<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09541

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLDDNNIVNKNKVIKQKLNENKSSELIDKNLKTKNKIQKVIDSSDKHSLNSYDELSKSINDKFNCINNKLENFFSSPNDEFNEKNNEEFNEKFKSLINIFDYFDSKTETEHKYNEVQSGTIQENSENFLIKEEFYVKNRKDPVNEIMNGSHSNEHYINNLNMNSDHDHESEVESYGLESDEEMESENDHKDIEKKIFNIDQSEKGEKTYCQHSFSSKFEESLRKLFPFVKVINLLELVDVDLSNIDGIKFRRLKGSGIINDYSFSSQLISKNEKLFEDHIFKIKQAQIKTRKLNQEIKLNFNAINFWKVLGLKPLHGPKNFKILFLVDGSNESFFETARKFLSDIIENYKNCGLGNIEKVNCSKLILNLKYQVTRKNMAGKNEVFNADNIEERRSSAGISKEEQSVNDLGFLDDGIFNVGCFNDNFDIYYQTIQKKMSVLAKALDLNERQKLKKFENLLVEQSEGVNHSILDNRPILVLFATKFNDMVSILQISKLFYEFQQLLKIPNKDFENLNSIKRSQNQEINSNNSIIESFLKVIPVEFFNSSKLPPSHETFNKFSLNLYNSCPNTSKDYVCMAKTLPEKIEFQFSSSPSADLILSEGLYLHLAYQRSIDKNWCVACWTDQWGNMKNLKSWYCPSFIINRESFNNQQFENSVGRKNSFEEVSNEMWATSIKMMSSFNGKTYLILTRTNSMIPDDELYQWKRLSISNNKIPLIVLSVKSNSKFVLDLPESSFPFDNIFKECNNLMRHGLNTNCQREEHESELVDIDKIKFNQKNQYNIVNIREEVYGIILKNSIPLFNEVSRLPLKTGFLAKPLKDSDKKLMIFEVNLLSCPSNLISTNLLKTLLIQLRNLSLYSSIAGVYNDGGKSIVPWHIIAVEKVINTLIHIRVKQPTLKEK
Length899
PositionKinase
OrganismAscoidea rubescens DSM 1968
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Ascoideaceae> Ascoidea.
Aromaticity0.10
Grand average of hydropathy-0.552
Instability index43.26
Isoelectric point6.44
Molecular weight104387.34
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09541
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.92|      15|      15|      54|      68|       1
---------------------------------------------------------------------------
   54-   68 (27.17/10.07)	ELSKSINDKFNCINN
   72-   86 (27.75/10.42)	NFFSSPNDEFNEKNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.83|      41|      56|     354|     394|       2
---------------------------------------------------------------------------
  300-  339 (46.16/28.40)	......NFNAINFWK.VLGLKPLHGPKNfkilflVDGSNESF.....FETAR
  354-  394 (71.35/48.46)	LG....NIEKVNCSKLILNLKYQVTRKN......MAGKNEVF.NADNIEERR
  409-  450 (50.33/31.72)	LGflddGIFNVGCFNDNFDIYYQTIQKK......MS....VLaKALDLNERQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.86|      37|      41|     505|     543|       3
---------------------------------------------------------------------------
  505-  543 (53.00/33.77)	KIPnKDFENLNSIKRS.QNQEINSNNSIIeSFLKVIP..VEF
  548-  587 (58.85/29.71)	KLP.PSHETFNKFSLNlYNSCPNTSKDYV.CMAKTLPekIEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.56|      15|      15|     649|     663|       4
---------------------------------------------------------------------------
  649-  663 (25.93/16.51)	NQQFENSVGRKNSFE
  667-  681 (27.63/18.11)	NEMWATSIKMMSSFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.64|      14|      16|       2|      17|       5
---------------------------------------------------------------------------
    2-   17 (20.20/15.12)	LDDN........NIVNKNKVikQK
   18-   39 (17.44/ 6.46)	LNENksselidkNLKTKNKI..QK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.77|      29|      60|      90|     134|       7
---------------------------------------------------------------------------
   90-  126 (41.05/45.37)	NEKFKSLINIfdyfdsktETEHKY.NEVQSGTIQENSE
  153-  182 (46.72/18.92)	NEHYINNLNM........NSDHDHeSEVESYGLESDEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     257.44|      76|     606|     184|     291|       8
---------------------------------------------------------------------------
  214-  291 (122.44/123.49)	FSSK.FEESLRKLFPFvkVINLL....ELVDVDLSNIDGIKFRRLKG......SGIIND..YSFSSQLISKNE.KLFED.....HIFKIKQAQIKTR
  764-  810 (49.57/17.69)	................................ELVDIDKIKFNQKNQ......YNIVNI..REEVYGIILKNSiPLFNE......VSRL...PLKT.
  812-  899 (85.44/40.74)	FLAKpLKDSDKKLMIF..EVNLLscpsNLISTNLLKTLLIQLRNL..slyssiAGVYNDggKSIVPWHIIAVE.KV...intliHI.RVKQPTLKEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09541 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DHESEVESYGLESDEEMESENDHKDIEKKIF
167
197










Molecular Recognition Features






MoRF SequenceStartStop




NANANA