<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09544

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSFSPPDNPDIYSLLNQNYQNKISWSNNGVIAYSNPDSSNKYNLLLSYLRSYNGNQWELAPPKGCSIINSNLNNNSNIKNIIKNNTKNNIKTNNNNNNIIISNAIPIDTQNNSSLDQISYLLWSNNGTYLACVDSKGNMNILVSGILKDKDFIENNNSNTSNNKNKTNTPLNFAFFGSCFNSLEIIYQDTVLTQGSTPPENSYLNTSHNIYPSNTSIPTFDNYCSTYNINDSTLNIVSLKWLPIDHNFMAIKYAEKFNFSENMNANAEYDFQKFGFKYNYINSTYKNPVTHPVLKKHACIGLRKNGELILWYQGDHGLDYNKISTYLDSSSATTTNNSINNINNISNINYKSINSLNNSGHTIISHADFAFQINNSILLTVYCPLIKILKIYSIRILWEFLGNPNNQTKNQSAYQQDNNLDERFPPKLIVKKILSENISSFGFDGSSQWLSSIKSISPVYFEDNTNSNEKVDIFLTFQNSNLNEKFNTLICKYHLEKKKLGPISNVFYQISNNLKNNTNKNINDTGNNNNMNTNIKNTRNNNNTIITNSNISGYELSLKSLIKSSSPVLSIGTNKINSFLYFAYSNGNIEIRNKHSLKIIGYKTLLENPANNVNKRNVINNDILNMPSTIGNIFDVGYKLPSVGFNPLFYSFSPNVTSYVVLSSKDPNLKLFVANFDFKKELLNSPRQRLLIAVPIAISFARCTTTKINSDDLILVAQNTITNIRRMVALHYNPKTDSNICKALISIILLECYWIFNFSLTTNDNAEFIQGKSPFRKMLEIQISLGTFENWRRIKISRFAWALINLSLIPFVFQISFNAITTMLKKLHGGDEKNIKTNVELIAKLILSQVGLIRWCIDYVTFLNQQLLQFSLVFDKATALSELLIFPLLYSRIPRTFLIKILKSILQFKRFLQEHIHLNPDYFNISPGLFVELEQPINSAKSTVLRIIDNSPIDLALFEKYLEQFDEFIKKFISDRINERINASNLSNLSADKRKHIEDIEIKKIEKEFFCHGSFPQIFSKIILDLYKYGYKEVHGKMNRYKLMFYDTDWLNLSEPSNHRVEIGSFRGEKIDGLKKTLILNTLPNEEIKKCTRCGSMTVFSDKLGSHSGKAFRNPTWTTFFKQSCFCGGVWAD
Length1133
PositionTail
OrganismAscoidea rubescens DSM 1968
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Ascoideaceae> Ascoidea.
Aromaticity0.11
Grand average of hydropathy-0.326
Instability index39.84
Isoelectric point9.15
Molecular weight129525.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09544
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     542.12|      72|      90|      69|     140|       1
---------------------------------------------------------------------------
    7-   57 (67.04/22.25)	..........DN..................PDI......Y.S......L....LNQNYQNKI.S...WSNNG......V.....IAYSNP.DSSNKY.NL.LLSY.LR..SYN....G....................................NQW
   69-  140 (130.06/50.09)	NSNL.....NNN..................SNI......K.N......I....IKNNTKNNI.K...TNNNNNNI...I.....ISNAIPIDTQNNS.SLDQISYLLW..SNN....G.......TYLA..CVD...SK..............GNMN
  157-  230 (72.66/24.74)	NSNT.....SNN...........................K.N............KTNTPLNF.AffgSCFNSLEI...I.....YQDT..VLTQ.GS.TPPENSYLNT..SHNiypsN.......TSIP..TFDnycST..............YNIN
  258-  336 (62.06/20.06)	NFSE.....NMN..................ANA......EyD......F....QKFGFKYNY.I...NSTYKNPVthpV.....LKKHACIGLRKNG.EL.....ILWyqGDH....GldynkisTYLD..S.S...SA..............TTTN
  338-  405 (54.07/16.52)	..SI.....NNI..................NNI......S.N......I.......NYKS.I.N...SLNNSGHT...I.....ISHADFAFQINNS.IL...........................LTvyCPL...IKilkiysirilweflGNPN
  411-  472 (58.66/18.55)	QSAY.....QQD..................NNLderfppK.L......I....VKKILSENI.S.....................SFGFDGSSQWLS.SIKSISPVYF..EDN...................TN...SN..............EKVD
  479-  532 (44.59/12.34)	NSNL.....NEKfntlickyhlekkklgpiSNV......F.Y......Q....ISNNLKN.........NTNKNI...........N....DTGNNN.........................................................NMN
  577-  669 (52.98/16.04)	NSFLyfaysNGN..................IEI......R.NkhslkiIgyktLLENPANNVnK...RNVINNDI...LnmpstIGNIFDVGYKLPSvGFNPLFYSFS..PNV....T.......SYVV..LSS...KD..............PNL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.93|      19|     180|     547|     574|       3
---------------------------------------------------------------------------
  547-  574 (22.96/32.22)	TNSNISgyelslKSLIkssSPVL.........SIGTN
  736-  763 (26.98/13.60)	TDSNIC......KALI...SIILlecywifnfSLTTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.58|      14|      15|     858|     872|       6
---------------------------------------------------------------------------
  858-  872 (20.79/21.40)	DYVTFLNqQLLQFSL
  875-  888 (23.79/17.83)	DKATALS.ELLIFPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09544 with Med16 domain of Kingdom Fungi
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