<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09526

Description Mediator of RNA polymerase II transcription subunit 12-like protein (Fragment)
SequenceMMIYSWEKRPLKRPRLGPPDVYPQDPKQREDELTAVNVKQGFSHTPQLSDEFGSAKNANISANKLGAFINGVNSKKSENASLPDTGKKRLQVNTKDHFWHVTPRMKSTLEVWMNDLAGGKQLAAIAKKVPIFNKREEIFLTLSEHQVPMVRATWFLKMTASYNSAMSEAKTKKRQIPDPSQEWTLALQRCCKDIFMRLTEWYNGGSGAGLITSINAVIPVGPGGLPVPGANLGPGLTPTMHQNPPSVPGSTTLNQPPGAPNTSTMNGTASNVPGQNSNPQSISPTANCEDGSGILKQWSYCIELAKFLYEEGLLDRYEWLVWIIDVCDKTKSIDDHAWKTLTPLLLSYLPDIAQSELLSRRIATSAAKKLSAMFTDQDFTLLSPLGGCPPSPPVGVTERLQCPTHRSTVFGLSSVIQVISLECPTSLVYNANLTALNNEGGRNSVPGGSALDILPIQPSILPMPPRSNNHIIRAQLREAENHIIARSRAVEAKWSCDEWQQSSAGTTLQKVLSVLDALDRHSFDKVEAGSSLETLYSKIFPNPPNKDNPVEADAPVVILLCQWAVCSQRTGEHRALAVARLLEQRQTETTTTNDGEPPILEGQIGLFENAEGSKNGSEGTPGEDTPMNGNESEGGNCDTNVGSNGSNNGGNGADSEDSEFGYSLPIYHNLLFKFLDADAPVLDETSVRSKTTFSSLVNLFGALIRHDVFSHDAYLCALVARGDLSTVPQSLSSASSMPPTSVQPINSVATPGPASQAGPNTPASVSSVTPGTTPHHDLVDERGPLFPPLPRLPETHRQTDYDDRNIDDDLDLILQRITQEQQNSMDQVDSPKDDTVVGGVTGFGSVTPNTHQQNATTPMVTDSSMSAIKSGVVGSNSTNSSTTFNSELTKQSRHRLFVTHFPLPQDDNFQHEINQRHILLYGCGRARDEARHMVKKVSKELGKLFSKKFCYDVSDGSRVKKQSKNEINFEQLQTRFAALPYFDQHAVTSTAGQTALEMLAAFATGRGNYLPTVEHIAYLTELMEASLHITGLIELSISMLRELPDIESQLSSRISPIASTYTTSVQLQLVAVLRRYHCSLLQFHLFWIYVFTCKVDTESTSAGWENLTRLMRRLSSNVECTSAERCTLAYLTELQACCGLLRSKNLTDYLTPTAAKLRQSLCSPVQPAESSHEWNNAFMTQCLDNPRRKVDNSIVRQLLENPGCRYSFVCNAILSICNEADAERLNDLASLCADMTAACPPLASEWLGVLQTLCSPSRHVVSYADILREVDIKHLSIHSSLATLTALLVARQCFSLQDFVMQAVPSLLKAWNEGRGPNDPDTEAGARLTCHLLLSLFKTQDCVTTVGNPSVLRLSCDRRLLSATHSSVTLGAVLAALKAMLLLADAASTGTGERRRDQRTLPGISAGELSISHILGTSDVPSERNSASDAIRGEPRTLASFAFSALHQMCGELWVRQRCLQNPDDLCNQEMLLDPIVSAKQAQRLLYMICYPELPVPEENLDARTHIPRILEGLNQWNIREAWLALTLQNKQLNSSPVEYQTWLDIVARAALEVFHLGHEDGQEFAIPNSAAPSPAPGKSPRSGKKTQQQSQEQIAKTPPSSFNVPNSQSIASAAGIGIAVNGIDGNKDNTNLDVDGMNANALGDYGSYGWVANAQWLIAPLVAKLSSFVQGRVLRHAGKSDLPPILYSETVSKCFFLQIIMIGNVLENTLWPKNYGKSKNSSGPLPPLNGVGSSSLHAHLPFLALVLTCLRGQDEQREGLLASLLNQFTQLLNYAKEREFDLRSDVLRDAIRLRLSLVGGMFDAVQRSSTATAEWAVVLTQLVTHGVVDINNNRDIIMEINFAFLLRFSDVFPTIVDMITALVHSTQIAEPGDRVEEMKRQNMNLVKKLKKELADRDSTSIKPLRQLLPFSKVQTDVLVTQATSMIIDSKGNRVPSFEFVDKKPGLQVWEKQRVSPWEIIECQRNPAPLSWAWFGAVKMERKNLRYEETHRLLKFHTHSLVKNSSHFLEPVPLPPEEIDPAPFPGPPMSNQMPSGPTQPPPNYPPGPPPPQWYNGQQPQQPFYTAQQVSSGGRPPNNQQSKQAIQHFLRARHTATAPPAPGASNQFQQFPQGPPTGPSGPPGPRHQNILRQQLRGQTPPAVPIQNQGFQGQPVMQPNQGVMFQQQSVPGQGNYMYGSEIYGYSQSSMGSQGQPVSAVLGHRSGGPVSGMMPPQQQQMNTMMGQRPPGFMQGNPQSGPTNSMNPMQAGYRRPQMGQMVQPGQLGGPGQIGPQSTGQMGQPVHGQMVQSMQNPGQMVQGGMGGPGMNNMVQQGQMGQPGMQNPGMRQFAMQQQQNHPQQQQGMGMGPRMHFQNQQAHVTGLFHALL
Length2365
PositionKinase
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.06
Grand average of hydropathy-0.386
Instability index49.25
Isoelectric point6.58
Molecular weight259113.65
Publications
PubMed=27289101

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09526
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.31|      18|      20|    2244|    2262|       1
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 2038- 2061 (25.64/ 7.22)	T.QpppnypPGPPPPQWYNGQQPQQ
 2111- 2124 (28.42/ 8.89)	P.Q.......G..PP.TGPSGPPGP
 2244- 2262 (32.25/15.16)	PmQ......AGYRRPQMGQMVQPGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     153.22|      19|      20|    2293|    2311|       2
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  224-  242 (27.91/10.63)	GLPVPGANL.GPGLTPTMHQ
 2160- 2177 (24.99/ 8.55)	GVMFQ.QQS.VPGQGNYMYG
 2293- 2311 (40.97/19.90)	GQMVQGGMG.GPGMNNMVQQ
 2312- 2330 (31.83/13.41)	GQMGQPGMQ.NPGMRQFAMQ
 2336- 2354 (27.51/10.34)	PQQ.QQGMGmGPRMHFQNQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.72|      18|      21|    2188|    2205|       3
---------------------------------------------------------------------------
 2069- 2080 (22.74/ 7.48)	VS......SGG.....RPPNNQQ
 2195- 2217 (28.86/11.85)	VSAVLGHRSGGpvsgmMPPQQQQ
 2218- 2234 (26.11/ 9.89)	MNTMMGQRPPG....fM..QGNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.22|      19|      20|     734|     753|       4
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  734-  753 (33.05/22.61)	ASSMPPTSVQPINSVaTPG..P
  754-  774 (31.16/16.23)	ASQAGPNTPASVSSV.TPGttP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      15|      20|     619|     638|       5
