<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09528

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNNPVPDFAFLTLFLGVMRGQQGHAKVTWRQAVALASRPFLMRLERSPNARQTASLSVSDPSASATKPEQTHPHTKPSDFQCVWRHRGERAAPGRTQQEQLTTWPPQFNHRPANDVAQFTSDQLIPTPAFTRRENELGPAAPSDTRRQRVQPHSHQAAGQGFPASLSPMTSHSQQSSLFNSTNANNSSSNANGPSLSGPKELWIFWYGEEPELSSLVHSNLLKSESEQGSWENVCMSVDVRQHPSVKRVSKQQLVVCQAPSQTVPVILAPYGLAGTLTGVGYRMSDPGTHKILEEWKQFYPVEAALKAPTYDVSTSTSTHGPHSSPHSATNGANNQQQQQQASPGVNQGAPALSSAGIPPVLEVIVGGVRMRYPSCYVLCTELDELPRSLETNSSNTSSNAPVALKTKTSPNKGVKDSETATCPAVKSPGRPQGTLTISRKVDKVEGLLPERVWQETILPSQPLAKIPSSNDQSSTLSSSEQANSANTTNICDTAGQWDFVDPTKKLGCACSKCKRPSGSKGMMSGSQSTKSGTKVKKSTFHKRSVQQLTQIEGWATHWSLTEETINSATNTNQQMVNGPIKTENQGINQQSANRVNAPPGTPVGGPPSYKTAPLGMAGEGPGASPASVAPSPLATPRSQPASVSQPEPTMPTLSPQPCSSEKPPVQTPDNGGPKSVSSLSNQVYSPAVTSFDGAKAEPTDQGNAAGGNAGNNDAPILESSAHVNNASSVTLVSGIPSGRENGLKFLKRPVLPSKEYETLLVEENANQPSETLYDYTSMEAWLNHPVKRMKASEGNSLTSMYSWGWGLRKNSDSIHGSGSEERSHSRKRKADPYEFDDENHQIPLVNLDGFKRNGIKEEEKSPFCQGESGSKGVAGNLFTNEGLQPSFRDLDQIFDNSDTSSDETFQVPTPPGSNKPANLLEDANLPSLTCTGGTKSKSGLNILRPEELSKMFPTPPSQPEHNPIASPCGLQTDNPSLEGLSDPSICIRRTQDGYPVLGSPPDDTMEVRIESNLFLKSGTQQSLRMHYQDWSYVFKPATVYKMLGSSKYSPLSTLPSQKEPPLPLSGSILLYKASWQSPPQSSTAPPATTSAPTQVQIPHPPNPVTPNIPNPLHLRPGLSPISPVPTSIRGTPFDLGSPPSNNMYLKQGPHGPNTHNSMPNHPGHHIYGSRGPEAHALVVNLSLSDSVIGLFRDHNFDSCTMCVCNANNKIIGNIRGSEMGIYVQDTSPEEEAVRCNCGFSASANRRLAHRSGLFYEDEYEITTSSLAPLALPSDEWYERKKQSLLLLDPKYTNAVALSSDRDLTAASNIVDTIPPYLLEMLKEQCILLFGSSTASRFTGEVINNGWSDWQINYLENLDANRAALIALEHGRSIMIEASGRSGYSRLPEDMIPIKNSVNLLHKWQFLWVRGPKSSQDIMNVMKALHPLLQDAVHAKAWDAQYTVSGPLTWRQFHRLAGRGTDDRCEPQPIPSILVGSEKDWLSLSPLAIRFWEKLLLEPYAYPRDVAYIVVCPDSDVIIHRVKTFFREFSSMYEVCQLGKHCPVTKVLQDGIVRVGKTAATRLASEPLDEWFSMLPDIPVASILKLYAKVCKHFLAHKLSTISLDQSLFDASYHNQNSQSRVYSQDRPTPSPKMPPPGTEPGMMPQGPPTPKTEYEAEPPKECQAQENPDDDERDPPALVVYFIEPCGFRSDNDDLHRMVSLGLLRCFASMVNGLPELIKNNITLQVLSLEDILNLGNTTLETRLKNDQMRAMALTVYSQCRRLLVHQNNVKSLTGFGPAAAAELFIKSKDEKKKGSYRLYTPPYILAPTKEKVSEGVEWLNGLQGHTVGGMVSSGLALNAGNPPLPTASSVLYVAYCLSEDQRWLLASATDERGELLETTTISIYVPNRSKRRKASARKHGLQKLMDFILGVMSTGVQPWRLVVGRLGRIGHGELESWSTLLSRKSLLRASNQLKIACHQCSLQYPADTPCVLSACLVSLEPDSCLRLMPDLFTPDERFSASGTTGSLSTPQDVSCTHILVFPTSATTQSSQTAFQEQHINGPDLGDEDLLFINVQEDMSDGIDGMQDLQLGDIFSWADTGPGAPSPVGSPRRDSASQPGSPGGIGASGRQSPFQSGGQGRTGGRGDSGEELGTLLQQPLALGYFVSTAPSGKLPNWFWSSCPQRSIENGAAVFLKSALHLHSHNILHNIDDPLQQQSNAKQHPLDSQFTTDVLRFVLEGYNALSWLCLDPVTHDRKSCLPVHIQKLLQLYYTITTLV
Length2259
PositionMiddle
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.06
Grand average of hydropathy-0.488
Instability index56.28
Isoelectric point6.45
Molecular weight246177.95
Publications
PubMed=27289101

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09528
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.11|      14|      15|    2083|    2096|       1
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  139-  152 (24.17/ 9.44)	PAAPSDTRRQRVQP
 2083- 2096 (28.48/12.69)	PGAPSPVGSPRRDS
 2100- 2113 (23.46/ 8.90)	PGSPGGIGASGRQS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.53|      15|      15|     633|     647|       2
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  633-  647 (27.94/12.89)	P.LATPRSQPASVSQP
  649-  664 (26.58/11.84)	PtMPTLSPQPCSSEKP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     181.53|      37|     237|     323|     360|       3
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  323-  360 (61.65/33.53)	HSSPHSATNG...A.....NNQQQQQQA..SPGVNQgAPALSSA.GIPP
  578-  608 (42.77/18.02)	........NGpikT.....ENQGINQQS..ANRVN..APPGTPV.GGPP
  666-  694 (34.60/13.05)	VQTP...............DNGGPKSVSslSNQVY..SPAVTSF.DG..
