<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09521

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMPVLDKLTIPLSNPSPNDVVFVVEGTALCGAYLNELKTAYILPTLEYFNGGALDEKDCGSDSNFAVYGLVIFHAADVLPGYLTEAYGPITTPHKLITTLDKYQFTGGYGEAASHIGEGLATAMQCLQDMTGFRNPMPELPVKKHVILICNCKPYGLPVTESVGSDGAYRGMTAEQLASQMMERGVHLSIMSPRKIPALISLFDRGGGESSTQKTYARDVRHLVLLNGFHLQERPITPKQVPDVPTIMHPPPQISQPPAPSNPPPPMPTAPSMQPQVPISMAQSQPSQQTTAPPQTIQVQPSQTPVMSTASSVPSSMQQTSMQSGTVSMAQNTTQNTMNPIMINQTQASLGMNPPHSPNPLIVLRNRAPSPMQMQTIRQMQMQNQQINSNQPMNPGMNHPGQPISQASMNPGQQQIGPGQMNPQLINSQAMLPNQTQMNMNQQQQQQQLNQQLQNQQQPINQPMNPQMTQQFQNQQQMNQPMTPQQMNQQQLTSTLLGPKLMASQLSQQHLGNMQQPQQNQQQQPTGQPAMRWQTQMPSASPMQKLPQQVPLVRMTNVNQPQPPSSTQPLQPQINASQPILSTGINQPSALSSKISSNNNNQRSSNNNTQQQQQQTTTTEQQTAATTTTQQAQQPQQPPHSTLLAQLKIPPIAQTPQQAAQPAQGGLLTGQAPMNSQKERQTIWSGTLEWHEKQKGPPDGQKIPRQVPCQVSAYVVNGEAEVKGEGWPQKLIMQLIPKNIVGSLGGSFLVRDVKTVVFLLKNCDALNSLTRVMDSGYAGCVHFTGTGMPQNACTIKVLILLYSKDRQTYLGFIPNDQVGFVDRIRKVIQQQKQQQQSTRQGQVFPSSGGMSQQPGMMPSQQSGMVQGQQPGMVQGQQSGMVQAQQGGMVQPQQTGMMQTSQSGMVQQQGMVQSQQSTISSLAQQLGQSQSGMSQSPVTALAQQLGQAQQLQQQIQQQVQNPNLQQGNIDSGQSQAELAQLEMERQQNLLTIQQLQQTLQAAQQKELQFQQLQHHPTVGPGSGHQAGPGSGQIQVQVGPGGQQILQPGQQQQQQQQQQQQQQQLQQVSRPMMTPQAIGQMRMLRTSVSQANPGLKHLLQQQPGPQNYRMQMPMQQQRMPGGMPMQGQMPPNQQVQQVNQFEEVGILDLLK
Length1148
PositionUnknown
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.03
Grand average of hydropathy-0.678
Instability index60.42
Isoelectric point9.14
Molecular weight125881.39
Publications
PubMed=27289101

