<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09589

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIVRGAVGRGYTPYVSHVGLQQHTGPPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2150
PositionKinase
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.508
Instability index56.75
Isoelectric point6.76
Molecular weight240197.71
Publications
PubMed=17431167

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09589
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.45|      15|      15|    2023|    2037|       1
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 2023- 2037 (34.96/11.59)	QQQQQQQQQ....QQQQQQ
 2040- 2058 (29.36/ 8.67)	QQQQQQQQQyhirQQQQQQ
 2062- 2075 (33.24/10.70)	QQQQQQQQQ....QQQQ.Q
 2076- 2090 (34.57/11.39)	QQQQQQQQQ....QQQQHQ
 2091- 2105 (31.33/ 9.70)	QQQQQQAAP....PQPQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.16|      35|     338|     667|     704|       2
---------------------------------------------------------------------------
  667-  704 (63.46/47.87)	DIDPSSSvlfEDME.KPDF...SLFSP...TMPCEGKGSPSPEKP
 1007- 1047 (44.80/25.37)	NVEPSES....NMRwAPEFmidTLENPaahTFTYTGLGKSLSENP
 1747- 1768 (27.90/11.46)	..........EDEE.PPAP...TLLEP...E.....KKAPEPPK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     310.67|     102|     338|     160|     266|       3
---------------------------------------------------------------------------
  160-  215 (55.21/45.30)	..............................................................IKMTCAYyaAISeTKVKKRHVDpfMEWTQIITKYLWE.QLQKMAEYYRPGPAGGGGC
  216-  266 (68.09/36.12)	GSTIGP.LPHDVEV....AIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIR...............................................................
  450-  555 (138.12/83.97)	GFTIGR.VLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISsdddavVSLLCEW..AVS.CKRSGRHRA..MVVAKLLEKRQAEiEAERCGESEAADEKGSIAS
  556-  605 (49.24/23.60)	GSLSAPsAPIFQDV....LLQFLD..TQAPMLTDPRSESERVEFFNLVLLFCELIR...............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      22|     613|      13|      35|       4
---------------------------------------------------------------------------
   13-   35 (40.01/18.34)	PLKRPRlGPPDVYPQDPKQKEDE
  629-  650 (45.34/18.02)	PGPRPP.SPFDDPADDPEHKEAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.82|      48|     613|    1247|    1300|       5
---------------------------------------------------------------------------
 1064- 1099 (45.68/23.15)	.......GHHDPDRvnDIAILCAEL.TGYCKSL.....SAEWLG.....V..LKAL
 1102- 1155 (63.85/33.37)	SSNNGTCGFNDLLC..NVDVSDLSFhDSLATFVAILIARQCLLLEdliRCaaIPSL
 1253- 1300 (85.29/61.12)	EGGGGSGGRRQGGR..NISVETASL.DVYAKYVLRSICQQEWVGE...RC..LKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     121.16|      28|      29|    1794|    1821|       6
---------------------------------------------------------------------------
 1794- 1817 (40.74/18.71)	.......QPAAK......TEDY.......GMGPG..RSGPY...GVTVP
 1846- 1864 (22.95/ 7.13)	.......QPLPA.................G.GP...RVDPY..rPVRLP
 1875- 1906 (32.65/13.45)	P.GVL...PTTM......TGVM.......GLEPSsyKTSVYrqqQPAVP
 1907- 1950 (24.81/ 8.34)	QgQRLrqQLQAKivrgavGRGYtpyvshvGLQQH..TGPPY...QSTHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.90|      31|     613|    1495|    1526|       7
---------------------------------------------------------------------------
 1495- 1526 (51.00/33.47)	QREGLLTSLySQVHQIVNNWRDDQYLDDCKPK
 1631- 1654 (31.45/14.62)	.......SL.EKVRQLLPLPKQTRDVITCEPQ
 1673- 1696 (36.45/18.17)	KKEGLQVS....TKQKISPW..DLF.EGLKP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     853|     867|       8
---------------------------------------------------------------------------
  853-  867 (26.85/16.24)	LEQITSFALG.MSYHL
  869-  884 (23.14/13.01)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.47|      41|     609|    1389|    1436|       9
---------------------------------------------------------------------------
 1339- 1400 (51.67/45.50)	PQRQRIKRILQNLDqwtmRQSSLELQLMIKQTPnnemnslleniakatieVFQQSAETGSSS
 1408- 1461 (58.80/34.77)	PSSSKTKPVLSSLE....RSGVWLVAPLIAKLP....tsvqghvlkaageELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.96|      16|      18|    2109|    2124|      11
---------------------------------------------------------------------------
 1986- 2001 (24.40/ 9.90)	QrFSHQTLQQT.PMIST
 2109- 2124 (31.83/15.66)	Q.FQRQGLQQTQQQQQT
 2130- 2144 (27.73/12.49)	Q.LQQQ.LSNTQPQPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.99|      16|      18|     346|     363|      12
---------------------------------------------------------------------------
  346-  363 (25.84/15.69)	FSDLLM.CPQhrPLVFGLS
  366-  382 (25.15/ 9.43)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1561|    1574|      14
---------------------------------------------------------------------------
 1561- 1574 (24.50/18.76)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/13.97)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09589 with Med12 domain of Kingdom Metazoa
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