Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MPSDESSDIGLYYVDFNRNFQKCNACPLDNLIESFGLSDIAASVARTKPNGEKAVKLRKSYKSHINDLPYKHTIKSDNILESIALREDITLGLNDLSNFIKPIDRDLVSRALNFKKTPKDSLNDIEIEDLQFKTIVDFDKKSLKRKQKNGYTNDDDLKRRRM |
Length | 162 |
Position | Head |
Organism | Ascoidea rubescens DSM 1968 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Ascoideaceae> Ascoidea. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.746 |
Instability index | 45.72 |
Isoelectric point | 8.75 |
Molecular weight | 18643.95 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP09556 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 73.69| 23| 26| 55| 79| 1 --------------------------------------------------------------------------- 55- 77 (39.95/29.11) VKLRKSYKSHINDLP.YKHTIKSD 83- 106 (33.73/17.30) IALREDITLGLNDLSnFIKPIDRD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.68| 14| 28| 115| 131| 2 --------------------------------------------------------------------------- 115- 131 (18.75/14.31) KKTPKDSLNDieiEDLQ 145- 158 (24.93/11.66) RKQKNGYTND...DDLK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DIEIEDLQFKTIVDFDKKSLK 2) DIGLYYVDFNR 3) DLKRR 4) VKLRKSYKSHINDLPY | 124 8 156 55 | 144 18 160 70 |
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