<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09570

Description Mediator complex subunit 12
SequenceMRLMVGSTDGILSMLRRSLSYEIQFILFFFPFLLQISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIEWTQIITKYLSEQLQKIAEFYRQLPGQSCGSPAGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSTQTGNALPSTPTPQPATGNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEDTGLSEPMDIDHNSSTIFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKPLLKDKSAEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTANNEMNSLLENIAKATIEVFQQSAETSSASSAGNGVNNISSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRRVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEPEKKAVEPSKADKTSSNPATSTEERKKKQSKTKKRNQSASKSEDFVLGPSRGVSYGVGMPTDLLHHQAGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPSGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQTVRQMAPTPSYGALQPSQGYTPYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQSFQS
Length1978
PositionKinase
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.07
Grand average of hydropathy-0.365
Instability index51.98
Isoelectric point6.47
Molecular weight220630.02
Publications
PubMed=15592404

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09570
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     417.06|     130|     210|    1608|    1752|       1
---------------------------------------------------------------------------
 1608- 1752 (204.14/199.60)	PQGSLIDTK....GNKIAGFDSIFkkeGLQVSTKQKIspwdlfegLKHSAPLSWGWFGTVRVDRRV..SRFEEQQRLllyhTHLKPKPRSYYLEP....LPLPPE...EEEPPTPVALEPEKKAVEPSKADKTSSNPATSTEERKKKQSKTKKRNQSA
 1821- 1963 (212.92/166.35)	PLGKLVQSRppysGVLPSGMGSMM...GIDPSYKPAV........YRQQPPVSQGQILRQQLQAKLqgQGIMGQQTV....RQMAPTPSYGALQPsqgyTPYVSHiglQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     260.97|      81|     216|      11|      96|       2
---------------------------------------------------------------------------
   11-   96 (134.78/102.85)	ILSMLRRSLSYEIQFILFFFPFLLQISSNF..SSIIAEKLR..CN.....TLPDTGRRKPQV..NQKDNFWLVTARSQSAINNwftdlAGTKPLTHL
  224-  315 (126.19/83.79)	VLECFEKIRSGEDEFLKMLLPLLLRYSGEFvqSAYLSRRLAyfCTrrlamQLDGAGGHPPHIlsTQTGNALPSTPTPQPATGN.....PPPSPFSDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.11|      55|     216|    1144|    1268|       3
---------------------------------------------------------------------------
  401-  457 (92.48/35.32)	VEVRWSFDK.....CQETTAGFTIGRVLHTLEVLDSHSFERSDFSN..SLDSLYNRifGLGPTK
 1147- 1208 (82.62/138.00)	VGIRSSCDRhllaaSQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHpgGVDDLMDD..ELGTRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.62|      22|     216|    1228|    1268|       4
---------------------------------------------------------------------------
 1031- 1055 (38.97/14.85)	LTGYCKSlsaEWLG..VLKALCCSSNN
 1229- 1252 (39.65/51.87)	LRSICQQ...EWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.24|      21|      23|    1507|    1529|       9
---------------------------------------------------------------------------
 1507- 1529 (30.70/29.41)	QQTTewAVL.LLDIISSGTV..DMQS
 1532- 1555 (26.54/16.27)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09570 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPPMHCESKASPSPEKPDPEKEAKPLLKDKSAEGMLASLY
2) GVGMPTDLLHHQAGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSG
3) IDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQTVRQMAPTPSYGALQPS
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
5) LAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEDTGLSE
6) PYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQREHVYSASSPEK
7) SYYLEPLPLPPEEEEPPTPVALEPEKKAVEPSKADKTSSNPATSTEERKKKQSKTKKRNQSASKSEDFVLGPSRG
769
1885
1962
98
706
2022
1807
809
1950
2017
147
746
2102
1881










Molecular Recognition Features






MoRF SequenceStartStop




NANANA