<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09541

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLDDNNIVNKNKVIKQKLNENKSSELIDKNLKTKNKIQKVIDSSDKHSLNSYDELSKSINDKFNCINNKLENFFSSPNDEFNEKNNEEFNEKFKSLINIFDYFDSKTETEHKYNEVQSGTIQENSENFLIKEEFYVKNRKDPVNEIMNGSHSNEHYINNLNMNSDHDHESEVESYGLESDEEMESENDHKDIEKKIFNIDQSEKGEKTYCQHSFSSKFEESLRKLFPFVKVINLLELVDVDLSNIDGIKFRRLKGSGIINDYSFSSQLISKNEKLFEDHIFKIKQAQIKTRKLNQEIKLNFNAINFWKVLGLKPLHGPKNFKILFLVDGSNESFFETARKFLSDIIENYKNCGLGNIEKVNCSKLILNLKYQVTRKNMAGKNEVFNADNIEERRSSAGISKEEQSVNDLGFLDDGIFNVGCFNDNFDIYYQTIQKKMSVLAKALDLNERQKLKKFENLLVEQSEGVNHSILDNRPILVLFATKFNDMVSILQISKLFYEFQQLLKIPNKDFENLNSIKRSQNQEINSNNSIIESFLKVIPVEFFNSSKLPPSHETFNKFSLNLYNSCPNTSKDYVCMAKTLPEKIEFQFSSSPSADLILSEGLYLHLAYQRSIDKNWCVACWTDQWGNMKNLKSWYCPSFIINRESFNNQQFENSVGRKNSFEEVSNEMWATSIKMMSSFNGKTYLILTRTNSMIPDDELYQWKRLSISNNKIPLIVLSVKSNSKFVLDLPESSFPFDNIFKECNNLMRHGLNTNCQREEHESELVDIDKIKFNQKNQYNIVNIREEVYGIILKNSIPLFNEVSRLPLKTGFLAKPLKDSDKKLMIFEVNLLSCPSNLISTNLLKTLLIQLRNLSLYSSIAGVYNDGGKSIVPWHIIAVEKVINTLIHIRVKQPTLKEK
Length899
PositionKinase
OrganismAscoidea rubescens DSM 1968
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Ascoideaceae> Ascoidea.
Aromaticity0.10
Grand average of hydropathy-0.552
Instability index43.26
Isoelectric point6.44
Molecular weight104387.34
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09541
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.92|      15|      15|      54|      68|       1
---------------------------------------------------------------------------
   54-   68 (27.17/10.07)	ELSKSINDKFNCINN
   72-   86 (27.75/10.42)	NFFSSPNDEFNEKNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.83|      41|      56|     354|     394|       2
---------------------------------------------------------------------------
  300-  339 (46.16/28.40)	......NFNAINFWK.VLGLKPLHGPKNfkilflVDGSNESF.....FETAR
  354-  394 (71.35/48.46)	LG....NIEKVNCSKLILNLKYQVTRKN......MAGKNEVF.NADNIEERR
  409-  450 (50.33/31.72)	LGflddGIFNVGCFNDNFDIYYQTIQKK......MS....VLaKALDLNERQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.86|      37|      41|     505|     543|       3
---------------------------------------------------------------------------
  505-  543 (53.00/33.77)	KIPnKDFENLNSIKRS.QNQEINSNNSIIeSFLKVIP..VEF
  548-  587 (58.85/29.71)	KLP.PSHETFNKFSLNlYNSCPNTSKDYV.CMAKTLPekIEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.56|      15|      15|     649|     663|       4
---------------------------------------------------------------------------
  649-  663 (25.93/16.51)	NQQFENSVGRKNSFE
  667-  681 (27.63/18.11)	NEMWATSIKMMSSFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.64|      14|      16|       2|      17|       5
---------------------------------------------------------------------------
    2-   17 (20.20/15.12)	LDDN........NIVNKNKVikQK
   18-   39 (17.44/ 6.46)	LNENksselidkNLKTKNKI..QK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.77|      29|      60|      90|     134|       7
---------------------------------------------------------------------------
   90-  126 (41.05/45.37)	NEKFKSLINIfdyfdsktETEHKY.NEVQSGTIQENSE
  153-  182 (46.72/18.92)	NEHYINNLNM........NSDHDHeSEVESYGLESDEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     257.44|      76|     606|     184|     291|       8
---------------------------------------------------------------------------
  214-  291 (122.44/123.49)	FSSK.FEESLRKLFPFvkVINLL....ELVDVDLSNIDGIKFRRLKG......SGIIND..YSFSSQLISKNE.KLFED.....HIFKIKQAQIKTR
  764-  810 (49.57/17.69)	................................ELVDIDKIKFNQKNQ......YNIVNI..REEVYGIILKNSiPLFNE......VSRL...PLKT.
  812-  899 (85.44/40.74)	FLAKpLKDSDKKLMIF..EVNLLscpsNLISTNLLKTLLIQLRNL..slyssiAGVYNDggKSIVPWHIIAVE.KV...intliHI.RVKQPTLKEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09541 with Med13 domain of Kingdom Fungi
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