<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09523

Description Mediator of RNA polymerase II transcription subunit 28
SequenceMNAEITNGTGSNGFVHSNPVDKLEGAFMSCLAAITKEDTLTNVDKDEIRVDVEQGLLNFVDQARSMEGYFLKKRLEIAAQKPELIIKDDASELRFEMVRKDELLKKNYEKINVWQSILADLQSAGAQQSKNIPTGSVASVGVSLPSQGPATPGAQGPLTPSSGRPNTPGSVGRPITPVISTTGSRMHTAIRSQLIQKNPAAAVGFARILPPPSPHFSSSSMEQPRPNQDRSSLQSLLACPAPDIRIRLSEMLTRPVPETSVILNPLHTMEQQQRRNMPYLSRPACSHSHSHNMLPFQTQGETGASGTRSCHISSVMRPPSPSIMPPPPTAHFQYFYDQAGVMMTRTNVPMQLNAHANPHQYPNNCFRFRRNQSEFPNKLPSCTKDMTSRKK
Length391
PositionHead
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.05
Grand average of hydropathy-0.547
Instability index64.11
Isoelectric point9.40
Molecular weight43030.49
Publications
PubMed=27289101

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09523
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.04|      62|     106|     149|     226|       1
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  149-  216 (100.29/83.61)	PATPGAQGPL..TPSSGRPNTPgSVGRP.........ITPvISTTGSRMHTAIRS...QLIQKNPAAAVgfarILPPPSPHF
  257-  332 (99.75/49.75)	PETSVILNPLhtMEQQQRRNMP.YLSRPacshshshnMLP.FQTQGETGASGTRSchiSSVMRPPSPSI....MPPPPTAHF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09523 with Med28 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVGFARILPPPSPHFSSSSMEQPRPNQDRSSLQSLLAC
2) QSKNIPTGSVASVGVSLPSQGPATPGAQGPLTPSSGRPNTPGSVGRPITPVISTTGSRMHTAIRSQL
3) RLSEMLTRPVPETSVILNPLHTMEQQQRRNMPYLSRPA
4) SHSHNMLPFQTQGETGASGTRSCHISSVMRPPSPSIM
201
128
247
288
239
194
284
324










Molecular Recognition Features






MoRF SequenceStartStop




1) HFQYFYD
331
337