 2040- 2058 (29.36/ 8.67)	QQQQQQQQQyhirQQQQQQ
 2062- 2075 (33.24/10.70)	QQQQQQQQQ....QQQQ.Q
 2076- 2090 (34.57/11.39)	QQQQQQQQQ....QQQQHQ
 2091- 2105 (31.33/ 9.70)	QQQQQQAAP....PQPQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.16|      35|     338|     667|     704|       2
---------------------------------------------------------------------------
  667-  704 (63.46/47.87)	DIDPSSSvlfEDME.KPDF...SLFSP...TMPCEGKGSPSPEKP
 1007- 1047 (44.80/25.37)	NVEPSES....NMRwAPEFmidTLENPaahTFTYTGLGKSLSENP
 1747- 1768 (27.90/11.46)	..........EDEE.PPAP...TLLEP...E.....KKAPEPPK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     310.67|     102|     338|     160|     266|       3
---------------------------------------------------------------------------
  160-  215 (55.21/45.30)	..............................................................IKMTCAYyaAISeTKVKKRHVDpfMEWTQIITKYLWE.QLQKMAEYYRPGPAGGGGC
  216-  266 (68.09/36.12)	GSTIGP.LPHDVEV....AIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIR...............................................................
  450-  555 (138.12/83.97)	GFTIGR.VLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISsdddavVSLLCEW..AVS.CKRSGRHRA..MVVAKLLEKRQAEiEAERCGESEAADEKGSIAS
  556-  605 (49.24/23.60)	GSLSAPsAPIFQDV....LLQFLD..TQAPMLTDPRSESERVEFFNLVLLFCELIR...............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      22|     613|      13|      35|       4
---------------------------------------------------------------------------
   13-   35 (40.01/18.34)	PLKRPRlGPPDVYPQDPKQKEDE
  629-  650 (45.34/18.02)	PGPRPP.SPFDDPADDPEHKEAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.82|      48|     613|    1247|    1300|       5
---------------------------------------------------------------------------
 1064- 1099 (45.68/23.15)	.......GHHDPDRvnDIAILCAEL.TGYCKSL.....SAEWLG.....V..LKAL
 1102- 1155 (63.85/33.37)	SSNNGTCGFNDLLC..NVDVSDLSFhDSLATFVAILIARQCLLLEdliRCaaIPSL
 1253- 1300 (85.29/61.12)	EGGGGSGGRRQGGR..NISVETASL.DVYAKYVLRSICQQEWVGE...RC..LKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     121.16|      28|      29|    1794|    1821|       6
---------------------------------------------------------------------------
 1794- 1817 (40.74/18.71)	.......QPAAK......TEDY.......GMGPG..RSGPY...GVTVP
 1846- 1864 (22.95/ 7.13)	.......QPLPA.................G.GP...RVDPY..rPVRLP
 1875- 1906 (32.65/13.45)	P.GVL...PTTM......TGVM.......GLEPSsyKTSVYrqqQPAVP
 1907- 1950 (24.81/ 8.34)	QgQRLrqQLQAKivrgavGRGYtpyvshvGLQQH..TGPPY...QSTHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.90|      31|     613|    1495|    1526|       7
---------------------------------------------------------------------------
 1495- 1526 (51.00/33.47)	QREGLLTSLySQVHQIVNNWRDDQYLDDCKPK
 1631- 1654 (31.45/14.62)	.......SL.EKVRQLLPLPKQTRDVITCEPQ
 1673- 1696 (36.45/18.17)	KKEGLQVS....TKQKISPW..DLF.EGLKP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     853|     867|       8
---------------------------------------------------------------------------
  853-  867 (26.85/16.24)	LEQITSFALG.MSYHL
  869-  884 (23.14/13.01)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.47|      41|     609|    1389|    1436|       9
---------------------------------------------------------------------------
 1339- 1400 (51.67/45.50)	PQRQRIKRILQNLDqwtmRQSSLELQLMIKQTPnnemnslleniakatieVFQQSAETGSSS
 1408- 1461 (58.80/34.77)	PSSSKTKPVLSSLE....RSGVWLVAPLIAKLP....tsvqghvlkaageELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.96|      16|      18|    2109|    2124|      11
---------------------------------------------------------------------------
 1986- 2001 (24.40/ 9.90)	QrFSHQTLQQT.PMIST
 2109- 2124 (31.83/15.66)	Q.FQRQGLQQTQQQQQT
 2130- 2144 (27.73/12.49)	Q.LQQQ.LSNTQPQPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.99|      16|      18|     346|     363|      12
---------------------------------------------------------------------------
  346-  363 (25.84/15.69)	FSDLLM.CPQhrPLVFGLS
  366-  382 (25.15/ 9.43)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1561|    1574|      14
---------------------------------------------------------------------------
 1561- 1574 (24.50/18.76)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/13.97)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09589 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
2) GAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSA
4) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIV
5) PYVSHVGLQQHTGPPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQ
6) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
687
627
15
1888
1930
1735
726
674
59
1920
2032
1886










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGI
2) NIFGRY
1
2145
6
2150