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  619-  633 (28.64/21.68)	GTPGEDTPMNGNESE
  642-  656 (25.95/ 6.64)	GSNGSNNGGNGADSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.62|      17|      23|    1327|    1347|       6
---------------------------------------------------------------------------
 1327- 1344 (27.52/26.35)	RLTCHLLLsLFKTQDCVT
 1353- 1369 (30.10/14.00)	RLSCDRRL.LSATHSSVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.94|      11|      84|    2182|    2194|       9
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 2264- 2274 (22.01/ 8.80)	GGPGQI..G.PQ.ST
 2275- 2289 ( 9.94/ 8.78)	GQMGQPvhGqMVqSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.99|      11|      17|    1514|    1524|      11
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 1514- 1524 (21.97/14.50)	LNQWNIR.EAWL
 1533- 1544 (16.02/ 8.16)	LNSSPVEyQTWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.31|      16|      19|    1217|    1232|      12
---------------------------------------------------------------------------
 1217- 1232 (28.67/16.26)	CNEADAERLNDLASLC
 1239- 1254 (31.63/18.72)	CPPLASEWLGVLQTLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.93|       9|      19|     400|     410|      13
---------------------------------------------------------------------------
  400-  410 (14.23/14.95)	LQCPThrSTVF
  421-  429 (18.71/10.18)	LECPT..SLVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.34|      19|      23|     248|     270|      14
---------------------------------------------------------------------------
  248-  267 (31.55/22.78)	PGSTTlNQPPGAPNTSTMNG
  273-  291 (35.79/14.05)	PGQNS.NPQSISPTANCEDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.65|      18|      23|    1933|    1950|      15
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 1933- 1950 (33.55/22.17)	NRVPSFEFVD..KKPGLQVW
 1953- 1972 (30.09/18.96)	QRVSPWEIIEcqRNPAPLSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.12|      37|     531|    1563|    1627|      16
---------------------------------------------------------------------------
 1572- 1627 (51.05/67.41)	APsPAPGKSP...................RSGKKTQQQSQEQiakTPPssfnvpnsqsiasaaGIGIAVNGIDGN
 2097- 2152 (61.07/25.32)	AP.PAPGASNqfqqfpqgpptgpsgppgpRHQNILRQQLRGQ...TPP...............AVPIQNQGFQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.89|      12|      16|     446|     457|      17
---------------------------------------------------------------------------
  446-  457 (21.31/ 9.77)	PGGSALDILPIQ
  464-  475 (22.59/10.80)	PPRSNNHIIRAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.39|      17|      21|     497|     513|      20
---------------------------------------------------------------------------
  497-  513 (29.70/18.65)	DEWQQSS.....AGTTLQKVLS
  516-  537 (22.69/12.22)	DALDRHSfdkveAGSSLETLYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.31|      16|      20|    1744|    1761|      24
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 1744- 1759 (27.63/20.67)	LALVL...TCLRGQDEQRE
 1762- 1780 (20.68/ 6.49)	LASLLnqfTQLLNYAKERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.74|       8|      21|    1466|    1476|      25
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 1466- 1476 (11.18/14.17)	LCNQEMlldPI
 1489- 1496 (16.57/ 8.89)	ICYPEL...PV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.05|      30|     280|    1382|    1447|      26
---------------------------------------------------------------------------
   60-   89 (51.25/17.17)	ISANKLG.AFINGVNSKKSENASLPDT..GKKR
 1404- 1436 (42.80/39.75)	ISAGELSiSHILGTSDVPSERNSASDAirGEPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.52|      19|      23|     789|     808|      28
---------------------------------------------------------------------------
  789-  808 (31.25/23.97)	LPRLPEtHRQTDYD..DRNIDD
  814-  834 (29.26/17.02)	LQRITQ.EQQNSMDqvDSPKDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.13|      17|     111|    1875|    1904|      29
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  368-  384 (29.89/10.70)	KKLSAMFTDQDFTLLSP
 1888- 1904 (28.24/ 9.13)	KKLKKELADRDSTSIKP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09526 with Med12 domain of Kingdom Metazoa
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