<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09569

Description Mediator complex subunit 12
SequenceMRLMVGSTDGILSMLRRSLSYEIQFILFFFPFLLQISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIEWTQIITKYLSEQLQKIAEFYRQLPGQSCGSPAGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSTQTGNALPSTPTPQPATGNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEDTGLSEPMDIDHNSSTIFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKPLLKDKSAEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTANNEMNSLLENIAKATIEVFQQSAETSSASSAGNGVNNISSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRRVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEPEKKAVEPSKADKTSSNPATSTEERKKKQSKTKKRNQSASKSEDFVLGPSRGVSYGVGMPTDLLHHQAGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPSGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQTVRQMAPTPSYGALQPSQGYTPYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQRFPHQSIQQAPMMTGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQQQMLRVSGC
Length2033
PositionKinase
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.07
Grand average of hydropathy-0.383
Instability index52.78
Isoelectric point6.61
Molecular weight226932.18
Publications
PubMed=15592404

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09569
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     567.46|     176|     210|    1608|    1805|       1
---------------------------------------------------------------------------
 1608- 1805 (269.15/204.48)	PQGSLIDTK....GNKIAGFDSIFkkeGLQVSTKQKIspwdlfegLKHSAPLSWGWFGTVRVDRRV..SRFEEQQRLllyhTHLKPKPRSYYLEP....LPLPPE...EEEPPTPVALEPEKKAVEPSKADKTSSNPATSTEERKKKQSKTKKRNQSAsKSEDFVLGPSRGVSYGVGMPTDLLhhqagSTMSRLAYGQSPVGLYaQNQPLP
 1821- 2009 (298.30/174.96)	PLGKLVQSRppysGVLPSGMGSMM...GIDPSYKPAV........YRQQPPVSQGQILRQQLQAKLqgQGIMGQQTV....RQMAPTPSYGALQPsqgyTPYVSHiglQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQA.PGYGHTLGNTQRFPHQSIQQAPMM.....TGMNHLGPQGVPSGIR.PSQILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     260.97|      81|     216|      11|      96|       2
---------------------------------------------------------------------------
   11-   96 (134.78/98.98)	ILSMLRRSLSYEIQFILFFFPFLLQISSNF..SSIIAEKLR..CN.....TLPDTGRRKPQV..NQKDNFWLVTARSQSAINNwftdlAGTKPLTHL
  224-  315 (126.19/80.62)	VLECFEKIRSGEDEFLKMLLPLLLRYSGEFvqSAYLSRRLAyfCTrrlamQLDGAGGHPPHIlsTQTGNALPSTPTPQPATGN.....PPPSPFSDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.11|      55|     216|    1144|    1268|       3
---------------------------------------------------------------------------
  401-  457 (92.48/32.96)	VEVRWSFDK.....CQETTAGFTIGRVLHTLEVLDSHSFERSDFSN..SLDSLYNRifGLGPTK
 1147- 1208 (82.62/129.09)	VGIRSSCDRhllaaSQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHpgGVDDLMDD..ELGTRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.62|      22|     216|    1228|    1268|       4
---------------------------------------------------------------------------
 1031- 1055 (38.97/14.26)	LTGYCKSlsaEWLG..VLKALCCSSNN
 1229- 1252 (39.65/50.01)	LRSICQQ...EWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.48|      84|     161|    1354|    1443|       9
---------------------------------------------------------------------------
 1354- 1443 (129.80/126.94)	NISSSASATPASNkSKPILSSLERSGVWLVAPLIAKLPTSVQGHVlkaagEELEKG.QHLGSSSRKE.RDRQK...QKSMSLLSQQPFLSLVLTC
 1518- 1606 (125.68/104.54)	DIISSGTVDMQSN.NELFTTVLDMLSVLINGTLAADMSSISQGSM.....EENKRAyMNLVKKLRKElGDRQSdslEKVRQLLPLPKQTRDVITC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.74|      18|     551|    1448|    1465|      15
---------------------------------------------------------------------------
  682-  699 (33.70/24.00)	DKSAEGMLASLYDQPRHI
 1448- 1465 (32.03/22.38)	DEQREGLLTSLYSQVQQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09569 with Med12 domain of Kingdom Metazoa
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