  696-  737 (42.50/17.86)	KAEPTDQGNA...AggnagNNDAPILES..SAHVNN.ASSVTLVsGIP.
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     361.30|     155|     866|     943|    1181|       4
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  943- 1016 (68.34/168.78)	IlRPEELSkMFpTPPSQPEHNPIASPCGLQTD.NPSL...EGL.SDPSICIrRTQDGYPvLGSPPDDTMEVRIESNLFL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1092- 1181 (122.51/ 6.99)	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ksgtqqslrmhyqdwsyvfkpatvykmlgsskysplstlpsqkepplplsgsillykaswqsppqsstappattsAPTQVQIPHPPNpvTPNI.........PNP.LHLRPGLspISPVPT.SIRGTPFDLGSPPS.NNMYLKQGPHGPNTHNSMPNHPGHHIYGSRGPEAHALVVN
 1215- 1288 (67.68/20.59)	I.RGSEMG.IY.VQDTSPEEEAVRCNCGFSASaNRRLahrSGLfYEDEYEI.TTSSLAP.LALPSDEWYERKKQSLLLL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1958- 2055 (102.76/ 0.00)	...............................................................................dpkytnavalssdrdltaasnivdtippyllemlkeqcillfgsstasrftgevinngwsdwqinylenldanraalialehgrsimieasgrsgysrlpedmipiknsvnllhkwqflwvrgpkssqdimnvmkalhpllqdavhakawdaqytvsgpltwrqfhrlagrgtddrcepqpipsilvgsekdwlslsplairfweklllepyayprdvayivvcpdsdviihrvktffrefssmyevcqlgkhcpvtkvlqdgivrvgktaatrlasepldewfsmlpdipvasilklyakvckhflahklstisldqslfdasyhnqnsqsrvysqdrptpspkmpppgtepgmmpqgpptpkteyeaeppkecqaqenpddderdppalvvyfiepcgfrsdnddlhrmvslgllrcfasmvnglpeliknnitlqvlsledilnlgnttletrlkndqmramaltvysqcrrllvhqnnvksltgfgpaaaaelfikskdekkkgsyrlytppyilaptkekvsegvewlnglqghtvggmvssglalnagnpplptassvlyvayclsedqrwllasatdergelletttisiyvpnrskrrkasarkhglqklmdfilgvmstgvqpwrlvvgrlgrighgeleswstllsrksllrasnqlkiACHQCSLQYPAD..TPCVlsaclvslePDScLRLMPDL..FTPDERfSASGTTGSLSTPQDvSCTHILVFPTSATTQSSQTAFQEQHINGPDLGDEDLLFIN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.58|      36|     591|    1025|    1086|       5
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 1025- 1080 (39.34/49.11)	RMHYQDwsyvfKPaTVykmlgSSKYSPLST....LPsqKEPPLPLSGsillYKAswqSPP
 1621- 1660 (69.24/26.25)	RVYSQD.....RP.TP.....SPKMPPPGTepgmMP..QGPPTPKTE....YEA...EPP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.67|      51|     591|    1565|    1616|       6
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 1565- 1616 (84.78/57.44)	SEPLDEWF.SMLPDIPVASILKLYAKVCKHFLAHKLsTISLDQSLFDASYHNQ
 2152- 2203 (85.88/53.88)	SGKLPNWFwSSCPQRSIENGAAVFLKSALHLHSHNI.LHNIDDPLQQQSNAKQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.18|      52|     591|     270|     322|       7
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  270-  322 (88.68/58.74)	PYGLAGTLTgVGYRMSDPGTHKILEE..WKQ.FYPVEAALKAPTYDVSTSTSTHGP
  368-  402 (52.06/27.85)	...........GVRMRYPSCYVLCTE..LDE.L.P..RSLETN....SSNTSSNAP
  429-  476 (60.45/34.08)	PGRPQGTLT.ISRKVDK..VEGLLPErvWQEtILPSQPLAKIPSSNDQSST.....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.40|      11|     485|    1315|    1325|       8
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 1315- 1325 (21.63/10.84)	PPYLLEMLKEQ
 1803- 1813 (21.77/10.96)	PPYILAPTKEK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.64|      30|     350|     479|     549|      11
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  514-  549 (40.22/83.86)	CKRPSGSKGmMSGSQSTKSGTkvkKSTFhkRSVQQL
  865-  894 (55.41/17.26)	CQGESGSKG.VAGNLFTNEGL...QPSF..RDLDQI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09528 with Med13 domain of Kingdom Metazoa
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