<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09530

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMQSTPAIPTPTSISAPTPNPCQPDTYDEVRALMKEFTEIRGIQSAFNAFIVHDDNYAEEVFNTLQSKLAKVLSEGTSPESVERAIKHIISITGQPTNNDETVEILMKILEKLVASSNVSARLVCEALLESERLTIRNSKFWINSFVLIKKIIPGVDYKGVREIMKISLDKAALFPEKILPSQLPQLNAVVRLLQYIFDRNACLLPAYFIVNEILKNYPEKRQFPHWKLSQLLSDFVDSFQPIAQMVTVIGRSRMLPVVEHSHSGYSLLSWKLDPVTLRFVVKGNLPYDKDLLQPQDRLLRFILEQPYSRDMVCAILGLQKQLKIRCSTLEDRLVELVIVAMEKTEAEMNQANDPQSGYDEISAATLWLWQHLSTQLIFFVLFQLASFPHIVMSIHNKLSEIKLFKGRDFLMWVLLQFISGSIQKNSLGDFLPVLRLYDLLYPEKDALVVPDITKPYCVSQMAATCIWIHILKKAQTENQFLCRPLPTALKKQYEYLQSIAVQNSTQPSLNVCDFRVALLANAFSTNSELFSRPMGALVEAMHGSTSSSVSSQISVAPLSVQILDSLTVHTKMSLIHNIVTHIMKISTTKSGQNLNPALVETYARLLVYLEIESLGIKGFMSQLLPNVFKSQAWGILHTLLEMFCYRLHHIQPHYRVQLLSHLNALANNAHSNSAQLHMCVETTALRLITSFNSVDVHTQFSRVGGDCKSLVSSESEELNRALVLTLARAIHVTGSDTIAGSGGSNWYRDILTAIMQNTPHSWSTHVLQAFPPVVYDFFQQNQVPKENKQQLKNMVDEEYRNWNAMISNEKELIEHFASQGTPPLFLCILWKMVLETDRVNPVAPKVIERIGPKGISANLRKFCDYVVCEFANAGAGQYVNKLADAISDLIWKFNIIPFDRLLLCLALRSHEGNEAQVCFFIIHMLLIKPLEFKNRIQEFVRDNSPEHWKQTSWHEKHKSFNAKYPEVSYFEGQQQNPIPMYFGNVCLRFLPVFDIMIHRFLEMNNIQKSLELMLEQMSPLYKFHDRPVTYLYNTLHYYESRLRDKPSLKKKLISAILGALRDIKPTNWALSDQYQTFLQGSNEDINWAPDIDYYAGLINRFVDVIEGRRKFFAPVDWRFNEFPNPPAHVLHATCVEIMALPVTPTVAANGILEVMMCSRAEMDANEANMDVESWFNSTGLILVTLPESYWLLLHERIVSTIEKLSTWSHKYTPLQLFNFKTVKNGFLYSEYANLLAITHAVWYHLGIGHMHHIQTLITDKLSSIVQNEIQLLFIGHLVAPFLQRLNTERPNMVCRLTVAFYELLEKVDKSISKDACLTYMDVFCDLLYHIKYMYTGDVVKTDVEPIIGRLRPALQLRFRFITHLNIEDISVAAPSQGTTQVPATNQNLQNMLGMQGMKYSHD
Length1402
PositionTail
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.10
Grand average of hydropathy-0.042
Instability index44.35
Isoelectric point6.79
Molecular weight160208.73
Publications
PubMed=27289101

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09530
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     400.15|     153|     238|      49|     217|       1
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   19-  189 (225.70/185.74)	NPCQPDTYDEVRALMKEF.....teirgiqsafnaFIVHDDNYAEEVFNTLQSKLAKVLSEGTSPESV......ERAIKHIISitGQ.PTNNDeTVEILMKILeKLVASSNVSARLVCEALLESERLTIRNS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................kfWINSFVLIKKIIPGVDYKGVREIMKISLDKAALFPEKILPSQLPQLNAV