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09521
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     745.56|      97|      97|     936|    1032|       6
---------------------------------------------------------------------------
  281-  400 (91.01/14.23)	..AQS.....QPS...QQTTA..............PPQTIQvQPSQTPvmstassvpsSMQQT...................SMQSG..TVSMAQN...........TTQN...T...........................MNPIMINQT..........................QASLgmnpphspnplivlrnrapspmqmQTIRQ.................MQMQN.QQINSNQPMNPGMNH.....PG.....
  401-  497 (99.11/16.34)	..........QPI...SQASM............npGQQQIG.PGQMNP..........QL.......................INSQAMLPNQTQM...........NMNQ...Q...........................QQQ...QQL..........................NQ..............................QlqnqqqpinqpmnpqmtQQFQN.QQQMNQP.MTPQQMNQQQ..LTSTLLG
  498-  595 (84.78/12.61)	PKLMAsqlsqQHL...GNMQQ..............PQQNQQ.QQ...P.....................................TGQP..................AMRW...QtqmpsaspmqklpqqvplvrmtnvnqpQPPSSTQPL..........................QPQI........................NAS............................Q..PILSTGI.NQPS..ALSSKIS
  624-  711 (101.57/16.98)	ATTTT.....QQA...QQPQQpphstllaqlkippIAQTPQ.QAAQ.P............AQG...................GLLTGQA..................PMNS...Q...........................KE.................................RQTI........................WSG....................TLEW.HEKQKGPPDGQKIPRQV...P..CQVS
  715-  858 (72.97/ 9.53)	VNGEA.....EVK...GEGWP...............QKLIM.QLI.PK..........NI.VGslggsflvrdvktvvfllkNCDALNSLTRVMDSgyagcvhftgtGM.....P...........................QNACTIKVLillyskdrqtylgfipndqvgfvdriRKVI........................QQQKQ.................QQQST.RQGQVFPSSG.GMSQQPGmmPS.....
  936- 1032 (163.76/33.17)	VTALA.....QQL...GQAQQ..............LQQQIQ.QQVQNP..........NLQQG...................NIDSGQSQAELAQL...........EMER...Q...........................QNLLTIQQL..........................QQTL........................QAAQQ.................KELQF.QQLQHHPTVGPGSGHQAG..PGSGQIQ
 1035- 1133 (132.36/25.00)	VGPGG.....QQIlqpGQQQQ..............QQQQQQ.QQQQQ............LQQV...................SRPMMTPQA.IGQM...........RMLRtsvS...........................QANPGLKHL..........................LQQQ........................PGPQN.................YRMQMpMQQQRMPGGMPMQGQM....PPNQQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     184.34|      42|      42|     153|     194|       7
---------------------------------------------------------------------------
   59-   94 (23.51/ 8.48)	.........GSDSnfAVYGLvifhAADV....LPGYLTE..A..YGPITTPHK..
  108-  153 (55.34/29.99)	YGEAASH.IG.EG..LATAM....QCLQdmtgFRNPMPELPVkkHVILICNCK.P
  154-  196 (66.01/37.19)	YGLPVTESVGSDG..AYRGM....TAEQ....LASQMMERGV..HLSIMSPRKiP
  197-  230 (39.48/19.27)	ALISLFDRGGGES..STQKT....YARD....VRHLVLLNGF..HL.........
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09521 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KELQFQQLQHHPTVGPGSGHQAGPGSGQIQVQVGPGGQQILQPGQQQQQQQQQQQQQQQLQQVSRPMMTPQAIGQMRMLRTSVSQANPGLKHLLQQQPGPQNYRMQMPMQQQRMPGGMPMQGQMPPNQQVQQVNQ
2) QQSTRQGQVFPSSGGMSQQPGMMPSQQSGMVQGQQPGMVQGQQSGMVQAQQGGMVQPQQTGMMQTSQSGMVQQQGMVQ
3) RPITPKQVPDVPTIMHPPPQISQPPAPSNPPPPMPTAPSMQPQVPISMAQSQPSQQTTAPPQTIQVQPSQTPVMSTASSVPSSMQQTSMQSGTVSMAQNTTQNTMNPIMINQTQASLGMNPPHSPNPLIVLRNRAPSPMQMQTIRQMQMQNQQINSNQPMNPGMNHPGQPISQASMNPGQQQIGPGQMNPQLINSQAMLPNQTQMNMNQQQQQQQLNQQLQNQQQPINQPMNPQMTQQFQNQQQMNQPMTPQQMNQQQLTSTLLGPKLMASQLSQQHLGNMQQPQQNQQQQPTGQPAMRWQTQMPSASPMQKLPQQVPLVRMTNVNQPQPPSSTQPLQPQINASQPILSTGINQPSALSSKISSNNNNQRSSNNNTQQQQQQTTTTEQQTAATTTTQQAQQPQQPPHSTLLAQLKIPPIAQTPQQAAQPAQGGLLTGQAPMNSQKERQTIWSGTLEWHEKQKGPPDGQKIP
1003
834
233
1137
911
703










Molecular Recognition Features






MoRF SequenceStartStop




NANANA