  200-  327 (133.83/83.25)	NACLLPAYFIVNEILKNYpekrqfphwklsqllsdFVDSFQPIAQMVTVIGRSRMLPVVEHSHSGYSLlswkldPVTLRFVVK..GNlPYDKD.LLQPQDRLL.RFILEQPYSRDMVCAILGLQKQLKIRCS...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1174- 1222 (40.61/13.07)	....................................................................................................................................tledrlvelvivamekteaemnqandpqsgydeisaatlwlwqhlstqliffvlfqlasfphivmsihnklseiklfkgrdflmwvllqfisgsiqknslgdflpvlrlydllypekdalvvpditkpycvsqmaatciwihilkkaqtenqflcrplptalkkqyeylqsiavqnstqpslnvcdfrvallanafstnselfsrpmgalveamhgstsssvssqisvaplsvqildsltvhtkmslihnivthimkisttksgqnlnpalvetyarllvyleieslgikgfmsqllpnvfksqawgilhtllemfcyrlhhiqphyrvqllshlnalannahsnsaqlhmcvettalrlitsfnsvdvhtqfsrvggdckslvsseseelnralvltlaraihvtgsdtiagsggsnwyrdiltaimqntphswsthvlqafppvvydffqqnqvpkenkqqlknmvdeeyrnwnamisnekeliehfasqgtpplflcilwkmvletdrvnpvapkvierigpkgisanlrkfcdyvvcefanagagqyvnkladaisdliwkfniipfdrlllclalrshegneaqvcffiihmllikplefknriqefvrdnspehwkqtswhekhksfnakypevsyfegqqqnpipmyfgnvclrflpvfdimihrflemnniqkslelmleqmsplykfhdrpvtylyntlhyyesrlrdkpslkkklisailgalrdikptnwalsdqyqtflqgsnedinwapdidyyaglinrfvdviegrrkffapvdwrfnefpnppahvlhatcveimalpvtptvaangilevmmcsraemdaneanmdvesWFNSTGLILVTLPESYWLLLHERIVSTIEKLSTWSHKYTPLQLFNFKTV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.18|      16|     261|     860|     875|       2
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  860-  875 (32.06/20.21)	RKF...CDYVVCEFANAGA
 1109- 1127 (29.12/17.66)	RKFfapVDWRFNEFPNPPA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.91|      67|     194|     695|     784|       5
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  707-  784 (103.47/109.79)	CKSLvssESEELNRALVLTLarAIHVTgsdTIAGSGGSNWYRDIltaIMQNTPHSW...STH....VLQA.FPPVVY.DFFQQNQVP
  904-  979 (107.44/61.70)	CLAL...RSHEGNEAQVCFF..IIHML...LIKPLEFKNRIQEF...VRDNSPEHWkqtSWHekhkSFNAkYPEVSYfEGQQQNPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.18|      13|     190|     221|     233|       9
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  221-  233 (25.39/13.64)	RQFPHWKLSQLLS
  407-  419 (22.79/11.50)	RDFLMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.87|      21|     190|     625|     653|      10
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  625-  647 (35.15/34.77)	PNVFKSQAWgiLHTLLEMFCYRL
  667-  687 (36.72/15.21)	NNAHSNSAQ..LHMCVETTALRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     228.32|      81|     862|     394|     495|      15
---------------------------------------------------------------------------
  394-  495 (120.86/100.40)	IHNKLS.....EIK.LFKGrdflmwvllqfisGSIQKnsLGDFLP..VLRL....YDLLypEKdalVVPDITKPYCVSQMAATC.IWIHIlKKAQTEN..QFLCRP....LPTALKKQYEY
 1257- 1360 (107.46/67.05)	ITDKLSsivqnEIQlLFIG.........hlvaPFLQR..LNTERPnmVCRLtvafYELL..EK...VDKSISKDACLTYMDVFCdLLYHI.KYMYTGDvvKTDVEPiigrLRPALQLRFRF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09530 with Med23 domain of Kingdom Metazoa
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